Results 1 to 10 of about 6,529,988 (173)

Efficient oral vaccination by bioengineering virus-like particles with protozoan surface proteins [PDF]

Nature Communications, 2019
Giardia lamblia express a dense coat of variant-specific surface proteins (VSPs) on trophozoites that protects the parasite inside the host´s intestine. Here the authors show that stability and immunomodulatory properties of VSPs can be exploited to both
Marianela C. Serradell, Lucía L. Rupil, Román A. Martino, César G. Prucca, Pedro G. Carranza, Alicia Saura, Elmer A. Fernández, Pablo R. Gargantini, Albano H. Tenaglia, Juan P. Petiti, Renata R. Tonelli, Nicolás Reinoso-Vizcaino, José Echenique, Luciana Berod, Eliane Piaggio, Bertrand Bellier, Tim Sparwasser, David Klatzmann, Hugo D. Luján   +18 more
doaj   +8 more sources

Down the membrane hole: Ion channels in protozoan parasites

PLoS Pathogens, 2022
Parasitic diseases caused by protozoans are highly prevalent around the world, disproportionally affecting developing countries, where coinfection with other microorganisms is common.
Veronica Jimenez, Sebastian Mesones
doaj   +3 more sources

Production of recombinant proteins from protozoan parasites [PDF]

Trends in Parasitology, 2010
Although the past decade has witnessed sequencing from an increasing number of parasites, modern high-throughput DNA sequencing technologies have the potential to generate complete genome sequences at even higher rates. Along with the discovery of genes that might constitute potential targets for chemotherapy or vaccination, the need for novel protein ...
José A, Fernández-Robledo, Gerardo R, Vasta   +1 more
openaire   +3 more sources

Cysteine proteases in protozoan parasites. [PDF]

PLoS Neglected Tropical Diseases, 2018
Cysteine proteases (CPs) play key roles in the pathogenesis of protozoan parasites, including cell/tissue penetration, hydrolysis of host or parasite proteins, autophagy, and evasion or modulation of the host immune response, making them attractive ...
Jair L Siqueira-Neto, Anjan Debnath, Laura-Isobel McCall, Jean A Bernatchez, Momar Ndao, Sharon L Reed, Philip J Rosenthal   +6 more
doaj   +2 more sources

ProtVirDB: a database of protozoan virulent proteins [PDF]

Bioinformatics, 2009
Abstract Summary: ProtVirDB is a comprehensive and user-friendly web-based knowledgebase of virulent proteins belonging to protozoan species. The database will facilitate research and provide an integrated platform for comparative studies of virulent proteins in different parasitic protozoans and organize them under a unifying ...
Dinesh Gupta, Jayashree Ramana
openaire   +4 more sources

Protein acetylation in the critical biological processes in protozoan parasites [PDF]

Trends in Parasitology, 2021
Protein lysine acetylation has emerged as a major regulatory post-translational modification in different organisms, present not only on histone proteins affecting chromatin structure and gene expression but also on nonhistone proteins involved in several cellular processes. The same scenario was observed in protozoan parasites after the description of
Suellen Rodrigues Maran, Krista Fleck, Natália Melquie Monteiro-Teles, Tony Isebe, Pegine Walrad, Victoria Jeffers, Igor Cestari, Elton J.R. Vasconcelos, Nilmar Moretti   +8 more
openaire   +6 more sources

Regulation of RNA binding proteins in trypanosomatid protozoan parasites

World Journal of Biological Chemistry, 2016
Posttranscriptional mechanisms have a critical role in the overall outcome of gene expression. These mechanisms are especially relevant in protozoa from the genus Trypanosoma, which is composed by death threatening parasites affecting people in Sub-saharan Africa or in the Americas.
Romaniuk, María Albertina, Cervini Bohm, Gabriela Marta , Cassola, Alejandro Carlos   +2 more
openaire   +4 more sources

Protein Lactylation Critically Regulates Energy Metabolism in the Protozoan Parasite Trypanosoma brucei [PDF]

Frontiers in Cell and Developmental Biology, 2021
Lysine lactylation has been recognized as a novel post-translational modification occurring on histones. However, lactylation in non-histone proteins, especially in proteins of early branching organisms, is not well understood. Energy metabolism and the histone repertoire in the early diverging protozoan parasite Trypanosoma brucei, the causative agent
Naiwen Zhang, Naiwen Zhang, Ning Jiang, Ning Jiang, Liying Yu, Liying Yu, Tiandong Guan, Tiandong Guan, Xiaoyu Sang, Xiaoyu Sang, Ying Feng, Ying Feng, Ran Chen, Ran Chen, Qijun Chen, Qijun Chen   +15 more
openaire   +4 more sources

Transport proteins determine drug sensitivity and resistance in a protozoan parasite, Trypanosoma brucei

Frontiers in Pharmacology, 2015
Drug resistance in pathogenic protozoa is very often caused by changes to the ‘transportome’ of the parasites. In Trypanosoma brucei, several transporters have been implicated in uptake of the main classes of drugs, diamidines and melaminophenyl ...
Jane Claire Munday, Luca eSettimo, Luca eSettimo, Harry P de Koning   +3 more
doaj   +2 more sources

Genome-Wide Identification of Novel miRNAs and Infection-Related Proteins in Leishmania major via Comparative Analysis of the Protozoa, Vectors, and Mammalian Hosts [PDF]

Pathogens
Leishmania major is a unicellular protozoan that causes cutaneous leishmaniasis in mammals and is mainly transmitted by the sand fly Phlebotomus papatasi.
Tianyi Liu, Jinyang Qian, Yicheng Yan, Xi Zeng, Zhiyuan Yang   +4 more
doaj   +2 more sources