Results 211 to 220 of about 145,714 (241)
Some of the next articles are maybe not open access.
Prothrombin madrid : A new familial abnormality of prothrombin
Thrombosis Research, 1979Abstract An abnormal prothrombin has been detected in a 13 yr-old girl, with history of excessive bleeding. Prothrombin time and activated partial thromboplastin time were markedly prolonged. Prothrombin activity was very low when measured by biological assay using either physiological activators (3% by one stage assay and 20 US u/ml by two stage ...
A. Bezeaud +4 more
openaire +3 more sources
Journal of the American Medical Association, 1947
To the Editor:— The recent current comment on Stability of Prothrombin inThe Journal, September 9, page 36, contains Certain statements to which I am compelled to take exception; particularly to one: "Unreliable values for prothrombin obtained by the one stage method etc." It might be well to inquire concerning the actual facts.
openaire +3 more sources
To the Editor:— The recent current comment on Stability of Prothrombin inThe Journal, September 9, page 36, contains Certain statements to which I am compelled to take exception; particularly to one: "Unreliable values for prothrombin obtained by the one stage method etc." It might be well to inquire concerning the actual facts.
openaire +3 more sources
Lupus, 2012
Research on antiphospholipid antibodies (aPL) and the thrombotic manifestations associated with these antibodies has grown since the description of anticardiolipin antibodies (aCL) by Harris and colleagues in the early 1980s. Antiprothrombin (aPT) antibodies are commonly detected by ELISA, using irradiated plates (aPT) or prothrombin in complex with ...
openaire +4 more sources
Research on antiphospholipid antibodies (aPL) and the thrombotic manifestations associated with these antibodies has grown since the description of anticardiolipin antibodies (aCL) by Harris and colleagues in the early 1980s. Antiprothrombin (aPT) antibodies are commonly detected by ELISA, using irradiated plates (aPT) or prothrombin in complex with ...
openaire +4 more sources
American Journal of Physiology-Legacy Content, 1956
In the activation of a prothrombin solution, only part of the prothrombin becomes biothrombin, some becomes autoprothrombin I and some becomes autoprothrombin II. Thrombin-thrombin is also obtained, and perhaps other derivatives of prothrombin are formed. Prothrombin thus has multiple potentialities and these can be developed in diverse ways.
J A, PENNER, W H, SEEGERS
openaire +2 more sources
In the activation of a prothrombin solution, only part of the prothrombin becomes biothrombin, some becomes autoprothrombin I and some becomes autoprothrombin II. Thrombin-thrombin is also obtained, and perhaps other derivatives of prothrombin are formed. Prothrombin thus has multiple potentialities and these can be developed in diverse ways.
J A, PENNER, W H, SEEGERS
openaire +2 more sources
Prothrombin Metz : Purification and Characterization of a Variant of Human Prothrombin [PDF]
Thrombosis and Haemostasis, 1979 For the purification of the abnormal prothrombin (Pt Metz), advantage has been taken of the existence in the family of three siblings who, being double heterozygotes for Pt Metz and a hypoprothrombinemia, have no normal Pt. Purification procedures included barium citrate adsorption and chromatography on DEAE Sephadex as for normal Pt.
J Elion, M Ribieto, D Labie, F Josso
openaire +1 more source
Prothrombin Segovia: A new congenital abnormality of prothrombin
Scandinavian Journal of Haematology, 1986A family with a new congenital dysprothrombinemia is presented. The propositus is a 21‐yr‐old man who presented simultaneously with hemartrosis of the left knee and an extensive hematoma following a minor trauma. Prothrombin time and activated partial thromboplastin time were prolonged.
P. R. Fisac +5 more
openaire +3 more sources
Prothrombin Poissy: a new variant of human prothrombin
British Journal of Haematology, 1987SummaryA new congenital dysprothrombinaemia is described in a newborn baby girl who presented severe bleeding from the second day of life. Routine coagulation tests showed very prolonged prothrombin time and activated partial thromboplastin time with about 2% prothrombin activity in a one‐stage assay.
A. Bros +5 more
openaire +3 more sources
Polymorphisms in the Prothrombin Gene and their Association with Plasma Prothrombin Levels [PDF]
Thrombosis and Haemostasis, 2001 SummaryTo find genetic causes of high plasma prothrombin levels, an established prothrombotic risk factor, we searched for sequence variations in the prothrombin gene. We selected subjects with the 20210-GG genotype (since the 20210-A allele is already known to be associated with high levels) and elevated prothrombin levels (≥ 130 U/dl) from the Leiden
F.R. Rosendaal +4 more
openaire +2 more sources
Electroimmunoassay of prothrombin
Thrombosis Research, 1987Electroimmunoassay of normal (10-Gla) and Gla-deficient prothrombins containing 0 to 9 Gla (gamma-carboxyglutamyl) residues performed in EDTA against anti- (normal) prothrombin showed that each of the Gla-deficient proteins contained as much antigenic activity as does the normal molecule. In the presence of Ca2+, however, normal prothrombin appeared to
openaire +3 more sources
Congenital Prothrombin Deficiency
Seminars in Thrombosis and Hemostasis, 2009Prothrombin deficiency is among the rarest inherited coagulation disorders, with a prevalence of approximately 1:2,000,000. Two main phenotypes can be distinguished: (1) hypoprothrombinemia (type I deficiency), characterized by concomitantly low levels of activity and antigen; and (2) dysprothrombinemia (type II deficiency), characterized by the normal
Lancellotti, Stefano +1 more
openaire +4 more sources