Results 31 to 40 of about 34,702 (148)

Transcriptional and posttranscriptional regulation of human androgen receptor expression by androgen. [PDF]

, 1993
Autoregulation is a control mechanism common to several proteins of the steroid/thyroid hormone receptor superfamily. In this work the effect of androgens and antiandrogens on the expression of the human androgen receptor (hAR) in prostate and breast ...
Blasschke, Dorothea, Hermeking, Heiko, Herzinger, Thomas, Hörz, Wolfram, Wolf, Dieter A.   +4 more
core   +1 more source

NFS1 Regulates IDH2 to Attenuate Abdominal Aortic Aneurysms via Interacting With SP2

Advanced Science, EarlyView.
The loss of NFS1 leads to its reduced binding with the transcription factor SP2, resulting in decreased expression of the downstream gene Idh2. This causes a shift in energy supply toward glycolysis in VSMCs, ultimately contributing to the occurrence and progression of AAA.
Luzheng Zhang, Yu Zhang, Dezhong Wen, Suxiang Guo, Xiaohui Qi, Heng Wang, Yujin Sun, Guangdong Yang, Yuehong Wang, Song Xue   +9 more
wiley   +1 more source

Ermittlung der m-RNA-Expressionsmuster der c-jun, c-fos und c-myc Proto-Onkogene nach ex vivo Ballondilatation von Schweinekarotiden mittels semiquantitativer RT-PCR. [PDF]

, 2005
Ziel der Arbeit war die Ermittlung der mRNA Muster dreier Proto-Onkogene nach Ballondilatation in einem serumfreien Modell mit Hilfe einer zu etablierenden semiquantitativen RT PCR ohne die Verwendung radioaktiver oder fluoreszierender Substanzen ...
Alfke, Heiko (Dr.), Steinhagen, Sandra
core   +1 more source

Hepatocyte BPGM Induces RET Lactylation and Macrophage Reprogramming to Promote Tumorigenesis in Hepatocellular Carcinoma

Advanced Science, EarlyView.
Mechanistic schematic diagram.BPGM promotes the expression level of RET by increasing the lactylation of RET‐K549 and inhibiting its ubiquitination levels in HCC cells. Furthermore, BPGM in HCC cells could also promote M2 polarization in macrophages through lactate secretion. Both of the mechanisms could promote the progression of HCC. ABSTRACT Aerobic
Jiajia Zhang, Lu Shi, Liangliang Lin, Yang Zhang, Miao Zhang, Lili Wu, Yong Xia, Yaqiong Zhang, Peng Han, Likun Zhuang, Liang Shi   +10 more
wiley   +1 more source

Emerging roles of ATF2 and the dynamic AP1 network in cancer [PDF]

, 2010
Cooperation among transcription factors is central for their ability to execute specific transcriptional programmes. The AP1 complex exemplifies a network of transcription factors that function in unison under normal circumstances and during the course ...
A Behrens, A Behrens, A Bhoumik, A Bhoumik, A Bhoumik, A Bhoumik, A Bhoumik, A Brozovic, A Bruhat, A Gallo, A Laine, A Okuda, A Sunters, A Sunters, AJ Berger, AJ Whitmarsh, AM Bamberger, AM Musti, AM Reimold, AS Nateri, B Binetruy, B Dérijard, BB Aggarwal, BJ Ledwith, BK Prusty, BM Hagmeyer, BW Ozanne, C Weiss, CC Franklin, CC Huang, CE Malnou, CJ Chalmers, CJ Kara, CP Matthews, D De Cesare, D Jean, D Siegmund, DJ Papachristou, DJ Toft, DM Ouwens, DS Vale-Cruz, DW Lin, E Bossy-Wetzel, E Drakos, E Passegue, E Passegue, E Reichmann, E Shaulian, E Shaulian, E Stepniak, E Szabo, E Tulchinsky, Eric Lau, F Beier, F Hilberg, F Hommura, F Mechta, F Mechta-Grigoriou, F Talotta, FP Lemaigre, G Bergers, G Bossis, G Cirillo, G Tessari, G Zhang, G Zhang, GT Bowden, H Kawasaki, H Liu, H Song, H van Dam, H van Dam, H Wang, HA Abdel-Hafiz, HS Kim, I Herr, I Kinoshita, IE Wertz, IS Woo, J Bailey, J Basbous, J Basbous, J Cheng, J Garaude, J Ham, J Kool, J Ming, J Rangatia, J Takeda, J Westermarck, JB Weitzman, JCG Sng, JS Lewis, JY Zhang, K Belguise, K Georgopoulos, K Hettinger, K Kovary, K Maeno, K Milde-Langosch, K Ozawa, K Podar, K Sabapathy, K Sabapathy, KD Chen, KJ Flint, KU Jooss, L Bakiri, L Daury, LA Penix, LJ Ransone, M Agelopoulos, M Ameyar-Zazoua, M Assimakopoulou, M Assimakopoulou, M Chu, M Karin, M Katabami, M Mikula, M Olive, M Santaguida, M Schreiber, MA Read, ME Astruc, ME Greenberg, ME Ramos-Nino, MJ Pellegrino, ML Graves, MM Vleugel, MR Young, MR Young, MW Mayo, N Kalra, N Wang, NH Heintz, NR Bhat, NV Shirsat, O Kustikova, O Mariani, P Adiseshaiah, P Angel, P Angel, P Angel, P Lopez-Bergami, P Papassava, Pablo Lopez-Bergami, PK Vogt, Q Ma, Q Shen, R Chiu, R Eferl, R Eferl, R Eferl, R Farras, R Firestein, R Johnson, R Suto, R Wisdom, R Zenz, RJ Davis, RP Ryseck, RR Acay, S Abbas, S Gupta, S Huguier, S Katiyar, S Knippen, S Langer, S Leppa, S Linardopoulos, S Mahner, S Mathas, S Morton, SA Vlahopoulos, SE Adunyah, SE Rutberg, SK Agarwal, SK Manna, SP Jin, SY Chen, SY Chen, SY Fuchs, SY Fuchs, SY Fuchs, T Akimoto, T Deng, T Hai, T Jenuwein, T Kallunki, T Maekawa, T Maekawa, T Maekawa, T Nakamura, T Shiratsuchi, T Suzuki, T Tanos, T Yamasaki, TD Halazonetis, TK Kerppola, TN Lively, TV Pospelova, TW Hai, U Fried, UR Rapp, V Ramirez-Carrozzi, V Zoumpourlis, W Breitwieser, W Jochum, W Jochum, W Lee, W Li, W Wei, W Wei, W Zhang, WH Landschulz, X Deng, X Jin, X Mao, X Ouyang, XY Li, Y Chinenov, Y Maki, Y Shimizu, Y Wo, Y Zhang, Y-N Wang, YM Janssen, Z Ronai, Ze'ev Ronai   +228 more
core   +1 more source

Integrative single cell RNA‐sequencing and spatial transcriptomics uncovers distinct macrophage‐fibroblast cross‐talk in human hip synovium between patients with femoroacetabular impingement and osteoarthritis

Arthritis &Rheumatology, Accepted Article.
Objectives Femoroacetabular impingement (FAI) and synovitis have been recognized as essential factors for developing osteoarthritis (OA) in the hip joints. However, little is known about altered synovial cellular compositions, their associated transcriptomic profiles, and cell‐cell interactions in FAI and hip OA.
Gulzada Kulzhanova, Alexis Klee, Mina Botros, Victoria L. Hansen, John Reuter, Eliya Tazreena Tashbib, Eloise Fadial, Benjamin F. Ricciardi, Brian Giordano, Chia‐Lung Wu   +9 more
wiley   +1 more source

Functions of p120ctn in development and disease [PDF]

, 2012
p120 catenin (p120ctn), a component of the cadherin-catenin complex, was the first member to be identified in a most interesting subfamily of the Armadillo family. Several p120ctn isoforms are generated by alternative splicing.
Pieters, Tim, van Hengel, Jolanda, Van Roy, Frans   +2 more
core   +1 more source

2D copper nanozyme patches facilitate bone regeneration via interfacial modulation of osteoclast‐osteoblast dynamics

BMEMat, EarlyView.
This study develops a nano‐enzyme patch (ezPatch) targeting bone interfaces. Utilizing ligand‐to‐metal charge transfer (LMCT) catalysis and bone‐targeting ligands on copper nanosheets, ezPatch simultaneously scavenges reactive oxygen species (ROS) and generates oxygen in situ at bone‐losing sites.
Yi Chen, Haoyue Hu, Danyang Wang, Ying Wang, Zhibang Li, Xiaoyi Liu, Yandi Zhang, Junkun Feng, Weiwei Zhao, Kai Li, Qi‐Zhi Zhong, Shaohua Ge, Jianhua Li   +12 more
wiley   +1 more source

Systemic activation of activin A signaling causes chronic kidney disease-mineral bone disorder [PDF]

, 2018
The high cardiovascular mortality associated with chronic kidney disease (CKD) is caused in part by the CKD-mineral bone disorder (CKD-MBD) syndrome.
Sugatani, Toshifumi
core   +2 more sources

Intrathecal Amylin and Salmon Calcitonin Affect Formalin Induced c-Fos Expression in the Spinal Cord of Rats

Iranian Journal of Medical Sciences, 2014
Background:Amylin and Salmon Calcitonin belong to the calcitonin family of peptides and have high affinity binding sites in the rat spinal cord. The aim of this study was to characterize receptors for Amylin and Salmon Calcitonin functionally in the ...
Zahra Khoshdel, Mohammad Ali Takhshid, Ali Akbar Owji   +2 more
doaj