The polarised gluon density Delta G(x) from di-jet events at high energy ep-colliders
, 2001 We present the potential to determine the polarised gluon density from boson-gluon fusion processes with di-jet events at future high energy ep-colliders.
A. De Roeck +9 more
core +2 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Primary and secondary particle contributions to the depth dose distribution in a phantom shielded from solar flare and Van Allen protons [PDF]
, 1972 Calculations have been made using the nucleon-meson transport code NMTC to estimate the absorbed dose and dose equivalent distributions in astronauts inside space vehicles bombarded by solar flare and Van Allen protons.
Alsmiller, R. G., Jr. +2 more
core +1 more source
Proton–proton, anti-proton–anti-proton, proton–anti-proton correlations in Au + Au collisions measured by STAR at RHIC [PDF]
The European Physical Journal C, 2006 The analysis of two-particle correlations provides a powerful tool to study the properties of hot and dense matter created in heavy-ion collisions at ultra-relativistic energies. Applied to identical and non-identical hadron pairs, it makes the study of space-time evolution of the source in femtoscopic scale possible.
openaire +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Strongly interacting neutrinos as the highest energy cosmic rays [PDF]
, 2003 We show that all features of the ultrahigh energy cosmic ray spectrum from 10^{17} eV to 10^{21} eV can be described with a simple power-like injection spectrum of protons under the assumption that the neutrino-nucleon cross-section is significantly ...
Fodor, Z. +3 more
core +1 more source
Directed flow of transported and non-transported protons in Au+Au collisions from UrQMD model
, 2012 The directed flow of inclusive, transported and non-transported (including produced) protons, as well as antiprotons, has been studied in the framework of Ultra-Relativistic Quantum Molecular Dynamics approach (UrQMD model) for Au+Au collisions at ...
Guo, Yao, Liu, Feng, Tang, Aihong
core +1 more source
Spectral and temporal signatures of ultrarelativistic protons in compact sources [PDF]
, 2005 We present calculations of the spectral and temporal radiative signatures expected from ultrarelativistic protons in compact sources. The coupling between the protons and the leptonic component is assumed to occur via Bethe-Heitler pair production.
Kirk, J. G. +2 more
core +2 more sources
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source