Mechanical Signaling: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets
MedComm, Volume 6, Issue 12, December 2025.In this review, we summarize cell–ECM interactions and delve into the complex mechanotransduction. We introduce advanced research methods and emerging clinical tools used to study cellular mechanical phenotypes, mechanotransduction, and disease progression. Additionally, we analyze the role of mechanical biomarkers in the development and progression of
Yicen Long +5 more
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MedComm, Volume 6, Issue 12, December 2025.Alternative splicing (AS) expands proteomic diversity and functional complexity in eukaryotes, regulated by spliceosomal components, RNA elements, and epigenetic modifications. Dysregulated AS contributes to diseases, including cancer, neurodegenerative disorders, and cardiovascular conditions, among others. Therapeutic interventions, such as antisense
Zhi‐Min Zhu +5 more
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The promoter regions of intellectual disability-associated genes are uniquely enriched in LTR sequences of the MEr41 primate-specific endogenous retrovirus: An evolutionary connection between immunity and cognition [PDF]
, 2019 The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fgene.2019.00321/full#supplementary-materialSocial behavior and neuronal connectivity in rodents have been shown to be shaped by the ...
Benítez Burraco, Antonio +2 more
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Asia-Pacific Journal of Clinical Oncology, Volume 21, Issue 6, Page 660-671, December 2025.ABSTRACT Background Globally, gastric cancer (GC) ranks as the fourth most deadly and fifth most prevalent kind of cancer. Appropriate treatment methods, precise etiology, and molecular processes of GC are still unclear. Methods In silico and quantitative real‐time reverse transcription polymerase chain reaction (qRT‐PCR)‐based expression of miRNA‐27b ...
Yang Dehuo, Wang Ying, Cao Lin
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European Journal of Oral Sciences, Volume 133, Issue 6, December 2025.Abstract Rheumatoid arthritis is a chronic autoimmune disease that can affect the temporomandibular joint (TMJ) and cause pain. Methotrexate is widely used to control disease progression, but its effects on pain mechanisms are not fully understood. This study evaluated the antinociceptive effects of methotrexate on pain behavior, Wnt/β‐catenin pathway ...
Ana Carolina de Figueiredo Costa +6 more
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Protein kinase C regulates proliferation of mast cells and the expression of the mRNAs of fos and jun proto-oncogenes during activation by IgE-Ag or calcium ionophore A23187 [PDF]
, 1991 D Baranes, E Razin
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Evaluation of in vitro macrophage differentiation during space flight [PDF]
, 2012 We differentiated mouse bone marrow cells in the presence of recombinant macrophage colony stimulating (rM-CSF) factor for 14 days during the flight of space shuttle Space Transportation System (STS)-126.
Chapes, Stephen K. +2 more
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Journal of Cellular and Molecular Medicine, Volume 29, Issue 23, December 2025.ABSTRACT The competing endogenous RNA hypothesis offers new insights into tumour progression, yet its role in posttreatment nasopharyngeal carcinoma relapse remains unclear. This study constructed ceRNA networks to identify molecular markers associated with NPC relapse.
Qihong Liu +9 more
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Activation of the Erk8 Mitogen-activated Protein (MAP) Kinase by RET/PTC3, a Constitutively Active Form of the RET Proto-oncogene [PDF]
, 2006 Mitogen-activated protein (MAP) kinases have a central role in several biological functions, including cell adhesion and spreading, chemotaxis, cell cycle progression, differentiation, and apoptosis.
Acunzo, Mario +7 more
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The androgen receptor and signal-transduction pathways in hormone-refractory prostate cancer. Part 2: androgen-receptor cofactors and bypass pathways [PDF]
, 2005 Prostate cancer is the second leading cause of cancer related deaths in men from the western world. Treatment of prostate cancer has relied on androgen deprivation therapy for the past 50 years.
Bakin RE +9 more
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