Results 51 to 60 of about 34,702 (148)

Synovial fibroblasts: key players in rheumatoid arthritis [PDF]

, 2017
Rheumatoid arthritis (RA) is a chronic autoimmune-disease of unknown origin that primarily affects the joints and ultimately leads to their destruction. The involvement of immune cells is a general hallmark of autoimmune-related disorders. In this regard,
Distler, O., Gay, R. E., Gay, S., Huber, L. C., Pap, T., Tarner, I.   +5 more
core  

Network modelling reveals the mechanism underlying colitis-associated colon cancer and identifies novel combinatorial anti-cancer targets [PDF]

, 2015
The connection between inflammation and tumourigenesis has been well established. However, the detailed molecular mechanism underlying inflammation-associated tumourigenesis remains unknown because this process involves a complex interplay between immune
Chen, Limin, Geng, Meiyu, Huang, Ming, Jiang, Hualiang, Liang, Zhongjie, Liu, Hong, Lu, Junyan, Luo, Cheng, Shen, Bairong, Spiegel, Sarah, Zeng, Hanlin, Zhang, Hao, Zhang, Liyi   +12 more
core   +2 more sources

Targeting WEE1 in ARID1A/TP53 Concurrent Mutant Colorectal Cancer by Exploiting R‐Loop Accumulation and DNA Repair Deficiencies

Advanced Science, Volume 13, Issue 9, 13 February 2026.
ARID1A, a SWI/SNF complex component, is frequently mutated in colorectal cancer (CRC). CRC with ARID1A/TP53 concurrent mutations shows marked sensitivity to WEE1 inhibition. ARID1A loss induces R‐loop‐mediated replication stress, impairs ATF3 transcription, and amplifies WEE1i‐induced DNA damage, suggesting a promising therapeutic vulnerability ...
Chi Zhang, Yanjing Zhu, Luoyan Ai, Jingyuan Wang, Shan Yu, Yichen Wang, Xiaojing Xu, Mengling Liu, Yiyi Yu, Mengxuan Zhu, Yutong Liu, Zhenghang Xu, Haojie Zhou, Huishan Li, Qihong Huang, Qing Liu, Ke Peng, Tianshu Liu   +17 more
wiley   +1 more source

Suppression of cell cycle progression by Jun dimerization protein (JDP2) involves down-regulation of cyclin A2 [PDF]

, 2009
We report here a novel role for Jun dimerization protein-2 (JDP2) as a regulator of the progression of normal cells through the cell cycle. To determine the role of JDP2 in vivo, we generated Jdp2 knock-out (Jdp2KO) mice by targeting exon 1 to disrupt ...
Atsushi Yoshiki, Hitomi Hasegawa, Jianzhi Pan, Kazunari K. Yokoyama, Koji Nakade, Naoto Yamaguchi, Satoko Masuzaki, Takehide Murata, Yu-Chang Huang, Yuichi Obata   +9 more
core   +1 more source

Exosome-mediated transfer of miR-222 is sufficient to increase tumor malignancy in melanoma [PDF]

, 2016
BACKGROUND: Growing evidence is showing that metastatic cell populations are able to transfer their characteristics to less malignant cells. Exosomes (EXOs) are membrane vesicles of endocytic origin able to convey their cargo of mRNAs, microRNAs (miRs),
Bellenghi, Maria, Carè, Alessandra, Coscia, Carolina, Errico, Maria Cristina, Felicetti, Federica, Feo, Alessandra De, Pagani, Elena, Pasquini, Luca, Pedini, Francesca, Puglisi, Rossella   +9 more
core   +5 more sources

Anticancer Molecular Mechanisms of Curcuminoids: An Updated Review of Clinical Trials

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Curcuminoids remain one of the most studied dietary polyphenols as a cancer prevention and treatment agent. Inflammation and tumor progression are related to the NF‐κB signaling pathway, which is also suppressed by curcuminoids. Curcuminoids prevent the activation of a variety of signaling pathways, including the MAPK, PI3K/Akt, and NF‐kB pathways ...
Ushna Momal, Muhammad Shahbaz, Asfa Perween, Muhammad Hammad ul Hassan, Hammad Naeem, Zubda Shahid, Muzzamal Hussain, Muhammad Imran, Suliman A. Alsagaby, Waleed Al Abdulmonem, Mohamed A. Abdelgawad, Mohammed M. Ghoneim, Tadesse FentaYehuala, Samy Selim, Ehab M. Mostafa   +14 more
wiley   +1 more source

Multi‐Omics Revealed the Effects of Intrauterine Hyperglycemia Exposure on the Development of Skeletal Muscle in Offspring

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Background Gestational diabetes mellitus (GDM), a common pregnancy complication characterized by maternal hyperglycemia, negatively impacts offspring health. Skeletal muscle, a critical tissue for glucose and lipid metabolism, is especially vulnerable to prenatal environmental insults.
Rui Liu, Junsen She, Xinyuan Li, Yishang Yan, Jiaying Mo, Jianzhong Sheng, Hongbo Yang, Hefeng Huang   +7 more
wiley   +1 more source

The promoter regions of intellectual disability-associated genes are uniquely enriched in LTR sequences of the MEr41 primate-specific endogenous retrovirus: An evolutionary connection between immunity and cognition [PDF]

, 2019
The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fgene.2019.00321/full#supplementary-materialSocial behavior and neuronal connectivity in rodents have been shown to be shaped by the ...
Benítez Burraco, Antonio, Nataf, Serge, Uriagereka, Juan   +2 more
core   +6 more sources

Inflammation and Cancer: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Chronic inflammation fuels tumorigenesis via “internal drivers” and “external attractions.” Targeting these core mechanisms with combined therapies/novel deliveries enables precise, potent anti‐inflammatory–antitumor treatment. ABSTRACT Inflammation is a core pathological factor regulating tumor initiation, progression, and therapeutic resistance, and ...
Xiaodie Liu, Ziyuan Wang, Huirong Zhu, Yicun Han, Qing Ji   +4 more
wiley   +1 more source

Chrysin Exhibits Bone‐Protective Effects Through Osteoclastogenesis Inhibition: In Vitro and In Vivo Evaluation in RAW 264.7 Murine Macrophages and Sprague–Dawley Rats

Molecular Nutrition &Food Research, Volume 70, Issue 3, 13 February 2026.
The effects of chrysin, a plant‐derived compound, were investigated on osteoclast formation in cell culture and bone health parameters in Sprague–Dawley rats. Chrysin was shown to disrupt key osteoclast signaling pathways and inhibit osteoclast formation. Furthermore, chrysin moderately improved bone health parameters in the rats.
Caitlin Mason, Trevor T. Nyakudya, Abe E. Kasonga   +2 more
wiley   +1 more source