Results 91 to 100 of about 5,394 (238)

Data from FRA-1 Proto-Oncogene Induces Lung Epithelial Cell Invasion and Anchorage-Independent Growth <i>In vitro</i>, but Is Insufficient to Promote Tumor Growth <i>In vivo</i>

, 2023
Pavan P. Adiseshaiah, Daniel J. Lindner, Dhananjaya V. Kalvakolanu, Sekhar P. Reddy   +3 more
openalex   +1 more source

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

FEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source

Biología del cáncer

Correo Científico Médico, 2019
El cáncer constituye un problema de salud con gran impacto humano y económico. La mortalidad por cáncer ha aumentado sostenidamente en los últimos 25 años a nivel mundial.
Alejandro Bermúdez Garcell, Nilvia Bienvenida Serrano Gámez, Rolando Teruel Ginés, María de los Ángeles Leyva Montero, Anthony Alfonso Naranjo Coronel   +4 more
doaj   +2 more sources

Proliferation of human myeloid leukemia cell line associated with the tyrosine-phosphorylation and activation of the proto-oncogene c-kit product [PDF]

, 1991
A Kuriu, Hirokazu Ikeda, Yuzuru Kanakura, JD Griffin, Brian Druker, H Yagura, H Kitayama, Jun Ishikawa, Takafumi Nishiura, Y Kanayama   +9 more
openalex   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Expression of the c-myc Proto-oncogene Is Essential for HIV-1 Infection in Activated T Cells [PDF]

, 1999
Yu Sun, Edward A. Clark
openalex   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

Germline Variants in Proto-Oncogenes and Tumor Suppressor Genes in Women with Cervical Cancer

Biomedicines
Background/Objectives: Cervical cancer (CC) remains a significant global health challenge, characterized by genetic heterogeneity and a complex molecular landscape, both of which contribute to its pathogenesis.
Ksenia Lenkova, Rita Khusainova, Raushaniya Minyazeva, Aliya Zaripova, Irina Gilyazova, Natalia Mokrysheva, Ildar Minniakhmetov   +6 more
doaj   +1 more source

Structure, chromosome location, and expression of the mouse zinc finger gene Krox-20: multiple gene products and coregulation with the proto-oncogene c-fos.

, 1989
Philippe Chavrier, U Janssen-Timmen, Marie‐Geneviève Mattéi, Marino Zerial, R Bravo, Patrick Charnay   +5 more
openalex   +2 more sources