Results 121 to 130 of about 507 (153)

Unexpected Low Rate of Amyloid-β Pathology in Multiple Sclerosis Patients. [PDF]

Ann Neurol
Brier MR, Schindler SE, Salter A, Perantie D, Shelley N, Judge B, Keefe S, Kirmess KM, Verghese PB, Yarasheski KE, Venkatesh V, Raji CA, Gordon BA, Bateman RJ, Morris JC, Naismith RT, Holtzman DM, Benzinger TLS, Cross AH.   +18 more
europepmc   +1 more source

Single-cell landscape of innate and acquired drug resistance in acute myeloid leukemia. [PDF]

Nat Commun
Wegmann R, Bonilla X, Casanova R, Chevrier S, Coelho R, Esposito C, Ficek-Pascual J, Goetze S, Gut G, Jacob F, Jacobs A, Kuipers J, Lischetti U, Mena J, Milani ES, Prummer M, Del Castillo JS, Singer F, Sivapatham S, Toussaint NC, Vilinovszki O, Wildschut MHE, Thavayogarajah T, Malani D, TumorProfiler Consortium, Aebersold R, Bacac M, Beerenwinkel N, Beisel C, Bodenmiller B, Heinzelmann-Schwarz V, Koelzer VH, Levesque MP, Moch H, Pelkmans L, Rätsch G, Tolnay M, Wicki A, Wollscheid B, Manz MG, Snijder B, Theocharides APA.   +41 more
europepmc   +1 more source

Proteotyping: Proteomic characterization, classification and identification of microorganisms – A prospectus

Systematic and Applied Microbiology, 2015
Modern microbial systematics requires a range of methodologies for the comprehensive characterization, classification and identification of microorganisms. While whole-genome sequences provide the ultimate reference for defining microbial phylogeny and taxonomy, selected biomarker-based strategies continue to provide the means for the bulk of microbial
Roger Karlsson, Fredrik Boulund, Liselott Svensson-Stadler   +2 more
exaly   +5 more sources

High-throughput proteotyping of bacterial isolates by double barrel chromatography-tandem mass spectrometry based on microplate paramagnetic beads and phylopeptidomics

Journal of Proteomics, 2020
Corresponding author : Jean Armengaud (jean.armengaud@cea.fr)International audienceTandem mass spectrometry-based proteotyping of microorganisms presents several advantages over whole-cell MALDI-TOF mass spectrometry: because a larger number of signals ...
Karim Hayoun, Jean-Charles Gaillard, Olivier Pible   +2 more
exaly   +2 more sources

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Proteotyping pluripotency with mass spectrometry

Expert Review of Proteomics, 2019
Pluripotency emerges transiently during embryogenesis in two main forms with different developmental potential, termed naïve and primed states. Importantly, these pluripotent states can be recapitulated in vitro under specific culture conditions, representing a unique model to study the regulatory principles of development and cellular plasticity ...
Cristina, Sayago, Ana, Martinez-Val, Javier, Munoz   +2 more
openaire   +2 more sources

Variant mapping using mass spectrometry–based proteotyping as a diagnostic tool in von Willebrand disease [PDF]

Journal of Thrombosis and Haemostasis
Background: von Willebrand disease (VWD) is the most common inherited bleeding disorder, characterized by either partial or complete von Willebrand factor (VWF) deficiency or by the occurrence of VWF proteoforms of altered functionality.
Carmen Van Der Zwaan
exaly   +4 more sources

Computational prediction of proteotypic peptides

Expert Review of Proteomics, 2007
Evaluation of: Mallick P, Schirle M, Chen SS et al. Computational prediction of proteotypic peptides for quantitative proteomics. Nat. Biotechnol. 25(1), 125–131 (2007).Mass spectrometry, the driving analytical force behind proteomics, is primarily used to identify and quantify as many proteins in a complex biological mixture as possible.
Josip, Blonder, Timothy D, Veenstra
openaire   +2 more sources

Scoring proteomes with proteotypic peptide probes

Nature Reviews Molecular Cell Biology, 2005
Technologies for genome-wide analyses typically undergo a transition from a discovery phase to a scoring phase. In the discovery phase, the genomic universe is explored and all pertinent data are noted. In the scoring phase, relevant entities are screened to reveal groups of genes that are associated with specific biological processes or conditions. In
Bernhard, Kuster, Markus, Schirle, Parag, Mallick, Ruedi, Aebersold   +3 more
openaire   +2 more sources

Proteotypic Peptides and Their Applications

2016
Recent advances in mass spectrometry based proteomic techniques and publicly available large proteomic repositories are being exploited to characterize the proteome of multiple organisms. While humongous amount of proteomic data is being acquired and analyzed, many biological questions still remain unanswered.
Shivakumar, Keerthikumar, Suresh, Mathivanan   +1 more
openaire   +2 more sources