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Cancer: From a Genetic Disorder to a Systemic Disease. [PDF]

Adv Sci (Weinh)
Wong AH, Hu Y.
europepmc   +1 more source

The role of inflammation in the immune evasion of KRas. [PDF]

Front Immunol
Homan EJ, Bremel RD.
europepmc   +1 more source

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Proto‐Oncogenes in Development and Cancer

American Journal of Reproductive Immunology, 1991
ABSTRACT: Although analogies are often made comparing development to cancer, there is of course a major difference. Normal development requires complex patterns of rigidly controlled cell proliferation and differentiation. In contrast, cancer represents the pathological condition that results when normal cell growth patterns are uncoupled from their ...
Geoffrey M Cooper
exaly   +4 more sources

Proto-oncogenes and embryonic development

Biochimie, 1988
The role of proto-oncogenes in embryonic development was investigated using one of the most characterized vertebrates, the amphibian Xenopus laevis. Genes which belong to the major proto-oncogene families have been detected in Xenopus genome. The developmental control of the myc gene was assayed using a characterized Xenopus myc probe and specific ...
Sophie Vriz, Michael V Taylor, Yannick Andéol   +2 more
exaly   +3 more sources

Proto-oncogenes and differentiation

Trends in Biochemical Sciences, 1986
Abstract Since their discovery, the cellular homologues of retroviral oncogenes have been presumed to play a role in growth control, mainly because of their potential to induce uncontrolled cellular proliferation. This notion is now strongly supported by evidence that the products of several proto-oncogenes are either growth factors or growth factor ...
R. Müller
openaire   +2 more sources

Tetraphenylethene Derivatives Modulate the RNA Hairpin‐G‐Quadruplex Conformational Equilibria in Proto‐oncogenes**

ChemBioChem, 2022
RNA G-quadruplexes (GQs) sequence in 5\u27 UTRs of certain proto-oncogenes colocalize with hairpin (Hp) forming sequence resulting in intramolecular Hp-GQ conformational equilibria which is suggested to regulate cancer development and progression.
Dinesh N Nadimetla, Sheshanath V Bhosale, Ambadas B Rode   +2 more
exaly   +2 more sources

Amplification of the proto-oncogenes int-2, c-erbB-2 and c-myc in human breast cancer

Clinica Chimica Acta, 1989
Carleton T Garrett, R Callahan
exaly   +2 more sources

In vivo study on the effects of microcystin extracts on the expression profiles of proto-oncogenes (c-fos, c-jun and c-myc) in liver, kidney and testis of male Wistar rats injected i.v. with toxins

Toxicon, 2009
Guangyu Li, Le Hao, Qian Xiong
exaly   +2 more sources

Oncogenes and proto-oncogenes

Journal of Cellular Physiology, 1983
The discovery that normal cells contain proto-oncogenes--genes that are analogous to known viral oncogenes--may provide a shortcut not only to understanding some of the pathophysiologic mechanisms that must be involved in carcinogenesis but also to dissecting the processes of normal cell growth and of the evolutionarily developed controls on such ...
openaire   +3 more sources