Results 91 to 100 of about 13,697 (197)

Lymphatic endothelium in health and disease [PDF]

, 2018
The lymphatic vascular system has an important role in the maintenance of tissue fluid pressure homeostasis, in the mediation of the afferent immune response via recruitment of antigen-presenting cells toward draining lymph nodes, and in the intestinal ...
Detmar, Michael, Jurisic, Giorgia
core  

Elevated CHI3L1 as a Potential Biomarker of Cognitive Dysfunction in Anti‐NMDAR Encephalitis: Evidence From Clinical Results and Mice Model

CNS Neuroscience &Therapeutics, Volume 32, Issue 1, January 2026.
Astrocyte‐derived CHI3L1 is elevated in both a mouse model and pediatric patients with anti‐NMDAR encephalitis, coinciding with impaired hippocampal neurogenesis and cognitive deficits. CHI3L1 may serve as a potential biomarker for long‐term cognitive dysfunction in anti‐NMDAR encephalitis. ABSTRACT Background Anti‐N‐methyl‐D‐aspartate receptor (NMDAR)
Yuhang Li, Ran Ding, Jiaxin Yang, Xiaoyue Yang, Ziyao Han, Xue Li, Jie Liu, Yan Jiang, Li Cheng, Jiannan Ma, Hanyu Luo, Li Jiang   +11 more
wiley   +1 more source

Single‐nucleus RNA sequencing reveals the distinct heterogeneity of primary pulmonary sarcomas (PPS) and pulmonary sarcomatoid carcinoma (PSC)

Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.
Single‐nucleus RNA sequencing (snRNA‐seq) maps the cellular diversity of pulmonary sarcomatoid carcinoma (PSC) and primary pulmonary sarcomas (PPS). AT2 cells, a major source of epithelial cells in PSC, underwent malignant transformation primarily through epithelial–mesenchymal transition, suggesting AT2 cells may serve as the origin of PSC.
Jianfei Zhu, Yanlu Xiong, Shouzheng Ma, Jun Wei, Jiakuan Chen, Wenchen Wang, Qianqian Duan, Qin Zhang, Dongsheng Chen, Wanglong Deng, Tao Jiang, Jie Lei   +11 more
wiley   +1 more source

High tissue MMP14 expression predicts worse survival in gastric cancer, particularly with a low PROX1

Cancer Medicine, 2019
Matrix metalloproteinase 14 (MMP14), a membrane‐associated matrix metalloproteinase, has been shown to influence the invasion and metastasis of several solid tumors.
Aaro Kasurinen, Silvia Gramolelli, Jaana Hagström, Alli Laitinen, Arto Kokkola, Yuichiro Miki, Kaisa Lehti, Masakazu Yashiro, Päivi M. Ojala, Camilla Böckelman, Caj Haglund   +10 more
doaj   +1 more source

A single-nucleus RNA-sequencing pipeline to decipher the molecular anatomy and pathophysiology of human kidneys [PDF]

, 2019
Defining cellular and molecular identities within the kidney is necessary to understand its organization and function in health and disease. Here we demonstrate a reproducible method with minimal artifacts for single-nucleus Droplet-based RNA sequencing (
Chen, Song, Gao, Derek, Gaut, Joseph, Hoshi, Masato, Jain, Sanjay, Kim, Eric H., Knoten, Amanda, Lake, Blue B., Plongthongkum, Nongluk, Salamon, Diane, Venkatesh, Ramakrishna, Vijayan, Anitha, Zhang, Kun   +12 more
core   +2 more sources

Spatial Transcriptomic Characteristics of the Aging Human Ovary

Aging Cell, Volume 25, Issue 1, January 2026.
Troughing constructing a comprehensive spatiotemporal aging atlas on young and aged human ovaries, we revealed distinct cell types, cellular interactions, and aging‐associated gene expression changes due to aging. Specially, we detected an increase in DLK1:NOTCH3 expression which may contribute to the dysregulation of ovarian functions.
Meiling Zhang, Fanghao Guo, Qing Zhang, Qianhui Hu, Di Sun, Yongjian Ma, Yanquan Li, Mengxi Guo, Haixia Ding, Ying Guo, Baicai Yang, Songmao Li, Ningxia Sun, Yuxuan Zheng, Wen Li   +14 more
wiley   +1 more source

Prox1 regulates the notch1-mediated inhibition of neurogenesis.

PLoS Biology, 2010
Activation of Notch1 signaling in neural progenitor cells (NPCs) induces self-renewal and inhibits neurogenesis. Upon neuronal differentiation, NPCs overcome this inhibition, express proneural genes to induce Notch ligands, and activate Notch1 in ...
Valeria Kaltezioti, Georgia Kouroupi, Maria Oikonomaki, Evangelia Mantouvalou, Athanasios Stergiopoulos, Aristidis Charonis, Hermann Rohrer, Rebecca Matsas, Panagiotis K Politis   +8 more
doaj   +1 more source

PROX1 promotes breast cancer invasion and metastasis through WNT/β-catenin pathway via interacting with hnRNPK [PDF]

, 2022
Lizhe Zhu, Qi Tian, Huan Gao, Kaijie Wu, Bo Wang, Guanqun Ge, Siyuan Jiang, Ke Wang, Can Zhou, Jianjun He, Peijun Liu, Yu Ren, Bin Wang   +12 more
openalex   +1 more source

Blood flow-induced Notch activation and endothelial migration enable vascular remodeling in zebrafish embryos. [PDF]

, 2018
Arteries and veins are formed independently by different types of endothelial cells (ECs). In vascular remodeling, arteries and veins become connected and some arteries become veins. It is unclear how ECs in transforming vessels change their type and how
Ablooglu, Ararat J, Groisman, Alex, Gutierrez, Edgar, Saikin, Semion K, Tkachenko, Eugene, Traver, David, Weijts, Bart   +6 more
core   +3 more sources

Circadian Clock Dysfunction Exacerbate Autistic‐Like Behaviour and Wnt/β‐Catenin Signalling Dysregulation in ASD Mice and Treatment of Melatonin

Journal of Cellular and Molecular Medicine, Volume 30, Issue 1, January 2026.
ABSTRACT Between 50% and 80% of children diagnosed with Autism Spectrum Disorder (ASD) are estimated to experience sleep disturbances, highlighting the importance of exploring the role of the circadian clock in ASD development. Previous studies have identified a potential link between Bmal1 deficiency and ASD in mouse models.
Yuxing Zhang, Yinan Chen, Wu Li, Liya Tang, Guangyu Wang, Jiangshan Li, Xiang Feng   +6 more
wiley   +1 more source