Results 111 to 120 of about 16,784 (210)

Combinations of isoform-targeted histone deacetylase inhibitors and bryostatin analogues display remarkable potency to activate latent HIV without global T-cell activation [PDF]

, 2017
Current antiretroviral therapy (ART) for HIV/AIDS slows disease progression by reducing viral loads and increasing CD4 counts. Yet ART is not curative due to the persistence of CD4+ T-cell proviral reservoirs that chronically resupply active virus ...
Albert, Brice J, Barnes, Alexander B, Kyei, George B, Marshall, Garland R, Niu, Austin, Ramani, Rashmi, Ratner, Lee, Wender, Paul A, Williams, Robert M   +8 more
core   +2 more sources

Development of a Next‐Generation Sequencing Protocol for Assessing Lenacapavir Resistance in HIV‐1 Capsid

Journal of Medical Virology, Volume 98, Issue 1, January 2026.
ABSTRACT Lenacapavir (LEN) is a first‐in‐class capsid inhibitor (CAI) that targets multiple stages of the HIV‐1 lifecycle, showing efficacy in heavily treatment‐experienced (HTE) individuals with multidrug‐resistance (MDR) and in pre‐exposure prophylaxis (PrEP). This study aimed to characterize a novel in‐house next‐generation sequencing (NGS) protocol
Omar El Khalili, Collins Ambe Chenwi, Daniele Spalletta, Greta Marchegiani, Luca Carioti, Hossein Eizadi Moghadam, Ada Bertoli, Vincenzo Spagnuolo, Maria Mercedes Santoro, Francesca Ceccherini‐Silberstein, Maria Concetta Bellocchi   +10 more
wiley   +1 more source

Human T-cell lymphotropic virus type I (HTLV-I) proviral DNA viral load among asymptomatic patients and patients with HTLV-I-associated myelopathy/tropical spastic paraparesis

Brazilian Journal of Medical and Biological Research, 2005
To evaluate the human T-cell lymphotropic virus type I (HTLV-I) proviral DNA load among asymptomatic HTLV-I-infected carriers and patients with HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP), real time PCR using TaqMan probes for the
P.A. Montanheiro, A.C. Penalva de Oliveira, M.P. Posada-Vergara, A.C. Milagres, C. Tauil, P.E. Marchiori, A.J.S. Duarte, J. Casseb   +7 more
doaj   +1 more source

Expansion in CD39(+) CD4(+) Immunoregulatory T Cells and Rarity of Th17 Cells in HTLV-1 Infected Patients Is Associated with Neurological Complications [PDF]

, 2013
HTLV-1 infection is associated with several inflammatory disorders, including the neurodegenerative condition HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). It is unclear why a minority of infected subjects develops HAM/TSP.
A El Hed, A Gessain, Aaron M. Hasenkrug, AB Carneiro-Proietti, Aluisio C. Segurado, AM Vine, B Asquith, B Galvao-Castro, C Grant, CE Ormsby, CR Maliszewski, D Favre, DJ Hartigan-O'Connor, Douglas F. Nixon, E Bettelli, E Hanon, E Matsuura, EN Benveniste, Esper G. Kallas, F Annunziato, F Toulza, F Toulza, F Umehara, Fabio E. Leal, Fatah Kashanchi, Fernanda R. Bruno, G Borsellino, G de The, G Gaudray, G Raimondi, GP Garlet, H Kebir, Harry Wynn-Williams, HT Jin, I Best, I Elovaara, IM Stromnes, J Arnold, J Michaelsson, J Wang, JH Richardson, JM Brenchley, JM Fletcher, JR Orland, K Arisawa, K Eguchi, K Etoh, K Hieshima, K Nishioka, Karina I. Carvalho, KJ Livak, KM Dwyer, LC Ndhlovu, LC Ndhlovu, LC Ndhlovu, LC Ndhlovu, LE Harrington, Lishomwa C. Ndhlovu, M Bellon, M Hisada, M Matsuoka, M Mochizuki, M Nagai, M Osame, M Saito, MD Dodon, OS Morgan, P Hollsberg, PK Goon, Q Tang, R Iannone, R Kubota, R Kubota, R Tandon, S Deaglio, S Hilburn, S Read, S Sakaguchi, S Sakaguchi, Sabri S. Sanabani, SE Macatonia, SF Ziegler, T Lehner, T Ohsugi, T Usui, T Zhao, TF Greten, TR Mosmann, U Oh, Walter K. Neto, Y Koyanagi, Y Satou, Y Yamano, Y Yamano, Y Yamano, Y Yamano   +95 more
core   +4 more sources

Genome editing technologies to fight infectious diseases [PDF]

, 2017
Genome editing by programmable nucleases represents a promising tool that could be exploited to develop new therapeutic strategies to fight infectious diseases.
Barzon, Luisa, Pal\ue3\ub9, Giorgio, Trevisan, Marta   +2 more
core   +1 more source

Neurological aspects of HTLV-1 infection in Bahia: results from an 8-year cohort

Arquivos de Neuro-Psiquiatria, 2015
HTLV-1 is the causal agent of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), a disease observed in up to 5% of individuals infected with HTLV-1.
Davi Tanajura
doaj   +1 more source

In Vivo validation of a bioinformatics based tool to identify reduced replication capacity in HIV-1. [PDF]

, 2010
Although antiretroviral drug resistance is common in treated HIV infected individuals, it is not a consistent indicator of HIV morbidity and mortality.
Kitchen, Christina MR, Kitchen, Scott G, Krogstad, Paul   +2 more
core   +2 more sources

Detection of Bovine Leukemia Virus in Argentine, Bolivian, Paraguayan and Cuban Native Cattle Using a Quantitative Real-Time PCR Assay-BLV-CoCoMo-qPCR-2

Pathogens
Bovine leukemia virus (BLV), an oncogenic retrovirus of the genus Deltaretrovirus, causes enzootic bovine leukosis (EBL), the most prevalent neoplastic disease in cattle and a major source of economic loss.
Guillermo Giovambattista, Aronggaowa Bao, Olivia Marcuzzi, Ariel Loza Vega, Juan Antonio Pereira Rico, Maria Florencia Ortega Masague, Liz Aurora Castro Rojas, Ruben Dario Martinez, Odalys Uffo Reinosa, Yoko Aida   +9 more
doaj   +1 more source

Estrogen receptor-1 is a key regulator of HIV-1 latency that imparts gender-specific restrictions on the latent reservoir. [PDF]

, 2018
Unbiased shRNA library screens revealed that the estrogen receptor-1 (ESR-1) is a key factor regulating HIV-1 latency. In both Jurkat T cells and a Th17 primary cell model for HIV-1 latency, selective estrogen receptor modulators (SERMs, i.e ...
Bacchetti, Peter, Chomont, Nicolas, Das, Biswajit, Deeks, Steven G, Dobrowolski, Curtis, Gandhi, Monica, Hoh, Rebecca, Johnston, Rowena, Karn, Jonathan, Luttge, Benjamin, Scully, Eileen, Valadkhan, Saba   +11 more
core  

Characterization of Intact Proviruses in Blood and Lymph Node from HIV-Infected Individuals Undergoing Analytical Treatment Interruption. [PDF]

, 2019
The role of lymphoid tissue as a potential source of HIV-1 rebound following interruption of antiretroviral therapy (ART) is uncertain. To address this issue, we compared the latent viruses obtained from CD4+ T cells in peripheral blood and lymph nodes ...
Ablanedo-Terrazas, Yuria, Barton, John P, Cohen, Yehuda Z, Damsgaard, Tine, Del Rio Estrada, Perla M, Denton, Paul W, Garcia Noceda, Marco, Lorenzi, Julio CC, Lu, Ching-Lan, Nussenzweig, Michel C, Oliveira, Thiago Y, Pai, Joy A, Reyes-Teran, Gustavo, Søgaard, Ole S, Tolstrup, Martin, Vibholm, Line K   +15 more
core   +1 more source