Efficient oral vaccination by bioengineering virus-like particles with protozoan surface proteins [PDF]
Nature Communications, 2019 Giardia lamblia express a dense coat of variant-specific surface proteins (VSPs) on trophozoites that protects the parasite inside the host´s intestine. Here the authors show that stability and immunomodulatory properties of VSPs can be exploited to both
Marianela C. Serradell +18 more
doaj +8 more sources
Down the membrane hole: Ion channels in protozoan parasites
PLoS Pathogens, 2022 Parasitic diseases caused by protozoans are highly prevalent around the world, disproportionally affecting developing countries, where coinfection with other microorganisms is common.
Veronica Jimenez, Sebastian Mesones
doaj +3 more sources
Cysteine proteases in protozoan parasites. [PDF]
PLoS Neglected Tropical Diseases, 2018 Cysteine proteases (CPs) play key roles in the pathogenesis of protozoan parasites, including cell/tissue penetration, hydrolysis of host or parasite proteins, autophagy, and evasion or modulation of the host immune response, making them attractive ...
Jair L Siqueira-Neto +6 more
doaj +2 more sources
The NF-κB Pathway: Modulation by Entamoeba histolytica and Other Protozoan Parasites
Frontiers in Cellular and Infection Microbiology, 2021 Protozoan parasites have led to worldwide devastation because of their ability to cause infectious diseases. They have evolved as successful pathogens in part because of their remarkable and sophisticated ways to evade innate host defenses.
Attinder Chadha, Kris Chadee
doaj +2 more sources
Frontiers in Pharmacology, 2015 Drug resistance in pathogenic protozoa is very often caused by changes to the ‘transportome’ of the parasites. In Trypanosoma brucei, several transporters have been implicated in uptake of the main classes of drugs, diamidines and melaminophenyl ...
Jane Claire Munday +3 more
doaj +2 more sources
Genome-Wide Identification of Novel miRNAs and Infection-Related Proteins in Leishmania major via Comparative Analysis of the Protozoa, Vectors, and Mammalian Hosts [PDF]
PathogensLeishmania major is a unicellular protozoan that causes cutaneous leishmaniasis in mammals and is mainly transmitted by the sand fly Phlebotomus papatasi.
Tianyi Liu +4 more
doaj +2 more sources
Proteins of the Ciliated Protozoan Parasite Ichthyophthirius multifiliis Identified in Common Carp Skin Mucus [PDF]
Pathogens, 2021 The skin mucus is the fish primary defense barrier protecting from infections via the skin epidermis. In a previous study, we have investigated the proteome of common carp (Cyprinus carpio) skin mucus at two different time points (1 and 9 days) post ...
Mona Saleh +4 more
doaj +2 more sources
The ATP-binding cassette proteins of the deep-branching protozoan parasite Trichomonas vaginalis. [PDF]
PLoS Neglected Tropical Diseases, 2012 The ATP binding cassette (ABC) proteins are a family of membrane transporters and regulatory proteins responsible for diverse and critical cellular process in all organisms.
Christopher Kay +5 more
doaj +3 more sources
Hsp90 and associates shaping parasite biology [PDF]
mSphereHsp90 is considered to be the master regulator of chaperone activity within the cellular context. In addition to aiding client maturation and maintaining protein homeostasis, Hsp90 serves various non-canonical functions in model eukaryotes: ranging from ...
Abhilasha Gahlawat +2 more
doaj +2 more sources
Lysine Acetylation Is Widespread on Proteins of Diverse Function and Localization in the Protozoan Parasite Toxoplasma gondii [PDF]
Eukaryotic Cell, 2012 While histone proteins are the founding members of lysine acetylation substrates, it is now clear that hundreds of other proteins can be acetylated in multiple compartments of the cell.
Victoria Jeffers, William J. Sullivan
openalex +2 more sources