Bone morphogenetic proteins (BMP‐2 and BMP‐3) induce the late phase expression of the proto‐oncogene c‐fos in murine osteoblastic MC3T3‐E1 cells [PDF]
FEBS Letters, 1992 Here we report that bone morphogenetic proteins 2 and 3 (BMP‐2 and BMP‐3) induced marked expression of c‐fos mRNA in a biphasic manner, i.e. the late phase (48 to 60 h) as well as the immediate‐early phase (0.5 h), in murine osteoblastic MC3T3‐El cells in vitro.
Shuichi Ohta +12 more
semanticscholar +6 more sources
Helicobacter pylori Activates Mitogen-activated Protein Kinase Cascades and Induces Expression of the Proto-oncogenes c-fos and c-jun [PDF]
Journal of Biological Chemistry, 2000 Helicobacter pylori is an etiological agent in the development of mucosa-associated lymphoid tissue lymphoma and gastric adenocarcinoma. Patients infected with H. pylori carry a 3-6-fold increased risk of developing cancer compared with uninfected individuals. H.
Tobias Meyer‐ter‐Vehn +3 more
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The deazaguanine‐derivative, queuine, affects cell proliferation, protein phosphorylation and the expression of the proto oncogenes c‐fos and c‐myc in HeLa cells [PDF]
FEBS Letters, 1990 In higher eukaryotes the hypermodified guanine analogue, queuine (7‐(5‐(((1S,4S,5R)‐4,5‐dihydroxy‐2‐cyclopentene‐1‐yl)amino)‐methyl)‐7‐deazaguanine), occurs free or as modified nucleoside (Q) in the anticodon of specific tRNAs. Fast proliferating tissues and tumors contain considerable amounts of free queuine and Q‐deficient tRNAs.
Werner Langgut, H. Kersten
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Proto-Oncogene c-fos Is Transcriptionally Regulated by Parathyroid Hormone (PTH) and PTH-Related Protein in a Cyclic Adenosine Monophosphate-Dependent Manner in Osteoblastic Cells [PDF]
Endocrinology, 1997 PTH and PTH-related protein (PTHrP) bind to the PTH-1 (PTH/PTHrP) receptor and produce anabolic and catabolic effects in bone. To investigate postreceptor mechanisms of action, MC3T3-E1 cells were induced to differentiate to optimize PTH-1 receptor expression, and differentiated MC3T3-E1 cells were treated with varying doses of PTH (1-34) for 1 h ...
Laurie K. McCauley
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Activation of endogenous c-fos proto-oncogene expression by human T-cell leukemia virus type I-encoded p40tax protein in the human T-cell line, Jurkat [PDF]
Journal of Virology, 1989 We examined the ability of the trans-acting factor p40tax of human T-cell leukemia virus type I (HTLV-I), which is thought to be a crucial molecule in T-cell transformation by HTLV-I, to activate expression of a set of endogenous cellular genes related to T-cell proliferation.
Keiko Nagata +3 more
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Journal of Cardiovascular Pharmacology, 1992 Endothelins (ETs) are potent regulatory peptides that cause numerous phenotypic changes in glomerular mesangial cells including differential regulation of gene expression and mitogenesis. Although the second messengers produced by activated ET receptors are well characterized, little is known about pathways of nuclear signaling.
Michael S. Simonson +3 more
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Role of protein kinase C and cyclic adenosine monophosphate in the regulation of tissue-type plasminogen activator, plasminogen activator inhibitor-1, and platelet-derived growth factor mRNA levels in human endothelial cells. Possible involvement of proto-oncogenes c-jun and c-fos. [PDF]
Arteriosclerosis and Thrombosis: A Journal of Vascular Biology, 1991 Activation of protein kinase C leads to a strong induction of tissue-type plasminogen activator (t-PA) expression in endothelial cells. Using endothelial cells from human umbilical vein (HUVECs) and human aorta (HAECs), we have studied this regulation of t-PA and its inhibitor, plasminogen activator inhibitor-1 (PAI-1), at the mRNA level and have ...
T. Kooistra +7 more
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Hexachlorobenzene-Induced Early Changes in Ornithine Decarboxylase and Protein Tyrosine Kinase Activities, Polyamines and c-Myc, c-Fos and c-Jun Proto-Oncogenes in Rat Liver [PDF]
Toxicological Sciences, 2003 El hexaclorobenceno (HCB) es un compuesto químico lipófilo que se distribuye ampliamente en el medio ambiente. Se sabe que el HCB causa tumores hepáticos en animales de experimentación. En el presente estudio se investigó el efecto in vivo del tratamiento con HCB sobre las actividades de la ornitina descarboxilasa (ODC) y la proteína tirosina quinasa ...
Andrea Randi
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FEBS Letters, 1991 Here we report marked in vivo expression of the c‐fos gene in the external soft callus (ESC) and periosteal hard callus (PHC) at the fracture site of adult rat tibia. Northern‐blot analysis showed that the ESC expressed a high level of c‐fos mRNA from post‐fracture day 10 to day 28, the time when endochondral ossification progressed, and that the ...
Shuichi Ohta +9 more
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Epidermal Growth Factor Stimulation of Stromelysin mRNA in Rat Fibroblasts Requires Induction of Proto-Oncogenes c-fos and c-jun and Activation of Protein Kinase C [PDF]
Molecular and Cellular Biology, 1990 Stromelysin (transin) is a secreted metalloprotease that is transcriptionally induced by a variety of growth factors and oncogenes. We examined the necessity of specific secondary (protein kinase C) and tertiary (c-fos and c-jun protein products) messengers in the transactivation of stromelysin gene expression by epidermal growth factor (EGF).
Susan McDonnell +2 more
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