Results 101 to 110 of about 505,018 (335)
The application and outlook of proteomics in Ovarian Cancer, Breast Cancer, and Colon Cancer [PDF]
BIO Web of ConferencesCancer, a pervasive challenge of global health, necessitates advanced technologies for diagnosticsand therapies. Ovarian, breast, and colon cancers, notable for their complexity, have made significantdiscoveries with the help of proteomics.
Xie Yiru
doaj +1 more source
Molecular Oncology, EarlyView.The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song +11 more
wiley +1 more source
Neuropeptide reporter assay for serum, capillary blood and blood cards
MethodsX, 2020 In the associated main paper (JPBA 2019), substance P was shown to be a valuable neuropeptide reporter substance to monitor the protease activity of serum. The assay was developed based on the predecessor assay using bradykinin (JPBA 2017).
U. Schreiber +3 more
doaj
Intricacies in arrangement of SNP haplotypes suggest “Great Admixture” that created modern humans
BMC Genomics, 2017 Background Inferring history from genomic sequences is challenging and problematic because chromosomes are mosaics of thousands of small Identicalby-descent (IBD) fragments, each of them having their own unique story.
Rajib Dutta +8 more
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau +9 more
wiley +1 more source
Learning important features from multi-view data to predict drug side effects
Journal of Cheminformatics, 2019 The problem of drug side effects is one of the most crucial issues in pharmacological development. As there are many limitations in current experimental and clinical methods for detecting side effects, a lot of computational algorithms have been ...
Xujun Liang +6 more
doaj +1 more source
Revisiting biomarker discovery by plasma proteomics
Molecular Systems Biology, 2017 Clinical analysis of blood is the most widespread diagnostic procedure in medicine, and blood biomarkers are used to categorize patients and to support treatment decisions.
Philipp E. Geyer +3 more
semanticscholar +1 more source
Journal of Investigative Dermatology, 2014 The power of proteomics in cultured skin fibroblasts from individuals with either systemic sclerosis or recessive dystrophic epidermolysis bullosa has led to the common finding of senescence and deficiencies in autophagy. Both of these disorders exert high demand on fibroblast activity, and without the protective action of autophagy cellular stress ...
openaire +2 more sources
EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines
Molecular Oncology, EarlyView.The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche +8 more
wiley +1 more source
Proteomics: Technologies and Their Applications.
Journal of Chromatographic Science, 2017 Proteomics involves the applications of technologies for the identification and quantification of overall proteins present content of a cell, tissue or an organism.
B. Aslam +4 more
semanticscholar +1 more source