Results 51 to 60 of about 57,965 (293)

Optimizing Angiopep‐2 Density on Polymeric Nanoparticles for Enhanced Blood–Brain Barrier Penetration and Glioblastoma Targeting: Insights From In Vitro and In Vivo Experiments

Advanced Functional Materials, EarlyView.
The Angiopep‐2 peptide density on polymeric nanoparticles significantly impacts blood–brain barrier (BBB) penetration. This study explores this nuanced relationship using various in vitro models and in vivo assays, revealing that dynamic models better predict BBB penetration.
Weisen Zhang, Ahmed Refaat, Haoqin Li, Douer Zhu, Ziqiu Tong, Joseph Anthony Nicolazzo, Bo Peng, Hua Bai, Lars Esser, Nicolas Hans Voelcker   +9 more
wiley   +1 more source

Vonoprazan-based triple therapy is non-inferior to susceptibility-guided proton pump inhibitor-based triple therapy for Helicobacter pylori eradication

Annals of Clinical Microbiology and Antimicrobials, 2018
Background All Helicobacter pylori-infected patients are recommended for eradication with an appropriate regimen in each geographic area. The choice of the therapy is somewhat dependent on the antimicrobial susceptibility.
Hiroki Tanabe, Keiichi Yoshino, Katsuyoshi Ando, Yoshiki Nomura, Katsuhisa Ohta, Kiichi Satoh, Eiichiro Ichiishi, Akiei Ishizuka, Takaaki Otake, Yutaka Kohgo, Mikihiro Fujiya, Toshikatsu Okumura   +11 more
doaj   +1 more source

The Frontiers of Aqueous Zinc–Iodine Batteries: A Comprehensive Review on Mechanisms, Optimization, and Industrial Prospects

Advanced Functional Materials, EarlyView.
This review provides an in‐depth understanding of all theoretical reaction mechanisms to date concerning zinc–iodine batteries. It revisits the inherent issues and solutions of zinc–iodine batteries from the perspective of industrial application. By integrating existing examples of energy storage applications, it identifies the challenges faced on the ...
Haokun Wen, Hanyu Wen, Ying Sun, Jiazhuo Li, Changlei Zhuang, Minghui Liu, Hui Li, Hua Fan, Bosi Yin, Siwen Zhang, Tianyi Ma   +10 more
wiley   +1 more source

Drugs in Focus: Proton Pump Inhibitors

Journal of Pediatric Gastroenterology & Nutrition, 2021
ABSTRACTProton pump inhibitors (PPIs) are amongst the most commonly prescribed drugs in infants and children with the last decades witnessing a dramatic rise in their utilization. Although PPIs are clearly effective when used appropriately and have been regarded as safe drugs, there is growing evidence regarding their potential adverse effects ...
Rok Orel, Marc A. Benninga, Nikhil Thapar, Michael Wilschanski, Alexandra Papadopoulou, Ilse Broekaert, Mike Thomson, Carmen Ribes-Koninckx, Frédéric Gottrand   +8 more
openaire   +3 more sources

Machine Learning‐Enabled Polymer Discovery for Enhanced Pulmonary siRNA Delivery

Advanced Functional Materials, EarlyView.
This study provides an efficient approach to train a machine learning model by merging heterogeneous literature data to predict suitable polymers for siRNA delivery. Without the need for extensive laboratory synthesis, the machine learning enabled a virtual screening and successfully predicted a polymer that is validated for effective gene silencing in
Felix Sieber‐Schäfer, Min Jiang, Adrian Kromer, Anny Nguyen, Müge Molbay, Simone Pinto Carneiro, David Jürgens, Gerald Burgstaller, Bastian Popper, Benjamin Winkeljann, Olivia Monika Merkel   +10 more
wiley   +1 more source

Efficacy of Adding Baclofen to Treat Patients with Non-Erosive Reflux Disease Resistant to Treatment

مجله دانشکده پزشکی اصفهان, 2015
Background: Non-erosive reflux disease (NERD) is one of the categories of gastro-esophageal reflux disease defined as the presence of classic reflux symptoms in the absence of esophageal mucosal injury during upper endoscopy.
Mahsa Foroughi, Akbar Arjmandpour, Ahmad Sobhani   +2 more
doaj  

Outcome of Post Esophageal Variceal Band Ligation with Sucralfate and Proton Pump Inhibitor vs. Proton Pump Inhibitor Alone in Cirrhotic Patients

Nepalese Medical Journal, 2019
Introduction: Endoscopic band ligation is the mainstay of treatment in bleeding varices in cirrhosis.  Subsequent bleeding from the band ulcers is a possible complication.
Binod Karki, Ramila Shrestha, Bidhan Nidhi Paudel, Sudhamshu KC, Dibas Khadka, Suresh Thapa, Bibek Kumar Purbey, Sanjit Karki, Pukar Thapa, Amrendra Mandal   +9 more
doaj   +1 more source

Double Cross‐Linked Hydrogel for Intra‐articular Injection as Modality for Macrophages Metabolic Reprogramming and Therapy of Rheumatoid Arthritis

Advanced Functional Materials, EarlyView.
A hydrogel for intra‐articular injection for the treatment of rheumatoid arthritis (RA) is formulated and comprehensively studied. After administration, the hydrogel induces a metabolic reprogramming of immunometabolism of macrophages to trigger fatty acid oxidation subsequently inducing polarization of anti‐inflammatory M2 macrophages. This results in
Yutong Song, Valentin A. Milichko, Ziqiao Ding, Wen Li, Bei Kang, Yunsheng Dou, Sona Krizkova, Zbynek Heger, Nan Li   +8 more
wiley   +1 more source

Transforming Cellulose Into Functional Three‐Dimensional Structures

Advanced Functional Materials, EarlyView.
Cellulose is promising for replacing synthetic polymers due to its excellent mechanical properties and low cost. This review highlights the recent advancements in transforming cellulose into functional 3D structures, including liquid gels and porous materials.
Xia Sun, Hao Sun, Penghui Zhu, Yonggang Wu, Anna Palmer, Feng Jiang   +5 more
wiley   +1 more source

Selective Membrane for Non‐Aqueous Electrochemical Flow Cells

Advanced Functional Materials, EarlyView.
Sulfonated fixed charge functionalization is increased to improve the conductivity of a cation exchange membrane in a non‐aqueous electrochemical cell. Based on ex situ analyses, the material achieved the highest selectivity for this type of system to date.
Charles R. Leroux, Geoffrey M. Geise, Gary M. Koenig Jr   +2 more
wiley   +1 more source