Results 31 to 40 of about 34,292 (160)

Systemic activation of activin A signaling causes chronic kidney disease-mineral bone disorder [PDF]

, 2018
The high cardiovascular mortality associated with chronic kidney disease (CKD) is caused in part by the CKD-mineral bone disorder (CKD-MBD) syndrome.
Sugatani, Toshifumi
core   +2 more sources

Microcystin-leucine arginine causes cytotoxic effects in sertoli cells resulting in reproductive dysfunction in male mice [PDF]

, 2016
2016-2017 > Academic research: refereed > Publication in refereed journal201804_a bcmaVersion of ...
Chen, YB, Han, X, Li, DM, Wang, J, Wang, LH, Zhou, Y, Zou, X   +6 more
core   +1 more source

DKK3 Initially Preserves Acinar Integrity Through MEK‐Fos Signaling, but Later Switches to an Oncogenic Role in Pancreatic Cancer

Advanced Science, EarlyView.
In pancreatic cancer, the protein DKK3 is found to play a complex role: it initially slows early tumor growth but later promotes tumor aggressiveness. DKK3 expression evolves during progression and drives cancer severity by orchestrating cellular and molecular signaling pathways.
Dharini Srinivasan, Elodie Roger, Lukas Perkhofer, Eleni Zimmer, Thomas F.E. Barth, Julia P. Mosler, Anna Härle, Stephanie E. Weissinger, Nadine T. Gaisa, Peter Möller, Nico Fischer, Chantal Allgöwer, J.‐Matthias Löhr, Dirk Grimm, Thomas Seufferlein, Stefan Liebau, Ninel Azoitei, Michael K. Melzer, Frank Arnold, Johann Gout, Alexander Kleger   +20 more
wiley   +1 more source

Emerging roles of ATF2 and the dynamic AP1 network in cancer [PDF]

, 2010
Cooperation among transcription factors is central for their ability to execute specific transcriptional programmes. The AP1 complex exemplifies a network of transcription factors that function in unison under normal circumstances and during the course ...
A Behrens, A Behrens, A Bhoumik, A Bhoumik, A Bhoumik, A Bhoumik, A Bhoumik, A Brozovic, A Bruhat, A Gallo, A Laine, A Okuda, A Sunters, A Sunters, AJ Berger, AJ Whitmarsh, AM Bamberger, AM Musti, AM Reimold, AS Nateri, B Binetruy, B Dérijard, BB Aggarwal, BJ Ledwith, BK Prusty, BM Hagmeyer, BW Ozanne, C Weiss, CC Franklin, CC Huang, CE Malnou, CJ Chalmers, CJ Kara, CP Matthews, D De Cesare, D Jean, D Siegmund, DJ Papachristou, DJ Toft, DM Ouwens, DS Vale-Cruz, DW Lin, E Bossy-Wetzel, E Drakos, E Passegue, E Passegue, E Reichmann, E Shaulian, E Shaulian, E Stepniak, E Szabo, E Tulchinsky, Eric Lau, F Beier, F Hilberg, F Hommura, F Mechta, F Mechta-Grigoriou, F Talotta, FP Lemaigre, G Bergers, G Bossis, G Cirillo, G Tessari, G Zhang, G Zhang, GT Bowden, H Kawasaki, H Liu, H Song, H van Dam, H van Dam, H Wang, HA Abdel-Hafiz, HS Kim, I Herr, I Kinoshita, IE Wertz, IS Woo, J Bailey, J Basbous, J Basbous, J Cheng, J Garaude, J Ham, J Kool, J Ming, J Rangatia, J Takeda, J Westermarck, JB Weitzman, JCG Sng, JS Lewis, JY Zhang, K Belguise, K Georgopoulos, K Hettinger, K Kovary, K Maeno, K Milde-Langosch, K Ozawa, K Podar, K Sabapathy, K Sabapathy, KD Chen, KJ Flint, KU Jooss, L Bakiri, L Daury, LA Penix, LJ Ransone, M Agelopoulos, M Ameyar-Zazoua, M Assimakopoulou, M Assimakopoulou, M Chu, M Karin, M Katabami, M Mikula, M Olive, M Santaguida, M Schreiber, MA Read, ME Astruc, ME Greenberg, ME Ramos-Nino, MJ Pellegrino, ML Graves, MM Vleugel, MR Young, MR Young, MW Mayo, N Kalra, N Wang, NH Heintz, NR Bhat, NV Shirsat, O Kustikova, O Mariani, P Adiseshaiah, P Angel, P Angel, P Angel, P Lopez-Bergami, P Papassava, Pablo Lopez-Bergami, PK Vogt, Q Ma, Q Shen, R Chiu, R Eferl, R Eferl, R Eferl, R Farras, R Firestein, R Johnson, R Suto, R Wisdom, R Zenz, RJ Davis, RP Ryseck, RR Acay, S Abbas, S Gupta, S Huguier, S Katiyar, S Knippen, S Langer, S Leppa, S Linardopoulos, S Mahner, S Mathas, S Morton, SA Vlahopoulos, SE Adunyah, SE Rutberg, SK Agarwal, SK Manna, SP Jin, SY Chen, SY Chen, SY Fuchs, SY Fuchs, SY Fuchs, T Akimoto, T Deng, T Hai, T Jenuwein, T Kallunki, T Maekawa, T Maekawa, T Maekawa, T Nakamura, T Shiratsuchi, T Suzuki, T Tanos, T Yamasaki, TD Halazonetis, TK Kerppola, TN Lively, TV Pospelova, TW Hai, U Fried, UR Rapp, V Ramirez-Carrozzi, V Zoumpourlis, W Breitwieser, W Jochum, W Jochum, W Lee, W Li, W Wei, W Wei, W Zhang, WH Landschulz, X Deng, X Jin, X Mao, X Ouyang, XY Li, Y Chinenov, Y Maki, Y Shimizu, Y Wo, Y Zhang, Y-N Wang, YM Janssen, Z Ronai, Ze'ev Ronai   +228 more
core   +1 more source

Targeting WEE1 in ARID1A/TP53 Concurrent Mutant Colorectal Cancer by Exploiting R‐Loop Accumulation and DNA Repair Deficiencies

Advanced Science, EarlyView.
ARID1A, a SWI/SNF complex component, is frequently mutated in colorectal cancer (CRC). CRC with ARID1A/TP53 concurrent mutations shows marked sensitivity to WEE1 inhibition. ARID1A loss induces R‐loop‐mediated replication stress, impairs ATF3 transcription, and amplifies WEE1i‐induced DNA damage, suggesting a promising therapeutic vulnerability ...
Chi Zhang, Yanjing Zhu, Luoyan Ai, Jingyuan Wang, Shan Yu, Yichen Wang, Xiaojing Xu, Mengling Liu, Yiyi Yu, Mengxuan Zhu, Yutong Liu, Zhenghang Xu, Haojie Zhou, Huishan Li, Qihong Huang, Qing Liu, Ke Peng, Tianshu Liu   +17 more
wiley   +1 more source

Genome-wide identification of FoxO-dependent gene networks in skeletal muscle during C26 cancer cachexia [PDF]

, 2014
BACKGROUND: Evidence from cachectic cancer patients and animal models of cancer cachexia supports the involvement of Forkhead box O (FoxO) transcription factors in driving cancer-induced skeletal muscle wasting. However, the genome-wide gene networks and
Beharry, Adam W., Ferreira, Leonardo F., Judge, Andrew R., Judge, Sarah M., Kandarian, Susan C., Roberts, Brandon M., Wu, Chia-Ling   +6 more
core   +1 more source

The Potential of Phytochemicals to Overcome Multidrug Resistance in Metastatic Melanoma

Chemistry &Biodiversity, EarlyView.
ABSTRACT Metastatic melanoma is the most lethal form of skin cancer, accounting for most skin cancer‐related deaths. Immunotherapies and targeted therapies have improved overall and progression‐free survival rates in metastatic melanoma patients. The effectiveness of these therapies decreases due to multidrug resistance (MDR).
Jacqueline Maphutha, Danielle Twilley, Mona Dawood, Thomas Efferth, Namrita Lall   +4 more
wiley   +1 more source

Natural Products Targeting the EGFR/HER2 Axis in Tumorigenesis: Interpretation of Molecular Mechanisms and Recent Insights Into Synergistic Strategies for Cancer Therapy

Food Frontiers, EarlyView.
Schematic overview illustrating the anticancer mechanisms of selected natural products (resveratrol, quercetin, berberine) targeting EGFR and HER2 signaling pathways in tumor cells. These compounds inhibit receptor activation and downstream oncogenic cascades, including PI3K/Akt/mTOR, MAPK/ERK, and STAT3 pathways.
Iman Ramli, Anna Maria Posadino, Roberta Giordo, Antonio Barberis, Ylenia Spissu, Redouane Lemoui, William N. Setzer, Javad Sharifi‐Rad, Gianfranco Pintus   +8 more
wiley   +1 more source

Transgenic models of skin diseases [PDF]

, 1993
Background: Transgenic animals have greatly enhanced our understanding of the contribution of various structural and regulatory components to epidermal biology. The expression of mutant versions of these components in the epidermis of transgenic mice has
Bickenbach, Jackie R., Dominey, Andrea M., Greenhalgh, David A., Roop, Dennis R., Rothnagel, Joseph A., Sellheyer, Klaus, Wang, Xiao-Jing   +6 more
core   +1 more source

Intrathecal Amylin and Salmon Calcitonin Affect Formalin Induced c-Fos Expression in the Spinal Cord of Rats

Iranian Journal of Medical Sciences, 2014
Background:Amylin and Salmon Calcitonin belong to the calcitonin family of peptides and have high affinity binding sites in the rat spinal cord. The aim of this study was to characterize receptors for Amylin and Salmon Calcitonin functionally in the ...
Zahra Khoshdel, Mohammad Ali Takhshid, Ali Akbar Owji   +2 more
doaj