Results 141 to 150 of about 75,728 (168)

Human Proto-Oncogene c- jun Encodes a DNA Binding Protein with Structural and Functional Properties of Transcription Factor AP-1

Science, 1987
Nuclear oncogene products have the potential to induce alterations in gene regulation leading to the genesis of cancer. The biochemical mechanisms by which nuclear oncoproteins act remain unknown. Recently, an oncogene, v- jun , was found to share homology with the DNA binding domain of a yeast transcription factor,
D, Bohmann, T J, Bos, A, Admon, T, Nishimura, P K, Vogt, R, Tjian   +5 more
openaire   +2 more sources

Correlation between lack of bone Gla protein mRNA expression in rat transplantable osteosarcomas and expression of both c‐fos and c‐jun proto‐oncogenes

Molecular Carcinogenesis, 1993
AbstractAlkaline phosphatase (AP) activity and expression of bone Gla protein (BGP), c‐fos, and c‐jun were compared in two transplantable osteosarcomas with high potentials for metastasis to the lung. The original spontaneous osteosarcoma (SOS) gradually became histologically undifferentiated, losing its osteogenic activity during serial transfer ...
Kanya Honoki, Yoshiko Dohi, Shiro Tabata, Yoshio Mii, Yoshizumi Miyauchi, Masahiro Tsutsumi, Toshifumi Tsujiuchi, Toru Morishita, Syuichi Miura, Tadashige Moriyama, Susumu Tamai, Yoichi Konishi   +11 more
openaire   +2 more sources

Selective activation of the proto-oncogene c-jun promoter by the transforming protein v-Rel.

Oncogene, 1996
The transcription factor v-Rel is a transforming protein of the reticuloendotheliosis virus. We found that v-Rel activates the promoter of the proto-oncogene c-jun. Two elements in the c-jun promoter were required for the activation by v-Rel. One was a kB-site (v-Rel binding site), and the other was a c-jun promoter region between -52 and +148 (c-jun ...
M, Fujii, T, Minamino, M, Nomura, K I, Miyamoto, J, Tanaka, M, Seiki   +5 more
openaire   +1 more source

Inhibition of protein kinase C prevents asbestos-induced c-fos and c-jun proto-oncogene expression in mesothelial cells.

Cancer research, 1997
Asbestos and the phorbol ester tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), increase c-fos and c-jun mRNA levels and AP-1 DNA binding activity in rat pleural mesothelial (RPM) cells, a target cell of asbestos-induced mesotheliomas (N. H. Heintz et al., Proc. Natl. Acad. Sci. USA, 90: 3299-3303, 1993).
H, Fung, T R, Quinlan, Y M, Janssen, C R, Timblin, J P, Marsh, N H, Heintz, D J, Taatjes, P, Vacek, S, Jaken, B T, Mossman   +9 more
openaire   +1 more source

[Effects of acrylamide on the protein expressions of c-fos and c-jun proto-oncogenes in cell L-02].

Wei sheng yan jiu = Journal of hygiene research, 2012
To investigate the cell apoptosis and expressions of c-fos and c-jun proteins induced by acrylamide (AA) in L-02 human liver embryo cell.The cell survival rate, cell apoptosis and protein expressions of c-fos and c-jun were measured respectively after L-02 cell were exposed to different final concentration of AA (low: 0.01, 0.1 mmol/l; middle: 0.1, 0.5,
Rui, Wang, Jianjun, Liu, Cai, Huang, Qifeng, Qian, Qing, Li, Xiaoli, Liu   +5 more
openaire   +1 more source

[Rules of protein expression of proto-oncogene (c-Fos/c-Jun) in different brain areas and nucleus of psychological stressed mice and the regulatory effect of modified Xiaoyao Pill].

Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 2008
To study the rules of protein expression of proto-oncogene (c-Fos/c-Jun) in different brain areas and nucleus of psychological stressed mice and the regulatory effect of modified Xiaoyao Pill (SXP).The mouse psychological stress model was established by electrical stimulation; SXP was administrated at the dose of 2 mg/g; the protein expression of c-Fos
Zhen-yu, Wu, Yun, Zhang, Jian, Xiao
openaire   +1 more source

Silica-induced activation of c-Jun-NH2-terminal amino kinases, protracted expression of the activator protein-1 proto-oncogene, fra-1, and S-phase alterations are mediated via oxidative stress.

Cancer research, 2001
Crystalline silica has been classified as a group 1 human carcinogen in the lung. However, its mechanisms of action on pulmonary epithelial cells which give rise to lung cancers are unclear. Using a nontransformed alveolar type II epithelial cell line (C10), we show that alpha-quartz silica causes persistent dose-related increases in phosphorylation of
A, Shukla, C R, Timblin, A K, Hubbard, J, Bravman, B T, Mossman   +4 more
openaire   +1 more source

Influence of ovulatory LH surge on the expression of c-fos and c-jun proto-oncogene protein products in rat ovary

Journal of the Society for Gynecologic Investigation, 1995
openaire   +1 more source

The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1

Cell, 1988
Michael Karin
exaly  

Induction of proto-oncogene JUN/AP-1 by serum and TPA

Nature, 1988
Paolo Sassone-Corsi
exaly