Results 41 to 50 of about 197,127 (261)
Frequency of Expression of BRAF V600E and Epidermal Growth Factor Receptor (EGFR) in Ameloblastoma
Asian Pacific Journal of Cancer Biology, 2022 Objective: To determine the Immunohistochemical expression of BRAF V600E and Epidermal growth factor receptor (EGFR) in ameloblastoma and correlate the expression with age and gender of patients, and patterns and types of ameloblastoma.
Namrah Bashir +7 more
doaj +1 more source
A novel role for nonactin: interfering with G-quadruplex in RET-driven medullary thyroid cancer. [PDF]
BMC CancerBackground Medullary Thyroid Carcinoma (MTC) is closely associated with mutations in the RET proto-oncogene, placing the activated RET protein at the center of MTC pathogenesis. Existing therapeutic solutions, primarily tyrosine kinase inhibitors such as
Alqahtani T +7 more
europepmc +2 more sources
Arquivos de Gastroenterologia, 2005 BACKGROUND: Higher proliferation is commonly observed in cancer cells. Apoptosis can be a useful measure of a tumor cell kinetic. Alteration of the balance between proliferation and apoptosis is associated with cancer.
Nora Manoukian Forones +4 more
doaj +1 more source
In silico evidence that protein unfolding is as a precursor of the protein aggregation [PDF]
ChemPhysChem 2020, 21, 377, 2019 We present a computational study on the folding and aggregation of proteins in aqueous environment, as function of its concentration. We show how the increase of the concentration of individual protein species can induce a partial unfolding of the native conformation without the occurrence of aggregates. A further increment of the protein concentration
arxiv +1 more source
A novel methodology on distributed representations of proteins using their interacting ligands [PDF]
Bioinformatics 2018, 2018 The effective representation of proteins is a crucial task that directly affects the performance of many bioinformatics problems. Related proteins usually bind to similar ligands. Chemical characteristics of ligands are known to capture the functional and mechanistic properties of proteins suggesting that a ligand based approach can be utilized in ...
arxiv +1 more source
Synthesis of proto-oncogene proteins and cyclins depends on intact microfilaments
European Journal of Cell Biology, 1998 It is well established that microfilament disintegration by cytochalasin D (CD) as well as latrunculin (LAT)-A and LAT-B causes an inhibition of S phase entry of various nontransformed cell lines. Our experiments extended these observations to human embryonal diploid fibroblasts (Wi-38). To investigate the question whether this stop of DNA synthesis is
Martin Iwig +2 more
openaire +3 more sources
The neural ELAVL protein HuB enhances endogenous proto-oncogene activation [PDF]
Biochemical and Biophysical Research Communications, 2019 The cytoplasmic distribution of the HuR/ELAVL1 (embryonic lethal abnormal vision 1) protein is recognized as an important prognostic factor of malignant tumors. However, the previous study suggests that exogenous over-expression of HuR is not sufficient for nuclear export.
Tomoyuki Hatanaka +3 more
openaire +3 more sources
Effect and mechanism of Juluo decoction combined with Ruhe powder in treatment of rat model of hyperplasia of mammary glands [PDF]
精准医学杂志Objective To investigate the effect and mechanism of Juluo Decoction combined with Ruhe Powder in the treatment of rat model of hyperplasia of mammary glands.
NIE Weihong, LIU Hongxi, SUN Guoxin, LIU Chengcong, ZOU Xiao
doaj +1 more source
Mutation Profile of Well-Differentiated Thyroid Cancer in Asians [PDF]
Endocrinology and Metabolism, 2015 Recent advances in molecular diagnostics have led to significant insights into the genetic basis of thyroid tumorigenesis. Among the mutations commonly seen in thyroid cancers, the vast majority are associated with the mitogen-activated protein kinase ...
Young Shin Song +2 more
doaj +1 more source
DiagnosticsMicrosatellite Instability (MSI-H) occurs in approximately 15% of non-metastatic colon cancers, influencing patient outcomes positively compared to microsatellite stable (MSS) cancers. This systematic review focuses on the prognostic significance of KRAS,
Elena Orlandi +7 more
doaj +1 more source