Results 61 to 70 of about 4,711 (225)

From Vesicles to Protocells: The Roles of Amphiphilic Molecules

Life, 2015
It is very challenging to construct protocells from molecular assemblies. An important step in this challenge is the achievement of vesicle dynamics that are relevant to cellular functions, such as membrane trafficking and self-reproduction, using ...
Yuka Sakuma, Masayuki Imai
doaj   +1 more source

Preliminary steps toward artificial protocell computation [PDF]

, 2007
Protocells are hypothesised as a transitional phase in the origin of life, prior to the evolution of fully functional prokaryotic cells. The work reported here is being done in the context of the PACE project, which is investigating the fabrication of ...
Decraene, James, Kelly, Ciarán, McMullin, Barry, Mitchell, George G., O'Brien, Darragh   +4 more
core   +1 more source

Autonomous model protocell division driven by molecular replication [PDF]

, 2017
The coupling of compartmentalisation with molecular replication is thought to be crucial for the emergence of the first evolvable chemical systems. Minimal artificial replicators have been designed based on molecular recognition, inspired by the template
Cronin, L., Eghtesadi, S.A., Liu, T., Points, L.J., Taylor, J.W.   +4 more
core   +1 more source

Growth, Dissolution and Segregation of Genetically Encoded RNA Droplets by Ribozyme Catalysis

Angewandte Chemie, Volume 138, Issue 7, 9 February 2026.
Ribozymes enable sequence‐encoded turnover of RNA droplet material, resulting in transiently active droplets that selectively segregate based on their genotype. This establishes a direct link between genetic information and droplet behavior, marking a step toward programmable, evolvable RNA‐based compartments with life‐like properties.
Franziska Giessler, William Verstraeten, Tobias Abele, Stefan J. Maurer, Luca Monari, Kerstin Göpfrich   +5 more
wiley   +2 more sources

Mode Switching and Collective Behavior in Chemical Oil Droplets

Entropy, 2011
We have characterized several dynamic aspects of a simple chemical system capable of self-movement: An oil droplet in water system. We focused on spontaneous mode switching and collective behavior of droplets as emergent properties of the system ...
Takashi Ikegami, Naoto Horibe, Martin M. Hanczyc   +2 more
doaj   +1 more source

Bioinspired Networks of Communicating Synthetic Protocells

Frontiers in Molecular Biosciences, 2021
The bottom-up synthesis of cell-like entities or protocells from inanimate molecules and materials is one of the grand challenges of our time. In the past decade, researchers in the emerging field of bottom-up synthetic biology have developed different ...
Patrick J. Grimes, Agostino Galanti, Agostino Galanti, Pierangelo Gobbo, Pierangelo Gobbo   +4 more
doaj   +1 more source

Myth and fact in the origins of cellular life on Earth [PDF]

, 2017
Research into the origins of the first protocell is of a multidisciplinary nature. It draws evidence from what we know about the Earth’s early atmosphere and environment, and about the most ancient features of the cell’s structure and composition.
Jowett, P., Rayne, Richard, Tomas, Salvador   +2 more
core   +1 more source

Primitive Membrane Formation, Characteristics and Roles in the Emergent Properties of a Protocell

Entropy, 2011
All contemporary living cells are composed of a collection of self-assembled molecular elements that by themselves are non-living but through the creation of a network exhibit the emergent properties of self-maintenance, self-reproduction, and evolution.
Pierre-Alain Monnard, Sarah Elizabeth Maurer   +1 more
doaj   +1 more source

Protocell design through modular compartmentalization [PDF]

Journal of The Royal Society Interface, 2013
De novo synthetic biological design has the potential to significantly impact upon applications such as energy generation and nanofabrication. Current designs for constructing organisms from component parts are typically limited in scope, as they utilize a cut-and-paste ideology to create simple stepwise engineered protein-signalling pathways.
Miller, David, Booth, Paula J, Seddon, John M, Templer, Richard H, Law, Robert V, Woscholski, Rudiger, Ces, Oscar, Barter, Laura M C   +7 more
openaire   +3 more sources

Synthesis of a π‐Extended Phenazine Diimide Derivative and Characterization of Its Closed‐Shell Reduced States

Chemistry – A European Journal, EarlyView.
In this work, the synthesis and characterization of novel π‐extended phenazine diimides is reported. The derivatives undergo differential reduction to a dihydrophenazine or Meisenheimer form depending on the reaction conditions employed. The outcome of this work highlights the paramount importance of structural design in determining the nature of the ...
Francesco Rigodanza, Beatrice Bartolomei, Ilaria Crea, Paolo Costa, Nicola Demitri, Marcella Bonchio, Maurizio Prato, Jacopo Dosso   +7 more
wiley   +1 more source