Results 121 to 130 of about 784,733 (395)

Asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA) and homoarginine (hArg): the ADMA, SDMA and hArg paradoxes

Cardiovascular Diabetology, 2018
NG-Methylation of l-arginine (Arg) residues in certain proteins by protein arginine methyltransferases and subsequent proteolysis yields NG-monomethyl-l-arginine (MMA), NG,NG-dimethyl-l-arginine (asymmetric dimethylarginine, ADMA) and NG,N′G-dimethyl-l ...
Dimitrios Tsikas, Alexander Bollenbach, Erik Hanff, Arslan Arinc Kayacelebi   +3 more
doaj   +1 more source

Analysis of the Human Tissue-specific Expression by Genome-wide Integration of Transcriptomics and Antibody-based Proteomics*

Molecular & Cellular Proteomics, 2013
Global classification of the human proteins with regards to spatial expression patterns across organs and tissues is important for studies of human biology and disease.
Linn Fagerberg, B. Hallström, P. Oksvold, C. Kampf, Dijana Djureinovic, J. Odeberg, Masato Habuka, Simin Tahmasebpoor, A. Danielsson, K. Edlund, A. Asplund, E. Sjöstedt, E. Lundberg, C. Szigyarto, Marie Skogs, Jenny Ottosson Takanen, H. Berling, Hanna Tegel, J. Mulder, P. Nilsson, J. Schwenk, C. Lindskog, Frida Danielsson, A. Mardinoğlu, Åsa Sivertsson, K. von Feilitzen, Mattias Forsberg, M. Zwahlen, Ingmarie Olsson, S. Navani, M. Huss, J. Nielsen, F. Pontén, M. Uhlén   +33 more
semanticscholar   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Multiplexed proteomic biosensor platform for label-free real-time simultaneous kinetic screening of thousands of protein interactions

Communications Biology
Studying protein interactions in high throughput (HTP) is critical for advancing many aspects of drug discovery, biomarker identification, and diagnostic development.
Chidozie Victor Agu, Rebecca L. Cook, William Martelly, Lydia R. Gushgari, Mukilan Mohan, Bharath Takulapalli   +5 more
doaj   +1 more source

The Green Proteome: Challenges in Plant Proteomics [PDF]

Frontiers in Plant Science, 2011
An organism is an expression of its underlying molecular composition that reacts and responds to a variety of stimuli. Central to this response are proteins, which undertake a multitude of functional and structural roles throughout an organism.
openaire   +4 more sources

A proteomic glimpse into human ureter proteome [PDF]

PROTEOMICS, 2015
Urine has evolved as one of the most important biofluids in clinical proteomics due to its noninvasive sampling and its stability. Yet, it is used in clinical diagnostics of several disorders by detecting changes in its components including urinary protein/polypeptide profile.
Sameh Magdeldin, Sameh Magdeldin, Sameh Magdeldin, John R. Yates, Amr Elguoshy, Amr Elguoshy, Bo Xu, Ying Zhang, Hidehiko Fujinaka, Yoshitoshi Hirao, Tadashi Yamamoto, Keiko Yamamoto   +11 more
openaire   +3 more sources

Mining whole sample mass spectrometry proteomics data for biomarkers: an overview

, 2009
In this paper we aim to provide a concise overview of designing and conducting an MS proteomics experiment in such a way as to allow statistical analysis that may lead to the discovery of novel biomarkers.
Bennell, J., McDonald, R, O'Connor, David, Potts, Chris N., Skipp, Paul, Thomas, Lyn C.   +5 more
core   +1 more source

Protein processing characterized by a gel-free proteomics approach [PDF]

, 2008
We describe a method for the specific isolation of representative N-terminal peptides of proteins and their proteolytic fragments. Their isolation is based on a gel-free, peptidecentric proteomics approach using the principle of diagonal chromatography ...
A. Staes, C. C. Wu, D. N. Perkins, J. Ji, J. Krijgsveld, K. Gevaert, K. Gevaert, K. Gevaert, K. Kuhn, L. Martens, L. McDonald, M. Mann, M. Miyagi, P. Damme Van, P. Meuleman, R. J. Beynon, S. E. Ong, Z. Szeltner   +17 more
core   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Perseus: A Bioinformatics Platform for Integrative Analysis of Proteomics Data in Cancer Research.

Methods in molecular biology, 2018
Mass spectrometry-based proteomics is a continuously growing field marked by technological and methodological improvements. Cancer proteomics is aimed at pursuing goals such as accurate diagnosis, patient stratification, and biomarker discovery, relying ...
Stefka Tyanova, Jüergen Cox
semanticscholar   +1 more source