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Role of proton pumps in tumorigenesis
Biochemistry (Moscow), 2017One of the differences between normal and cancer cells is lower pH of the extracellular space in tumors. Low pH in the extracellular space activates proteases and stimulates tumor invasion and metastasis. Tumor cells display higher level of the HIF1α transcription factor that promotes cell switch from mitochondrial respiration to glycolysis.
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An Overview of Proton Pump Inhibitors
Gastroenterology Nursing, 2003Proton pump inhibitors are the standard of treatment for acid-related disorders. These disorders include gastroesophageal reflux disease and its complications (i.e., erosive esophagitis and Barrett's esophagus), peptic ulcer disease, Zollinger-Ellison syndrome, and idiopathic hypersecretion.
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Proton Pump Inhibitors and Mortality
Gastroenterology, 2023Helge L. Waldum, Reidar Fossmark
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PROTON PUMP INHIBITORS IN INFANTS
Journal of Pediatric Gastroenterology and Nutrition, 2005Thomas P. Iarocci +6 more
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Proton Pump Inhibitors and Risk of Fractures: A Meta-Analysis of 11 International Studies
American Journal of Medicine, 2011Douglas Bauer, Paul A Bain, Elaine W Yu
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Proton pump inhibitors: from CYP2C19 pharmacogenetics to precision medicine
Expert Opinion on Drug Metabolism and Toxicology, 2018Julie Johnson +2 more
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