Results 81 to 90 of about 384,382 (347)

Mitochondrial superoxide dismutase controls metabolic plasticity in pancreatic cancer

Cell Communication and Signaling
Background The role of reactive oxygen species (ROS) in cancer is debated. One main antioxidant enzyme is mitochondrial superoxide dismutase (SOD2) which has been shown to influence tumor initiation and metastatic progression in several cancer types ...
Sankaranarayanan Ramasubramanian, Rupert Öllinger, Carola Eberhagen, Hans Zischka, Roland M. Schmid, Henrik Einwächter   +5 more
doaj   +1 more source

Expression and regulatory effects on cancer cell behavior of NELL1 and NELL2 in human renal cell carcinoma [PDF]

, 2015
We thank Professors Michael Rehli, Yoshiaki Ito, and Kristian Helin for gifting plasmids, Dr. Alasdair MacKenzie (University of Aberdeen) for helpful discussion, and Mr. Takashi Mizukami, Ms. Ryoko Tokuda, and Ms.
Mizokami, Atsushi, Nakamoto, Masaru, Nakamura, Ritsuko, Namiki, Mikio, Ooi, Akishi, Oyama, Takeru, Tajiri, Ryosuke   +6 more
core   +1 more source

Human proto-oncogene N-myc encodes nuclear proteins that bind DNA. [PDF]

Molecular and Cellular Biology, 1986
N-myc is a gene whose amplification has been implicated in the genesis of several malignant human tumors. We have identified two proteins with molecular weights of 65,000 and 67,000 encoded by N-myc. The abundance of these proteins in tumor cells was consonant with the extent of amplification of N-myc.
G, Ramsay, L, Stanton, M, Schwab, J M, Bishop   +3 more
openaire   +2 more sources

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Study of MDM2 Promoter Polymorphism(SNP309) in Breast Cancer Patients in an Iranian Population

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2011
Introduction: Immunological processes play an important role in recurrent spontaneous abortion(RSA). According to studies, T lymphocytes and natural killer cells(NK cells) are two effective cell groups in RSA.
M Hossein Pour Feizi, S Taghizadeh, N Poulad, P Azarfam, V Montazeri   +4 more
doaj  

miRNAs link metabolic reprogramming to oncogenesis [PDF]

, 2013
The most profound biochemical phenotype of cancer cells is their ability to metabolize glucose to lactate, even under aerobic conditions. This alternative metabolic circuitry is sufficient to support the biosynthetic and energy requirements for cancer ...
Hatziapostolou, M, Iliopoulos, D, Polytarchou, C   +2 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Sperm-Egg Binding Protein or Proto-Oncogene? [PDF]

Science, 1996
J Y, Tsai, L M, Silver
openaire   +5 more sources

Decoding HiPSC-CM’s Response to SARS-CoV-2: mapping the molecular landscape of cardiac injury

BMC Genomics
Background Acute cardiac injury caused by coronavirus disease 2019 (COVID-19) increases mortality. Acute cardiac injury caused by COVID-19 requires understanding how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) directly infects ...
Sicheng Chen, Zhenquan Fu, Kaitong Chen, Xinyao Zheng, Zhenyang Fu   +4 more
doaj   +1 more source

Point mutations of the P53 gene, human hepatocellular carcinoma and aflatoxins [PDF]

, 1993
The tumor suppressor p53 exerts important protective functions towards DNA-damaging agents. Its inactivation by allelic deletions or point mutations within the P53 gene as well as complex formation of wildtype p53 with cellular or viral proteins is a ...
Alexander L. Gerbes, Aoyama, Barak, Bressac, Bressac, Buetow, Caselmann, Challen, Colombo, Donehower, Fields, Finlay, Foster, Halevy, Hsu, Jenkins, Kastan, Kekulé, Kew, Kress, Lane, Laurent-Puig, Lilleberg, Livingstone, Ludlow, Malkin, Marshall, Meyer, Meyer, Mueller, Murakami, Nigro, Ozturk, Raycroft, Sarnow, Slagle, Srivastava, Sturzbecher, Taylor, Wolfgang H. Caselmann, Wollersheim   +40 more
core   +1 more source