Results 311 to 320 of about 62,588 (334)

The diverse functions of small heat shock proteins in the proteostasis network.

Journal of Molecular Biology, 2021
The protein quality control (PQC) system maintains protein homeostasis by counteracting the accumulation of misfolded protein conformers. Substrate degradation and refolding activities executed by ATP-dependent proteases and chaperones constitute major ...
Kevin Reinle, A. Mogk, B. Bukau
semanticscholar   +1 more source

Proteostasis and Disease

2020
Proteostasis regulates key cellular processes such as cell proliferation, differentiation, transcription, and apoptosis. The mechanisms by which proteostasis is regulated are crucial and the deterioration of cellular proteostasis has been significantly associated with tumorigenesis since it specifically targets key oncoproteins and tumor suppressors ...
Erbaykent Tepedelen, Burcu, Erzurumlu, Yalçın, Gözen, Oğuz, Ballar Kırmızıbayrak, Petek   +3 more
openaire   +3 more sources

Proteostasis and Neurodegeneration

2020
Proteostasis or protein homeostasis consists of a complex interrelated cellular system that controls several steps of protein quality and function from the initial step of synthesis as well as folding, and eventually degradation over enormous biochemical pathways. Proteostasis involves controlling protein folding, modification of the post-translational
Md. Ataur Rahman, Md Saidur Rahman, Md Jamal Uddin, A. N. M. Mamun-Or-Rashid, Md. Rezanur Rahman, Myung-Geol Pang, Hyewhon Rhim   +6 more
openaire   +1 more source

Altered Proteostasis in Neurodegenerative Tauopathies

2020
Tauopathies are a heterogeneous group of neurodegenerative dementias involving perturbations in the levels, phosphorylation or mutations of the neuronal microtubule-binding protein Tau. Tauopathies are characterized by accumulation of hyperphosphorylated Tau leading to formation of a range of aggregates including macromolecular ensembles such as Paired
Katerina, Papanikolopoulou, Efthimios M C, Skoulakis   +1 more
openaire   +2 more sources

Proteostasis in neurodegenerative diseases

Proteostasis is essential for normal function of proteins and vital for cellular health and survival. Proteostasis encompasses all stages in the "life" of a protein, that is, from translation to functional performance and, ultimately, to degradation. Proteins need native conformations for function and in the presence of multiple types of stress, their ...
Sumit, Kinger, Yuvraj Anandrao, Jagtap, Prashant, Kumar, Akash, Choudhary, Amit, Prasad, Vijay Kumar, Prajapati, Amit, Kumar, Gunjan, Mehta, Amit, Mishra   +8 more
openaire   +3 more sources

Molecular chaperones in protein folding and proteostasis

Nature, 2011
F. Hartl, A. Bracher, M. Hayer-Hartl
semanticscholar   +1 more source

Dysregulated proteostasis

2023
Yasmeen Al-Mufti, Stephen Cranwell, Rahul S. Samant   +2 more
openaire   +1 more source

RESETting proteostasis

Nature Chemical Biology, 2014
Julia Noack, Maurizio Molinari
openaire   +3 more sources

p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors.

Cancer Cell
A. Carugo, R. Minelli, Luigi Sapio, M. Soeung, F. Carbone, Frederick S. Robinson, James Tepper, Ziheng Chen, S. Lovisa, M. Svelto, S. Amin, Sanjana Srinivasan, Edoardo Del Poggetto, S. Loponte, F. Puca, Prasenjit Dey, G. Malouf, X. Su, Liren Li, D. Lopez-Terrada, D. Rakheja, A. Lazar, G. Netto, P. Rao, A. Sgambato, A. Maitra, D. Tripathi, C. Walker, J. Karam, T. Heffernan, A. Viale, C. Roberts, P. Msaouel, N. Tannir, G. Draetta, G. Genovese   +35 more
semanticscholar   +1 more source

Proteostasis and Its Role in Disease Development

Cell Biochemistry and Biophysics
M. Shukla, Mahesh Narayan
semanticscholar   +1 more source