Results 71 to 80 of about 440,834 (358)

The FnBPA from methicillin-resistant Staphylococcus aureus promoted development of oral squamous cell carcinoma

Journal of Oral Microbiology, 2022
Background Oral squamous cell carcinoma (OSCC) is the most common tumor in the oral cavity. Methicillin-resistant Staphylococcus aureus (MRSA) were highly detected in OSCC patients; however, the interactions and mechanisms between drug-resistant bacteria
Li-Xin Kong, Zheng Wang, Yu-Ke Shou, Xue-Dong Zhou, Ya-Wen Zong, Ting Tong, Min Liao, Qi Han, Yan Li, Lei Cheng, Biao Ren   +10 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Histopathologic classification and immunohistochemical features of papillary renal neoplasm with potential therapeutic targets [PDF]

Journal of Pathology and Translational Medicine
Background Papillary renal cell carcinoma (pRCC) is the second most common histological subtype of renal cell carcinoma and is considered a morphologically and molecularly heterogeneous tumor.
Jeong Hwan Park, Su-Jin Shin, Hyun-Jung Kim, Sohee Oh, Yong Mee Cho   +4 more
doaj   +1 more source

Point mutations of the P53 gene, human hepatocellular carcinoma and aflatoxins [PDF]

, 1993
The tumor suppressor p53 exerts important protective functions towards DNA-damaging agents. Its inactivation by allelic deletions or point mutations within the P53 gene as well as complex formation of wildtype p53 with cellular or viral proteins is a ...
Alexander L. Gerbes, Aoyama, Barak, Bressac, Bressac, Buetow, Caselmann, Challen, Colombo, Donehower, Fields, Finlay, Foster, Halevy, Hsu, Jenkins, Kastan, Kekulé, Kew, Kress, Lane, Laurent-Puig, Lilleberg, Livingstone, Ludlow, Malkin, Marshall, Meyer, Meyer, Mueller, Murakami, Nigro, Ozturk, Raycroft, Sarnow, Slagle, Srivastava, Sturzbecher, Taylor, Wolfgang H. Caselmann, Wollersheim   +40 more
core   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Alternative Translation of the Proto-oncogene c-mycby an Internal Ribosome Entry Site*

Journal of Biological Chemistry, 1997
The human proto-oncogene c-mycencodes two proteins, c-Myc1 and c-Myc2, from two initiation codons, CUG and AUG, respectively. It is also transcribed from four alternative promoters (P0, P1, P2, and P3), giving rise to different RNA 5′-leader sequences ...
C. Nanbru, I. Lafon, S. Audigier, M. Gensac, S. Vagner, G. Huez, A. Prats   +6 more
semanticscholar   +1 more source

Risk factors analysis for BRAF gene V600E mutation in patients with infiltrative follicular papillary thyroid carcinoma [PDF]

精准医学杂志
Objective To investigate the risk factors for BRAF gene V600E mutation in patients with infiltrative follicular papillary thyroid carcinoma (IF-PTC). Methods A total of 134 patients with IF-PTC who underwent surgical treatment in our hospital from August
LI Lei, ZHAN Jiezhi, LI Hui, WANG Ruiqing, ZHAO Cheng
doaj   +1 more source

MicroRNA miR-212-5p Regulates the MEK/ERK Signaling Pathway by Targeting A-Raf proto-oncogene serine/threonine-protein kinase (ARAF) to Regulate Cowshed PM2.5-Induced NR8383 Apoptosis [PDF]

, 2023
Ke Sun, Yize Sun, Yunna Jia, Xinran Duan, Zhenhua Ma, Xiqing Zhang, Lixia Wang, Yanbin Zhu, Yunhang Gao, Wangdui Basang   +9 more
openalex   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

The Effects of a Submaximal Endurance Swimming Training Period and Cadmium Poisoning during Pregnancy on the Hepatocyte Growth Factor Response in Neonatal Rats

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2015
Background and Objectives: Exposure to cadmium in early pregnancy has long-term effects on the growth and function of the liver. One of the pathways that controls proliferation of the fetal liver involves hepatocyte growth factor (HGF).
Hossein Ali Asgharzade Oliaei, Shadmehr Mirdar Harijani, Narges Mousavi   +2 more
doaj