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Elucidation of host-virus surfaceome interactions using spatial proteotyping
2021The cellular surfaceome and its residing extracellularly exposed proteins are involved in a multitude of molecular signaling processes across the viral infection cycle. Successful viral propagation, including viral entry, immune evasion, virion release and viral spread rely on dynamic molecular interactions with the surfaceome.
Fabian, Wendt +2 more
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Proteotyping for the rapid identification of influenza virus and other biopathogens
Chemical Society Reviews, 2013The influenza virus is one of the most deadly infectious agents known to man and has been responsible for the deaths of some hundred million lives throughout human history. The need to rapidly and reliably survey circulating virus strains down to the molecular level is ever present.
Kevin M Downard
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Systematic and Applied Microbiology, 2015
Modern microbial systematics requires a range of methodologies for the comprehensive characterization, classification and identification of microorganisms. While whole-genome sequences provide the ultimate reference for defining microbial phylogeny and taxonomy, selected biomarker-based strategies continue to provide the means for the bulk of microbial
Roger Karlsson +2 more
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Modern microbial systematics requires a range of methodologies for the comprehensive characterization, classification and identification of microorganisms. While whole-genome sequences provide the ultimate reference for defining microbial phylogeny and taxonomy, selected biomarker-based strategies continue to provide the means for the bulk of microbial
Roger Karlsson +2 more
exaly +4 more sources
Proteotyping Gene Dosage Effects in Genetic Diseases
The FASEB Journal, 2017Introduction and Objectives Gene dosage imbalance is a general working hypothesis for studying the genetic diseases, such as human syndromes, because the DNA copy number variations (CNVs) are causal for many genetic diseases.
Yansheng Liu, Ruedi Aebersold
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Toward milk speciation through the monitoring of casein proteotypic peptides
Rapid Communications in Mass Spectrometry, 2010Abstract The possibility of detecting extraneous milk in singles species cheese‐milk has been explored. A mass spectrometry (MS)‐based procedure has been developed to detect 'signature peptides', corresponding to the predefined subset of 'proteotypic peptides', as matchless analytical surrogates of the parent ...
Cuollo M +5 more
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The use of proteotypic peptide libraries for protein identification
Rapid Communications in Mass Spectrometry, 2005Abstract This paper describes an algorithm to apply proteotypic peptide sequence libraries to protein identifications performed using tandem mass spectrometry (MS/MS). Proteotypic peptides are those peptides in a protein sequence that are most likely to be confidently observed by current MS‐based proteomics ...
Robertson, Craig +2 more
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Proteotyping For Drug Development: Proteomics Impacting Clinical Practice
The FASEB Journal, 2016The road to medical translation starts with understanding of an individual's history and disease status via the quantification of proteins and their disease‐induced modified forms. Each individual's proteome reflects both their cellular memory and current health status and should allow prediction of their response to environment and therapeutic ...
Jennifer Van Eyk +4 more
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Absolute two-point quantification of proteins using dimethylated proteotypic peptides
The Analyst, 2018For absolute quantification of target proteins by LC-MS, adding two versions of spike-in peptides can be used as a quality control against each other.
The Trung Tran +3 more
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Microorganism proteotyping by tandem mass spectrometry
2020La biosphère microbienne constitue une source importante de catalyseurs biologiques, dont l’identification et la caractérisation restent à ce jour limitées. La phylopeptidomique est une approche de métaprotéomique innovante pour l’identification taxonomique sans a priori des micro-organismes procaryotes et eucaryotes.
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