ProtoPred: Advancing Oncological Research Through Identification of Proto-Oncogene Proteins
IEEE Access, 2021 Proto-oncogenes are the genes that have the potential to transform normal cells into cancer cells as a result of mutations. They usually contain encoding of proteins whose function is to inhibit cell differentiation, stimulate cell division, and prevent ...
Sharaf J. Malebary +2 more
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Interplay of the Proto-oncogene Proteins CrkL and CrkII in Insulin-like Growth Factor-I Receptor-mediated Signal Transduction* [PDF]
Journal of Biological Chemistry, 1998 The closely related proto-oncogene proteins CrkII and CrkL consist of one SH2 and two SH3 domains and share 60% overall homology with the highest identity within their functional domains. In this study we show that CrkL and CrkII may play overlapping but
A. Koval, M. Karas, Y. Zick, D. Leroith
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Expression of Id proteins is regulated by the Bcl-3 proto-oncogene in prostate cancer [PDF]
Oncogene, 2012 B-cell leukemia 3 (Bcl-3) is a member of the inhibitor of κB family, which regulates a wide range of biological processes by functioning as a transcriptional activator or as a repressor of target genes. As high levels of Bcl-3 expression and activation have been detected in different types of human cancer, Bcl-3 has been labeled a proto-oncogene.
Ramin Massoumi +4 more
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Human proto-oncogene N-myc encodes nuclear proteins that bind DNA. [PDF]
Molecular and Cellular Biology, 1986 N-myc is a gene whose amplification has been implicated in the genesis of several malignant human tumors. We have identified two proteins with molecular weights of 65,000 and 67,000 encoded by N-myc. The abundance of these proteins in tumor cells was consonant with the extent of amplification of N-myc.
Lawrence W. Stanton +3 more
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Drosophila actin-Capping Protein limits JNK activation by the Src proto-oncogene [PDF]
Oncogene, 2013 The Src family kinases c-Src, and its downstream effectors, the Rho family of small GTPases RhoA and Jun N-terminal kinase (JNK) have a significant role in tumorigenesis. In this report, using the Drosophila wing disc epithelium as a model system, we demonstrate that the actin-Capping Protein (CP) αβ heterodimer, which regulates actin filament (F-actin)
Barbara Jezowska +2 more
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Expression and function of ras proto-oncogene proteins in human sperm cells [PDF]
Journal of Cell Science, 1992 ABSTRACT The presence and role of c-ras proteins were investigated in mature human sperm cells. The v-H-ras monoclonal antibody (mAh) against the c-ras protein, p21, reacted specifically with the acrosomal region of methanol-fixed as well as unfixed-live capacitated and non-capacitated human sperm cell in the indirect immunofluorescence ...
Rajesh K. Naz, Khaliq Ahmad, Paul Kaplan
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Transcriptional regulation of 1-cys peroxiredoxin by the proto-oncogene protein DEK
Molecular Medicine Reports, 2010 The nuclear phosphoprotein DEK is abundantly present in cells and is implicated in diseases including leukemia and autoimmune disorders. DEK has three highly acidic amino acid domains and inhibits histone acetyltransferase activity by binding directly to histones.
Sulji Choi +5 more
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Correlation of long interspersed element-1 open reading frame 1 and c-Met proto-oncogene protein expression in primary and recurrent colorectal cancers [PDF]
Kosin Medical Journal, 2022 Background Colorectal cancer is one of the most common cancers worldwide. Colorectal cancer that has recurred and metastasized to other organs also has a very poor prognosis.
Kyung-Yoon Jeon +6 more
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BRAFV600E Mutation Enhances Estrogen-Induced Metastatic Potential of Thyroid Cancer by Regulating the Expression of Estrogen Receptors [PDF]
Endocrinology and Metabolism, 2022 Background Cross-talk between mitogen-activated protein kinase and estrogen has been reported; however, the role of BRAFV600E in the estrogen responsiveness of thyroid cancer is unknown.
Minjun Kim +8 more
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