Results 61 to 70 of about 257,792 (306)

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

New Insight on Damped Oscillating Regular Structures from “Effective” Proton Electromagnetic Form Factor Data

AppliedMath
An objective existence of damped oscillation regular structures from the proton “effective” electromagnetic form factor data, appearing when these data are described by a two parametric Tomasi-Gustafsson-Rekalo function, is investigated. If the same data
Stanislav Dubnička, Anna-Zuzana Dubničková, Lukáš Holka, Andrej Liptaj   +3 more
doaj   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Particle acceleration in the presence of weak turbulence at an X-type neutral point [PDF]

, 2012
We simulate the likely noisy situation near a reconnection region by superposing many 2D linear reconnection eigenmodes. The superposition of modes on the steady state X-type magnetic field creates multiple X- and O-type neutral points close to the ...
Petkaki, P., MacKinnon, A.L., Burge, C. A., MacKinnon, A. L., Burge, C.A.   +4 more
core   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Proton therapy for isolated local regional recurrence of breast cancer after mastectomy alone

Frontiers in Oncology, 2022
Purpose/ObjectivesTo assess adverse events (AEs) and disease-specific outcomes after proton therapy for isolated local-regional recurrence (LRR) of breast cancer after mastectomy without prior radiotherapy (RT).Materials/MethodsPatients were identified ...
Brady S. Laughlin, Ronik S. Bhangoo, Joshua R. Niska, Cameron S. Thorpe, Marlene E. Girardo, Justin D. Anderson, Heidi E. Kosiorek, Lisa A. McGee, William F. Hartsell, John H. Chang, Carl J. Rossi, Henry K. Tsai, Isabelle J. Choi, Carlos E. Vargas   +13 more
doaj   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Proton-proton bremsstrahlung

Nuclear Physics B, 1967
Abstract The differential and total cross section for the reaction p+p→p+p+ γ are evaluated by using a transition operator consisting of the standard electromagnetic interaction plus a part arising from exchange of pions between the two nucleons. The latter processes are treated by a simple semiphenomenological model.
W.A. Pearce, W.A. Gale, I.M. Duck
openaire   +2 more sources