Results 31 to 40 of about 17,401,114 (355)

Sickle cell disease: Assessment of hemostasis parameters in steady-state patients at Tertiary Care Hospital, Indore, India

Biomedical and Biotechnology Research Journal, 2022
Background: The evidence from various studies showed that patients with sickle cell disease (SCD) have altered components of hemostasis such as platelet function, procoagulant, anticoagulant and fibrinolytic pathways, and modulate inflammation such as ...
Gajendra Kumar Gupta, Purnima Dey Sarkar, Rohit Manyal, Mithun Singh Rajput   +3 more
doaj   +1 more source

Combined use of Clauss and prothrombin time‐derived methods for determining fibrinogen concentrations: Screening for congenital dysfibrinogenemia

Journal of clinical laboratory analysis (Print), 2018
In this study, the significance of fibrinogen concentration assessed by a combination of Clauss and prothrombin time (PT)‐derived methods for screening for congenital dysfibrinogenemia were investigated, and the screening efficiency of fibrinogen PT ...
Liqun Xiang, Meiling Luo, Jie Yan, L. Liao, Weijie Zhou, Xue-lian Deng, D. Deng, P. Cheng, Fa-quan Lin   +8 more
semanticscholar   +1 more source

Multiomics identifies the link between intratumor steatosis and the exhausted tumor immune microenvironment in hepatocellular carcinoma

Hepatology, EarlyView., 2022
Steatotic HCC can be diagnosed by MRI and forms a pro‐tumor immune microenvironment with high expression of PD‐L1, M2 polarization of macrophages and activation of CAFs, which may be a good target for combined immunotherapy. Abstract Background and Aims Immunotherapy has become the standard‐of‐care treatment for hepatocellular carcinoma (HCC), but its ...
Hiroki Murai, Takahiro Kodama, Kazuki Maesaka, Shoichiro Tange, Daisuke Motooka, Yutaka Suzuki, Yasuyuki Shigematsu, Kentaro Inamura, Yoshihiro Mise, Akio Saiura, Yoshihiro Ono, Yu Takahashi, Yota Kawasaki, Satoshi Iino, Shogo Kobayashi, Masashi Idogawa, Takashi Tokino, Tomomi Hashidate‐Yoshida, Hideo Shindou, Masanori Miyazaki, Yasuharu Imai, Satoshi Tanaka, Eiji Mita, Kazuyoshi Ohkawa, Hayato Hikita, Ryotaro Sakamori, Tomohide Tatsumi, Hidetoshi Eguchi, Eiichi Morii, Tetsuo Takehara   +29 more
wiley   +1 more source

Perbedaan Pengaruh Pemberian Infus HES Dengan Berat Molekul 40 kD dan 200 kD Terhadap Plasma Prothrombin Time dan Partial Thromboplastin Time Kajian Pada Pasien Dengan Perdarahan Sampai 20% Estimated Blood Volume

JAI (Jurnal Anestesiologi Indonesia), 2009
Latar belakang: Pasien dengan operasi besar yang beresiko terjadi perdarahan semakin meningkat setiap tahun. HES dengan berat molekul besar mempertahankan hemodinamik lebih baik tetapi mengganggu faktor koagulasi.
Hari Hendriarto Satoto, Ery Leksana, Uripno Budiono   +2 more
doaj   +1 more source

A Combined Pharmacometrics Analysis of Biomarker Distribution Under Treatment With Standard- or Low-Dose Rivaroxaban in Real-World Chinese Patients With Nonvalvular Atrial Fibrillation

Frontiers in Pharmacology, 2022
Background: The rivaroxaban dose regimen for patients with nonvalvular atrial fibrillation (NVAF) is complex in Asia. Given the high interindividual variability and the risk of bleeding caused by rivaroxaban in Asians, the influencing factors and the ...
Nan Zhao, Nan Zhao, Zhiyan Liu, Qiufen Xie, Zhe Wang, Zhe Wang, Zhongyi Sun, Qian Xiang, Yimin Cui, Yimin Cui, Yimin Cui   +10 more
doaj   +1 more source

Are prothrombin time and clot waveform analysis useful in detecting a bleeding risk in liver cirrhosis?

International Journal of Laboratory Hematology, 2018
Prothrombin time is thought to be unreliable in cirrhotic patients to predict the risk of bleeding. We investigated whether prothrombin time ratio was an independent risk factor for bleeding alongside its clot waveform analysis.
M. Ruberto, F. Marongiu, O. Sorbello, A. Civolani, L. Demelia, D. Barcellona   +5 more
semanticscholar   +1 more source

Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis

Hepatology, EarlyView., 2022
Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis. Abstract Background and Aims Nucleotide‐binding oligomerization domain‐like receptor‐family pyrin domain‐containing 3 (NLRP3) inflammasome activation has been shown to result in liver fibrosis.
Jana Knorr, Benedikt Kaufmann, Maria Eugenia Inzaugarat, Theresa Maria Holtmann, Lukas Geisler, Jana Hundertmark, Marlene Sophia Kohlhepp, Laela M. Boosheri, Daisy R. Chilin‐Fuentes, Amanda Birmingham, Kathleen M. Fisch, Joel D. Schilling, Sven H. Loosen, Christian Trautwein, Christoph Roderburg, Münevver Demir, Frank Tacke, Hal M. Hoffman, Ariel E. Feldstein, Alexander Wree   +19 more
wiley   +1 more source

Evaluating the analytical performance of five new coagulation assays for the measurement of prothrombin time and activated thromboplastin time

International Journal of Laboratory Hematology, 2018
New methods for coagulation tests require careful assessment before routine use. We evaluated the analytical performance of five new coagulation assays for measuring prothrombin time (PT) and activated partial thromboplastin time (aPTT).
S. Kitchen, U. Geisen, J. Kappelmayer, P. Quehenberger, J. Driess, Anna Lowe, Robert Jones, Jana G. Boehm, G. Miles, Gergely Rozsnyai   +9 more
semanticscholar   +1 more source

The appearance of molecules of prothrombin origin in blood upon development of atherothrombotic and cardioembolic ischemic stroke

Vìsnik: Kiïvsʹkij Nacìonalʹnij Unìversitet Imenì Tarasa Ševčenka. Bìologìâ, 2016
Increase of molecules of prothrombin origin in patients with atherothrombotic and cardioembolic stroke subtypes had been shown. It was found the presence of protein fractions in the range of molecular weights corresponding to both prothrombin molecules ...
N. Raksha, M. Burlova-Vasylieva, E. Torgalo, O. Savchuk   +3 more
doaj   +1 more source

A retrospective discussion of the prognostic value of combining prothrombin time(PT) and fibrinogen(Fbg) in patients with Hepatocellular carcinoma

Journal of Cancer, 2017
Aims: The levels of coagulation system tests have been studied in various cancers. In this study, our aim is to evaluate the prognostic value of pretreatment plasma coagulation tests in hepatocellular carcinoma (HCC) patients.
Xueping Wang, M. Mao, Zhonglian He, Lin Zhang, P. Chi, J. Su, Shuqin Dai, Wan-li Liu   +7 more
semanticscholar   +1 more source