Results 51 to 60 of about 708,849 (309)

Prognostic Impact of Treatment Modalities, Including Targeted Compartmental Radio‐Immunotherapy, in a Cohort of Neuroblastoma Patients With CNS Metastases at Relapse

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Neuroblastoma (NB) with central nervous system (CNS) metastases is rare at diagnosis, but occurs more often during relapse/progression. Patients with CNS metastases face a dismal prognosis, with no standardized curative treatment available.
Vicente Santa‐Maria Lopez, Anna Felip‐Badia, Marina Caballero‐Bellon, Nazaret Sanchez‐Sierra, Alicia Castañeda, Moira Garraus, Maite Gorostegui, Margarida Simão‐Rafael, Juan Pablo Muñoz, Marta Perez‐Somarriba, Salvador Mañe, Mariana Cecilia Planells, Sara Perez‐Jaume, Jaume Mora   +13 more
wiley   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Cosmic protons [PDF]

Physics Letters B, 2000
The primary proton spectrum in the kinetic energy range 0.2 to 200 GeV was measured by the Alpha Magnetic Spectrometer (AMS) during space shuttle flight STS–91 at an altitude of 380 km. The complete data set combining three shuttle attitudes and including all known systematic effects is ...
Alcaraz, J, Alpat, B, Ambrosi, G, Anderhub, H, Ao, L, Arefiev, A, Azzarello, P, Babucci, E, Baldini, L, Basile, M, Barancourt, D, Barao, F, Barbier, G, Barreira, G, Battiston, R, Becker, R, Becker, U, Bellagamba, L, Béné, P, Berdugo, J, Berges, P, Bertucci, B, Biland, A, Bizzaglia, S, Blasko, S, BOELLA, GIULIANO FILIPPO, Boschini, M, Bourquin, M, Brocco, L, Bruni, G, Buenerd, M, Burger, J, Burger, W, Cai, X, Camps, C, Cannarsa, P, Capell, M, Casadei, D, Casaus, J, Castellini, G, Cecchi, C, Chang, Y, Chen, H, Chen, H, Chen, Z, Chernoplekov, N, Chiueh, T, Chuang, Y, Cindolo, F, Commichau, V, Contin, A, Crespo, P, Cristinziani, M, Cunha, J, Dai, T, Deus, J, Dinu, N, Djambazov, L, D'Antone, I, Dong, Z, Emonet, P, Engelberg, J, Eppling, F, Eronen, T, Esposito, G, Extermann, P, Favier, J, Fiandrini, E, Fisher, P, Fluegge, G, Fouque, N, Galaktionov, Y, GERVASI, MASSIMO, Giusti, P, Grandi, D, Grimm, O, Gu, W, Hangarter, K, Hasan, A, Hermel, V, Hofer, H, Huang, M, Hungerford, W, Ionica, M, Ionica, R, Jongmanns, M, Karlamaa, K, Karpinski, W, Kenney, G, Kenny, J, Kim, W, Klimentov, A, Kossakowski, R, Koutsenko, V, Kraeber, M, Laborie, G, Laitinen, T, Lamanna, G, Laurenti, G, Lebedev, A, Lee, S, Levi, G, Levtchenko, P, Liu, C, Liu, H, Lopes, I, Lu, G, Lu, Y, Lübelsmeyer, K, Luckey, D, Lustermann, W, Maña, C, Margotti, A, Mayet, F, McNeil, R, Meillon, B, Menichelli, M, Mihul, A, Mourao, A, Mujunen, A, Palmonari, F, Papi, A, Park, I, Pauluzzi, M, Pauss, F, Perrin, E, Pesci, A, Pevsner, A, Pimenta, M, Plyaskin, V, Pojidaev, V, Pohl, M, Postolache, V, Produit, N, Rancoita, P, Rapin, D, Raupach, F, Ren, D, Ren, Z, Ribordy, M, Richeux, J, Riihonen, E, Ritakari, J, Roeser, U, Roissin, C, Sagdeev, R, Sartorelli, G, Dratzig, A, Schwering, G, Scolieri, G, Seo, E, Shoutko, V, Shoumilov, E, Siedling, R, Son, D, Song, T, Steuer, M, Sun, G, Suter, H, Tang, X, Ting, S, Ting, S, Tornikoski, M, Torsti, J, Trümper, J, Ulbricht, J, Urpo, S, Usoskin, I, Valtonen, E, Vandenhirtz, J, Velcea, F, Velikhov, E, Verlaat, B, Vetlitsky, I, Vezzu, F, Vialle, J, Viertel, G, Vité, D, Gunten, H, Wicki, S, Wallraff, W, Wang, B, Wang, J, Wang, Y, Wiik, K, Williams, C, Wu, S, Xia, P, Yan, J, Yan, L, Yang, C, Yang, M, Ye, S, Yeh, P, Xu, Z, Zhang, H, Zhang, Z, Zhao, D, Zhu, G, Zhu, W   +199 more
openaire   +5 more sources

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Imaging an optogenetic pH sensor reveals that protons mediate lateral inhibition in the retina

Nature Neuroscience, 2014
The reciprocal synapse between photoreceptors and horizontal cells underlies lateral inhibition and establishes the antagonistic center-surround receptive fields of retinal neurons to enhance visual contrast.
Tzu-Ming Wang, Lars C. Holzhausen, R. Kramer   +2 more
semanticscholar   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Proton–proton, anti-proton–anti-proton, proton–anti-proton correlations in Au + Au collisions measured by STAR at RHIC [PDF]

The European Physical Journal C, 2006
The analysis of two-particle correlations provides a powerful tool to study the properties of hot and dense matter created in heavy-ion collisions at ultra-relativistic energies. Applied to identical and non-identical hadron pairs, it makes the study of space-time evolution of the source in femtoscopic scale possible.
openaire   +1 more source

Inclusive production of protons, anti-protons, neutrons, deuterons and tritons in p+C collisions at 158 GeV/c beam momentum [PDF]

The European Physical Journal C, 2012
The production of protons, anti-protons, neutrons, deuterons and tritons in minimum bias p+C interactions is studied using a sample of 385 734 inelastic events obtained with the NA49 detector at the CERN SPS at 158 GeV/c beam momentum.
B. Baatar, G. Barr, J. Bartke, L. Betev, O. Chvála, J. Dolejsi, V. Eckardt, H. Fischer, Z. Fodor, A. Karev, V. Kolesnikov, M. Kowalski, M. Makariev, A. Malakhov, M. Mateev, G. Melkumov, A. Rybicki, N. Schmitz, P. Seyboth, R. Stock, G. Tinti, D. Varga, G. Vesztergombi, S. Wenig   +23 more
semanticscholar   +1 more source