Results 101 to 110 of about 848,265 (305)

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

open access: yesFEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla   +10 more
wiley   +1 more source

Comparative clinical evaluation of atlas and deep-learning-based auto-segmentation of organ structures in liver cancer

open access: yesRadiation Oncology, 2019
Background Accurate and standardized descriptions of organs at risk (OARs) are essential in radiation therapy for treatment planning and evaluation. Traditionally, physicians have contoured patient images manually, which, is time-consuming and subject to
Sang Hee Ahn   +14 more
doaj   +1 more source

Observation of partonic flow in proton—proton and proton—nucleus collisions [PDF]

open access: yesNature Communications
Abstract Quantum Chromodynamics predicts a phase transition from hadronic matter to quark–gluon plasma (QGP) at high temperatures and energy densities, where quarks and gluons (partons) are no longer confined within hadrons. The QGP forms in ultrarelativistic heavy-ion collisions.
null, null   +952 more
openaire   +9 more sources

Comprehensive Characterization of 98 Chinese Cases of Genetic Creutzfeldt‐Jakob Disease With T188K Mutation

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize the demographic, clinical, and laboratory features of the Chinese patients of genetic Creutzfeldt‐Jakob disease with T188K variant (T188K‐gCJD), the most common subtype of genetic prion diseases (gPrDs) in China. Methods In this nationwide retrospective study, data from 98 genetically confirmed T188K‐gCJD patients ...
Chun‐Jie Li   +11 more
wiley   +1 more source

Clinical validation of commercial deep-learning based auto-segmentation models for organs at risk in the head and neck region: a single institution study

open access: yesFrontiers in Oncology
PurposeTo evaluate organ at risk (OAR) auto-segmentation in the head and neck region of computed tomography images using two different commercially available deep-learning-based auto-segmentation (DLAS) tools in a single institutional clinical ...
Casey L. Johnson   +12 more
doaj   +1 more source

Emission of neutron–proton and proton–proton pairs in neutrino scattering

open access: yesPhysics Letters B, 2016
9 pages and 8 ...
Ruiz Simo, I.   +6 more
openaire   +6 more sources

T1 Over Squared Proton Density Ratio to Characterize Multiple Sclerosis Lesions

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Differentiating remyelinated from demyelinated lesions in MS remains challenging without histological confirmation. This study introduces the T1‐to‐PD2 ratio (TPR) imaging approach and evaluates its ability to characterize MS lesions alongside other quantitative MRI (qMRI) metrics. Methods Thirty individuals with MS (mean age: 47.5 ± 
Sarah J. Wright   +10 more
wiley   +1 more source

Impact of additional PRV constraint to Direct OAR robust optimization in IMPT for targets near serial organs at risk

open access: yesRadiation Oncology
Purpose In intensity-modulated proton therapy (IMPT), the benefit of adding planning organ-at-risk volume (PRV)-like nominal constraints to direct robust optimization for serial organs at risk remains uncertain when target-OAR separation is minimal ...
Sham Sundar   +5 more
doaj   +1 more source

Phase I/II trial evaluating concurrent carbon-ion radiotherapy plus chemotherapy for salvage treatment of locally recurrent nasopharyngeal carcinoma

open access: yesChinese Journal of Cancer, 2016
Background After definitive chemoradiotherapy for non-metastatic nasopharyngeal carcinoma (NPC), more than 10% of patients will experience a local recurrence. Salvage treatments present significant challenges for locally recurrent NPC.
Lin Kong   +6 more
doaj   +1 more source

Proton-Proton Scattering at 340 Mev

open access: yesPhysical Review, 1950
Measurements of the proton-proton differential scattering cross section using 340-Mev protons show a cross section approximately constant between 41\ifmmode^\circ\else\textdegree\fi{} and 90\ifmmode^\circ\else\textdegree\fi{} in the center of mass system. Two methods of counting the scattered protons have been used.
Chamberlain, Owen, Wiegand, Clyde
openaire   +4 more sources

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