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LineageFilter: Improved Proteotyping of Complex Samples Using Metaproteomics and Machine Learning
Journal of Proteome ResearchInternational audienceMetaproteomics is a powerful tool to characterize how microbiota function by analyzing their proteic content by tandem mass spectrometry.
Lucia Grenga +2 more
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Alpha-1-Antitrypsin (A1AT) Proteotyping by LC-MS/MS
2023The diagnosis of alpha-1-antitrypsin (A1AT) deficiency is established by quantitation of protein concentration in serum (immunoassay) followed by determination of specific allelic variants by phenotyping (isoelectric focusing (IEF) gel electrophoresis) and/or allele-specific genotyping.
Jennifer, Kemp +2 more
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GroEL-proteotyping of bacterial communities by tandem mass spectrometry
2023Abstract Profiling bacterial populations in mixed communities is a common task in microbiology. 16 S rRNA-based sequencing is a widely accepted and functional approach but relies on amplification primers and cannot quantify isotope incorporation.
Simon Klaes +4 more
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Proteotyping for the rapid identification of influenza virus and other biopathogens
Chemical Society Reviews, 2013The influenza virus is one of the most deadly infectious agents known to man and has been responsible for the deaths of some hundred million lives throughout human history. The need to rapidly and reliably survey circulating virus strains down to the molecular level is ever present.
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Proteotyping Gene Dosage Effects in Genetic Diseases
The FASEB Journal, 2017Introduction and Objectives Gene dosage imbalance is a general working hypothesis for studying the genetic diseases, such as human syndromes, because the DNA copy number variations (CNVs) are causal for many genetic diseases.
Yansheng Liu, Ruedi Aebersold
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Apolipoprotein E Proteotyping as a Valid Alternative to Genotyping in Clinical Practice.
Journal of Alzheimer's DiseaseThe apolipoprotein E ε4 allele ( APOE ε4) is associated with higher incidence of amyloid-related imaging abnormalities in patients with Alzheimer's disease undergoing anti-amyloid therapy, underscoring the importance of allele status testing.
Jordi A Matías-Guiu +2 more
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Microorganism proteotyping by tandem mass spectrometry
2020La biosphère microbienne constitue une source importante de catalyseurs biologiques, dont l’identification et la caractérisation restent à ce jour limitées. La phylopeptidomique est une approche de métaprotéomique innovante pour l’identification taxonomique sans a priori des micro-organismes procaryotes et eucaryotes.
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Proteotyping of Campylobacter jejuni by MALDI-TOF MS and Strain Solution Version 2 Software
Microorganisms, 2023Teruyo Ojima-Kato, Hiroto Tamura
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