Results 1 to 10 of about 75,334 (151)

Helicobacter pylori Activates Mitogen-activated Protein Kinase Cascades and Induces Expression of the Proto-oncogenes c-fos and c-jun [PDF]

Journal of Biological Chemistry, 2000
Helicobacter pylori is an etiological agent in the development of mucosa-associated lymphoid tissue lymphoma and gastric adenocarcinoma. Patients infected with H. pylori carry a 3-6-fold increased risk of developing cancer compared with uninfected individuals. H.
Meyer-ter-Vehn, Tobias, Covacci, Antonello, Kist, Manfred, Pahl, Heike-L.   +3 more
openaire   +5 more sources

Role of protein kinase C and cyclic adenosine monophosphate in the regulation of tissue-type plasminogen activator, plasminogen activator inhibitor-1, and platelet-derived growth factor mRNA levels in human endothelial cells. Possible involvement of proto-oncogenes c-jun and c-fos. [PDF]

Arteriosclerosis and Thrombosis: A Journal of Vascular Biology, 1991
Activation of protein kinase C leads to a strong induction of tissue-type plasminogen activator (t-PA) expression in endothelial cells. Using endothelial cells from human umbilical vein (HUVECs) and human aorta (HAECs), we have studied this regulation of t-PA and its inhibitor, plasminogen activator inhibitor-1 (PAI-1), at the mRNA level and have ...
Kooistra, T., Bosma, P.J., Toet, K., Cohen, L.H., Griffioen, M., Berg, E. van den, Clercq, L. le, Hinsbergh, V.W.M. van   +7 more
openaire   +4 more sources

Epidermal Growth Factor Stimulation of Stromelysin mRNA in Rat Fibroblasts Requires Induction of Proto-Oncogenes c-fos and c-jun and Activation of Protein Kinase C [PDF]

Molecular and Cellular Biology, 1990
Stromelysin (transin) is a secreted metalloprotease that is transcriptionally induced by a variety of growth factors and oncogenes. We examined the necessity of specific secondary (protein kinase C) and tertiary (c-fos and c-jun protein products) messengers in the transactivation of stromelysin gene expression by epidermal growth factor (EGF).
S E, McDonnell, L D, Kerr, L M, Matrisian   +2 more
  +5 more sources

Hexachlorobenzene-Induced Early Changes in Ornithine Decarboxylase and Protein Tyrosine Kinase Activities, Polyamines and c-Myc, c-Fos and c-Jun Proto-Oncogenes in Rat Liver [PDF]

Toxicological Sciences, 2003
El hexaclorobenceno (HCB) es un compuesto químico lipófilo que se distribuye ampliamente en el medio ambiente. Se sabe que el HCB causa tumores hepáticos en animales de experimentación. En el presente estudio se investigó el efecto in vivo del tratamiento con HCB sobre las actividades de la ornitina descarboxilasa (ODC) y la proteína tirosina quinasa ...
Andrea S, Randi, Susana, Hernandez, Laura, Alvarez, Marcela, Sanchez, Marta, Schwarcz, Diana L, Kleiman d Pisarev   +5 more
openaire   +3 more sources

Pronounced activation of protein kinase C, ornithine decarboxylase and c-jun proto-oncogene by paraquat-generated active oxygen species in WI-38 human lung cells

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1995
Paraquat (methyl viologen, PQ) is a widely used herbicide that produces oxygen-derived free radicals and severely injures human lungs. In this study we examined the effects of PQ on the protein kinase C (PKC), ornithine decarboxylase (ODC) and c-jun oncogene expression in WI-38 human lung cells.
Kuo, Min-Liang, Lee, Kuen-Chen, Lin, Jen-Kun, Huang, Tze-Sing   +3 more
openaire   +3 more sources

Persistent human papillomavirus infection in the etiology of cervical carcinoma: The role of immunological, genetic, viral and cellular factors [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2014
The aim of this paper was to present the role of human papillomavirus (HPV) in cervical carcinogenesis from several aspects. By explaining the HPV virus lifecycle and structure, its effect on cervical cell cycle and subversion of immune response
Živadinović Radomir, Petrić Aleksandra, Lilić Goran, Lilić Vekoslav, Đorđević Biljana   +4 more
doaj   +1 more source

Functional Role and Therapeutic Potential of the Pim-1 Kinase in Colon Carcinoma

Neoplasia: An International Journal for Oncology Research, 2013
PURPOSE: The provirus integration site for Moloney murine leukemia virus 1 (Pim-1) kinase is overexpressed in various tumors and has been linked to poor prognosis.
Ulrike Weirauch, Nadine Beckmann, Maren Thomas, Arnold Grünweller, Kilian Huber, Franz Bracher, Roland K. Hartmann, Achim Aigner   +7 more
doaj   +3 more sources

A Systems Biology Approach to Reveal Putative Host-derived Biomarkers of Periodontitis by Network Topology Characterization of MMP-REDOX/NO and Apoptosis Integrated Pathways

Frontiers in Cellular and Infection Microbiology, 2016
Periodontitis, a formidable global health burden, is a common chronic disease that destroys tooth-supporting tissues. Biomarkers of the early phase of this progressive disease are of utmost importance for global health. In this context, saliva represents
Fares eZeidán-Chuliá, Fares eZeidán-Chuliá, Mervi eGürsoy, Ben-Hur eNeves de Oliveira, Vural eÖzdemir, Vural eÖzdemir, Eija eKönönen, Eija eKönönen, Ulvi Kahraman Gürsoy   +8 more
doaj   +1 more source

Protein kinase C regulates proliferation of mast cells and the expression of the mRNAs of fos and jun proto-oncogenes during activation by IgE-Ag or calcium ionophore A23187 [PDF]

, 1991
D Baranes, E Razin
openalex   +3 more sources

Study on the correlation between Interleukin 4 and febrile seizures. [PDF]

Cytojournal
Xiang X, Wang S, Tang C, Jin H, Lei L, Mao G, Huang X, Huang B.   +7 more
europepmc   +1 more source