Results 111 to 120 of about 333 (136)
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Proteotype Co-evolution and Diversity in Mammals
2022Abstract Evolutionary profiling has been largely limited to the nucleotide level. Using consistent proteomic methods, we quantified proteomic and phosphoproteomic layers in fibroblasts from 11 common mammalian species, with transcriptomic variability as reference.
Qian Ba +8 more
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The use of proteotypic peptide libraries for protein identification
Rapid Communications in Mass Spectrometry, 2005Abstract This paper describes an algorithm to apply proteotypic peptide sequence libraries to protein identifications performed using tandem mass spectrometry (MS/MS). Proteotypic peptides are those peptides in a protein sequence that are most likely to be confidently observed by current MS‐based proteomics ...
Robertson, Craig +2 more
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Computational prediction of proteotypic peptides for quantitative proteomics
Nature Biotechnology, 2006Mass spectrometry-based quantitative proteomics has become an important component of biological and clinical research. Although such analyses typically assume that a protein's peptide fragments are observed with equal likelihood, only a few so-called 'proteotypic' peptides are repeatedly and consistently identified for any given protein present in a ...
Parag, Mallick +11 more
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Alpha-1-Antitrypsin (A1AT) Proteotyping by LC-MS/MS
2023The diagnosis of alpha-1-antitrypsin (A1AT) deficiency is established by quantitation of protein concentration in serum (immunoassay) followed by determination of specific allelic variants by phenotyping (isoelectric focusing (IEF) gel electrophoresis) and/or allele-specific genotyping.
Jennifer, Kemp +2 more
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Proteotyping of the Parainfluenza Virus with High-Resolution Mass Spectrometry
Analytical Chemistry, 2013Parainfluenza viruses (PIVs) are one of the most common causes of respiratory tract infections in children and can be life-threatening when the airway becomes obstructed. Infection results in a spectrum of respiratory disease symptoms that makes diagnosis difficult.
An P, Nguyen, Kevin M, Downard
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GroEL-proteotyping of bacterial communities by tandem mass spectrometry
2023Abstract Profiling bacterial populations in mixed communities is a common task in microbiology. 16 S rRNA-based sequencing is a widely accepted and functional approach but relies on amplification primers and cannot quantify isotope incorporation.
Simon Klaes +4 more
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Elucidation of host-virus surfaceome interactions using spatial proteotyping
2021The cellular surfaceome and its residing extracellularly exposed proteins are involved in a multitude of molecular signaling processes across the viral infection cycle. Successful viral propagation, including viral entry, immune evasion, virion release and viral spread rely on dynamic molecular interactions with the surfaceome.
Fabian, Wendt +2 more
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Proteotyping for the rapid identification of influenza virus and other biopathogens
Chemical Society Reviews, 2013The influenza virus is one of the most deadly infectious agents known to man and has been responsible for the deaths of some hundred million lives throughout human history. The need to rapidly and reliably survey circulating virus strains down to the molecular level is ever present.
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Proteotyping Gene Dosage Effects in Genetic Diseases
The FASEB Journal, 2017Introduction and Objectives Gene dosage imbalance is a general working hypothesis for studying the genetic diseases, such as human syndromes, because the DNA copy number variations (CNVs) are causal for many genetic diseases.
Yansheng Liu, Ruedi Aebersold
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Microorganism proteotyping by tandem mass spectrometry
2020La biosphère microbienne constitue une source importante de catalyseurs biologiques, dont l’identification et la caractérisation restent à ce jour limitées. La phylopeptidomique est une approche de métaprotéomique innovante pour l’identification taxonomique sans a priori des micro-organismes procaryotes et eucaryotes.
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