Results 61 to 70 of about 23,181 (145)

Protein token: a dynamic unit in protein interactions [PDF]

open access: yesarXiv, 2018
In this study, we introduced a new unit, named "protein token", as a dynamic protein structural unit for protein-protein interactions. Unlike the conventional structural units, protein token is not based on the sequential or spatial arrangement of residues, but comprises remote residues involved in cooperative conformational changes during protein ...
arxiv  

Reversing Microglial Polarisation by High Intensity Interval Training: A Novel Approach to Mitigate Inflammatory Responses in Osteoarthritis via Jak2/Stat3 Pathway

open access: yesImmunology, Volume 175, Issue 2, Page 240-250, June 2025.
This study demonstrates that high‐intensity interval training (HIIT) effectively alleviates OA‐induced inflammation by promoting M1 to M2 microglial polarisation via the Jak2/Stat3 pathway. HIIT increases pain thresholds and down‐regulates the expression of pro‐inflammatory factors such as Tmem119, SP, Glu, c‐Fos, and IL‐6 in an OA rat model.
Xinwei Wang   +5 more
wiley   +1 more source

Differential gene expression in the recovery from ischemic renal injury [PDF]

open access: yes, 1991
Differential gene expression in the recovery from ischemic renal injury. Recovery from renal ischemia requires regeneration of damaged tubular epithelium. Previous studies have examined the expression of proto-oncogenes and growth factors after ischemia,
Paller, Mark S., Rosenberg, Mark E.
core   +1 more source

Refining the Protein-Protein Interactome using Gene Expression Data [PDF]

open access: yesarXiv, 2010
Proteins interact with other proteins within biological pathways, forming connected subgraphs in the protein-protein interactome (PPI). Proteins are often involved in multiple biological pathways which complicates interpretation of interactions between proteins.
arxiv  

The Encapsulation Strategies for Targeted Delivery of Probiotics in Preventing and Treating Colorectal Cancer: A Review

open access: yesAdvanced Science, Volume 12, Issue 18, May 15, 2025.
This work summarizes the efficacy and mechanisms of probiotics in CRC treatment, providing a comprehensive overview of various encapsulation methods such as microcapsules, hydrogels, single‐cell nanocoatings, and nanofibers for targeted probiotic delivery to inflammatory sites, with particular emphasis on the potential advantages of emerging single ...
Hao Zhong   +5 more
wiley   +1 more source

Advances in the Study of Metabolic Reprogramming in Gastric Cancer

open access: yesCancer Medicine, Volume 14, Issue 10, May 2025.
ABSTRACT Background Gastric cancer is one of the most prevalent malignancies of the digestive system and is associated with a poor prognosis, particularly in advanced metastatic stages, where the 5‐year survival rate is significantly low. Methods Recent research has demonstrated that metabolic reprogramming—including alterations in glucose, lipid, and ...
Yu Rong, Yuanyin Teng, Xiaoying Zhou
wiley   +1 more source

Global protein function prediction in protein-protein interaction networks [PDF]

open access: yesNature Biotech. 21, 697-700 (2003), 2003
The determination of protein functions is one of the most challenging problems of the post-genomic era. The sequencing of entire genomes and the possibility to access gene's co-expression patterns has moved the attention from the study of single proteins or small complexes to that of the entire proteome. In this context, the search for reliable methods
arxiv  

Coexisting Lung Cancer and Pulmonary Tuberculosis: A Comprehensive Review From Incidence to Management

open access: yesCancer Reports, Volume 8, Issue 5, May 2025.
ABSTRACT Background Globally, infections account for 10% of new cancer cases, and cancer can compromise the immune system, increasing the risk of infections. With advances in cancer treatment, widespread use of immunotherapy, and prolonged survival of cancer patients, the coexistence of tuberculosis (TB) and cancer is becoming increasingly common in ...
Wendi Zhou   +7 more
wiley   +1 more source

Translational Regulation of the C-Jun Proto-Oncogene [PDF]

open access: yes, 1994
The v-jun oncogene was originally isolated from the ASV17 virus in 1987. Ever since its isolation, extensive work has been done to understand the role of the v-jun oncogene in cell transformation.
Sehgal, Anil
core   +1 more source

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