Results 51 to 60 of about 107,480 (290)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Enhanced performance of nanocomposite membrane developed on sulfonated poly (1, 4-phenylene ether-ether-sulfone) with zeolite imidazole frameworks for fuel cell application

Scientific Reports, 2023
Proton exchange membrane fuel cells (PEMFC) have received a lot of interest and use metal–organic frameworks (MOF)/polymer nanocomposite membranes. Zeolite imidazole framework-90 (ZIF-90) was employed as an addition in the sulfonated poly (1, 4-phenylene
Bita Soleimani, Ali Haghighi Asl, Behnam Khoshandam, Khadijeh Hooshyari   +3 more
doaj   +1 more source

Proton conductivity and luminiscence properties of lanthanide aminotriphosphonates [PDF]

, 2016
Metal phosphonates are multifunctional solids with tunable properties, such as internal H-bond networks, and high chemical and thermal stability [1]. In the present work, we describe the synthesis, structural characterization, luminescent properties ...
Angeli, Giasemi K., Bazaga-García, Montse, Cabeza-Diaz, Aurelio, Choquesillo-Lazarte, Duane, Demadis, Konstantinos D., Hix, Gary B., Losilla, E. R., Olivera-Pastor, Pascual, Papathanasiou, Konstantinos E., Salcedo, Inés R.   +9 more
core  

Novel ETFE based radiation grafted poly(styrene sulfonic acid-co-methacrylonitrile) proton conducting membranes with increased stability [PDF]

, 2009
Styrene radiation grafted ETFE based proton conducting membranes are subject to degradation under fuel cell operating conditions and show a poor stability. Lifetimes exceeding 250 h can only be achieved with crosslinked membranes.
Alkan Gursel, Selmiye, Alkan Gürsel, Selmiye, Ben youcef, Hicham, Gubler, Lorenz, Henkensmeier, Dirk, Scherer, Gunther G., Scherer, Günther G., Wokaun, Alexander   +7 more
core   +2 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Proton-Blocking Anion-Exchange Membranes for Efficient Lithium Hydroxide Recovery by Bipolar Membrane Electrodialysis

Membranes
In bipolar membrane electrodialysis (BPED), proton transport through the anion-exchange membrane (AEM) is a major factor that reduces overall process efficiency.
Ji-Hyeon Lee, Moon-Sung Kang
doaj   +1 more source

Polyvinylimidazole-wrapped Halloysite Nanotubes for High Proton Conductivity in Polymer Electrolyte Membranes

International Journal of Electrochemical Science, 2020
The construction of continuous proton transfer channels within a proton exchange membrane is an important and challenging task for the logical design of proton exchange membranes. Herein, inspired by the mechanism of moisture transport used by plants and
Xiaoyang Liu, Xiang Sun, Hongqian Ren, Mengjie Yang, Mingling Xia, Jinghe Hou, Yi Feng, Huili Ding   +7 more
doaj   +1 more source

Composite membranes for proton exchange membrane fuel cells based on methyl methacrylate-co-maleimide /phosphotungstic acid [PDF]

شیمی کاربردی روز, 2018
Poly(methyl methacrylate-co-nitrophenyl maleimide) (MMA-co-NMI) and poly(methyl‌‌‌‌ methacrylate-co-hydroxyphenyl maleimide)‌‌‌‌‌ (MMA-co-HMI) copolymers were synthesized using free radical polymerization of MMA with a new MI monomer containing phenyl ...
zahra seidzadeh, Fariborz Atabaki, negin Ghaemi, Mohammad Nasiri   +3 more
doaj   +1 more source

On the Cooling of the Neutron Star in Cassiopeia A

, 2011
We demonstrate that the high-quality cooling data observed for the young neutron star in the supernova remnant Cassiopeia A over the past 10 years--as well as all other reliably known temperature data of neutron stars--can be comfortably explained within
C. Schaab, D. Blaschke, D. N. Voskresensky, D. N. Voskresensky, D. N. Voskresensky, F. Weber, H. Grigorian, H. Tananbaum, W. B. Ashworth Jr.   +8 more
core   +1 more source

Network Localization of Fatigue in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Fatigue is among the most common symptoms and one of the main factors determining the quality of life in multiple sclerosis (MS). However, the neurobiological mechanisms underlying fatigue are not fully understood. Here we studied lesion locations and their connections in individuals with MS, aiming to identify brain networks ...
Olli Likitalo, Jaakko Kungshamn, Albert Bellmunt‐Gil, Silvia Tommasin, Abhineet Ojha, Matias Viitala, Juho Aaltonen, Jyrki Lötjönen, Juha Koikkalainen, Pauli Ylikotila, Patrizia Pantano, Merja Soilu‐Hänninen, Juho Joutsa   +12 more
wiley   +1 more source