Results 11 to 20 of about 440,834 (358)
ProtoPred: Advancing Oncological Research Through Identification of Proto-Oncogene Proteins [PDF]
IEEE Access, 2021 Proto-oncogenes are the genes that have the potential to transform normal cells into cancer cells as a result of mutations. They usually contain encoding of proteins whose function is to inhibit cell differentiation, stimulate cell division, and prevent ...
Sharaf J. Malebary +2 more
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Structure-specific binding of the proto-oncogene protein DEK to DNA [PDF]
Nucleic Acids Research, 2003 The ubiquitous proto-oncogene protein DEK has been found to be associated with chromatin during the entire cell cycle. It changes the topology of DNA in chromatin and protein-free DNA through the introduction of positive supercoils. The sequence and structure specificities of DEK-DNA interactions are not completely understood. The binding of DEK to DNA
Tanja Waldmann
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Human proto-oncogene N-myc encodes nuclear proteins that bind DNA. [PDF]
Molecular and Cellular Biology, 1986 N-myc is a gene whose amplification has been implicated in the genesis of several malignant human tumors. We have identified two proteins with molecular weights of 65,000 and 67,000 encoded by N-myc. The abundance of these proteins in tumor cells was consonant with the extent of amplification of N-myc.
G, Ramsay +3 more
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The protein encoded by the human proto-oncogene c-myc. [PDF]
Proceedings of the National Academy of Sciences, 1984 The proto-oncogene c-myc may play a role in controlling the growth and division of normal cells, and abnormalities of the gene have been implicated in the genesis of a substantial variety of human tumors. To facilitate further study of these issues, we developed antisera that permit the identification and isolation of the protein encoded by the human ...
G, Ramsay, G I, Evan, J M, Bishop
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Drosophila actin-Capping Protein limits JNK activation by the Src proto-oncogene [PDF]
Oncogene, 2013 The Src family kinases c-Src, and its downstream effectors, the Rho family of small GTPases RhoA and Jun N-terminal kinase (JNK) have a significant role in tumorigenesis. In this report, using the Drosophila wing disc epithelium as a model system, we demonstrate that the actin-Capping Protein (CP) αβ heterodimer, which regulates actin filament (F-actin)
Beatriz García Fernández +2 more
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T cell recognition of transforming proteins encoded by mutated ras proto-oncogenes [PDF]
The Journal of Immunology, 1991 Abstract Activated ras proto-oncogenes contribute to the pathogenesis of many animal and human malignancies. ras proto-oncogenes are generally activated by point mutations within codons 12 or 61, which result in the expression of ras protein (p21) bearing characteristic single amino acid substitutions at the corresponding residues.
David Peace +3 more
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Transcriptional regulation of 1-cys peroxiredoxin by the proto-oncogene protein DEK
Molecular Medicine Reports, 2010 The nuclear phosphoprotein DEK is abundantly present in cells and is implicated in diseases including leukemia and autoimmune disorders. DEK has three highly acidic amino acid domains and inhibits histone acetyltransferase activity by binding directly to histones.
Seo
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