Results 21 to 30 of about 17,204,946 (352)

NAFLD‐related hepatocellular carcinoma: The growing challenge

Hepatology, EarlyView., 2022
Risk and protective factors for NAFLD‐related hepatocellular carcinoma Abstract Hepatocellular carcinoma (HCC) is a common cause of cancer‐related mortality and morbidity worldwide. With the obesity pandemic, NAFLD‐related HCC is contributing to the burden of disease exponentially.
Pir Ahmad Shah, Rashmee Patil, Stephen A. Harrison   +2 more
wiley   +1 more source

Evaluating the analytical performance of five new coagulation assays for the measurement of prothrombin time and activated thromboplastin time

International Journal of Laboratory Hematology, 2018
New methods for coagulation tests require careful assessment before routine use. We evaluated the analytical performance of five new coagulation assays for measuring prothrombin time (PT) and activated partial thromboplastin time (aPTT).
S. Kitchen, U. Geisen, J. Kappelmayer, P. Quehenberger, J. Driess, Anna Lowe, Robert Jones, Jana G. Boehm, G. Miles, Gergely Rozsnyai   +9 more
semanticscholar   +1 more source

Multiomics identifies the link between intratumor steatosis and the exhausted tumor immune microenvironment in hepatocellular carcinoma

Hepatology, EarlyView., 2022
Steatotic HCC can be diagnosed by MRI and forms a pro‐tumor immune microenvironment with high expression of PD‐L1, M2 polarization of macrophages and activation of CAFs, which may be a good target for combined immunotherapy. Abstract Background and Aims Immunotherapy has become the standard‐of‐care treatment for hepatocellular carcinoma (HCC), but its ...
Hiroki Murai, Takahiro Kodama, Kazuki Maesaka, Shoichiro Tange, Daisuke Motooka, Yutaka Suzuki, Yasuyuki Shigematsu, Kentaro Inamura, Yoshihiro Mise, Akio Saiura, Yoshihiro Ono, Yu Takahashi, Yota Kawasaki, Satoshi Iino, Shogo Kobayashi, Masashi Idogawa, Takashi Tokino, Tomomi Hashidate‐Yoshida, Hideo Shindou, Masanori Miyazaki, Yasuharu Imai, Satoshi Tanaka, Eiji Mita, Kazuyoshi Ohkawa, Hayato Hikita, Ryotaro Sakamori, Tomohide Tatsumi, Hidetoshi Eguchi, Eiichi Morii, Tetsuo Takehara   +29 more
wiley   +1 more source

Clinical evaluation of whole blood prothrombin time (PT) and international normalized ratio (INR) using a Laser Speckle Rheology sensor

Scientific Reports, 2017
Prothrombin time (PT) and the associated international normalized ratio (INR) are routinely tested to assess the risk of bleeding or thrombosis and to monitor response to anticoagulant therapy in patients.
Markandey M. Tripathi, Satoru Egawa, A. Wirth, D. Tshikudi, E. V. Van Cott, S. Nadkarni   +5 more
semanticscholar   +1 more source

Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis

Hepatology, EarlyView., 2022
Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis. Abstract Background and Aims Nucleotide‐binding oligomerization domain‐like receptor‐family pyrin domain‐containing 3 (NLRP3) inflammasome activation has been shown to result in liver fibrosis.
Jana Knorr, Benedikt Kaufmann, Maria Eugenia Inzaugarat, Theresa Maria Holtmann, Lukas Geisler, Jana Hundertmark, Marlene Sophia Kohlhepp, Laela M. Boosheri, Daisy R. Chilin‐Fuentes, Amanda Birmingham, Kathleen M. Fisch, Joel D. Schilling, Sven H. Loosen, Christian Trautwein, Christoph Roderburg, Münevver Demir, Frank Tacke, Hal M. Hoffman, Ariel E. Feldstein, Alexander Wree   +19 more
wiley   +1 more source

Plasma Levels of Prothrombin Fragment F1+2, D-dimer and Prothrombin Time Correlate with Clinical Stage and Lymph Node Metastasis in Operable Gastric Cancer Patients [PDF]

Japanese Journal of Clinical Oncology, 2008
Hyuk-Chan Kwon, Sung Yong Oh, Sang‐Hyun Lee, Sung‐Hyun Kim, Jin‐Yeong Han, Rhun Yian Koh, M. C. Kim, Hee Ju Kim   +7 more
openalex   +2 more sources

A retrospective discussion of the prognostic value of combining prothrombin time(PT) and fibrinogen(Fbg) in patients with Hepatocellular carcinoma

Journal of Cancer, 2017
Aims: The levels of coagulation system tests have been studied in various cancers. In this study, our aim is to evaluate the prognostic value of pretreatment plasma coagulation tests in hepatocellular carcinoma (HCC) patients.
Xue-ping Wang, M. Mao, Zhonglian He, Lin Zhang, P. Chi, J. Su, Shuqin Dai, Wan-li Liu   +7 more
semanticscholar   +1 more source

Association between PT, PT-INR, and in-hospital mortality in critically ill patients with tumors: A retrospective cohort study

Frontiers in Public Health, 2023
ObjectivesProthrombin time (PT) and PT-INR are independent predictors of mortality in patients with cancer. The PT and PT-INR of cancer patients are independent predictive variables of mortality.
Jia-Dong Liang, Zuo-An Qin, Jin-Hao Yang, Chao-Fen Zhao, Chao-Fen Zhao, Chao-Fen Zhao, Qian-Yong He, Qian-Yong He, Qian-Yong He, Kai Shang, Yu-Xin Li, Xin-Yu Xu, Yan Wang   +12 more
doaj   +1 more source

Effect of Hypoxic Ischaemic Encephalopathy on Coagulation Profile in Neonates in a Tertiary Care Center, Agra- A Prospective Clinical Study

Indian Journal of Neonatal Medicine and Research, 2023
Introduction: Perinatal asphyxia is very common in developing countries. Coagulopathy occurs as a part of spectrum of multiorgan dysfunction following hypoxic insult.
Payal Mittal, Shehraz Firoz, Digvijay Ghangas, Sonia Bhatt   +3 more
doaj   +1 more source

Prothrombin time is predictive of low plasma prothrombin concentration and clinical outcome in patients with trauma hemorrhage: analyses of prospective observational cohort studies

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 2017
BackgroundFibrinogen and prothrombin have been suggested to become rate limiting in trauma associated coagulopathy. Administration of fibrinogen is now recommended, however, the importance of prothrombin to patient outcome is unknown.MethodsWe have ...
Clare A Balendran, A. Lövgren, K. Hansson, Karin Nelander, M. Olsson, K. Johansson, K. Brohi, D. Fries, A. Berggren   +8 more
semanticscholar   +1 more source