Cell Reports, 2014 Colorectal cancer (CRC) initiation and growth is often attributed to stem cells, yet little is known about the regulation of these cells. We show here that a subpopulation of Prox1-transcription-factor-expressing cells have stem cell activity in ...
Zoltán Wiener +11 more
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Decorin Evokes a Pro‐Lysosomal Pathway in Lymphatic Endothelial Cells
Proteoglycan Research, Volume 3, Issue 4, October 2025.ABSTRACT The lymphatic system is critical to the body's immune and circulatory system, and lymphangiogenesis, the development of new lymphatic vessels from pre‐existing ones, is a significant process capitalized upon by cancer during tumorigenesis. Decorin is a small leucine‐rich proteoglycan which we have previously shown to be anti‐tumorigenic and a ...
Gabriel J. Pascal +6 more
wiley +1 more source
Lymphatic endothelium in health and disease [PDF]
, 2018 The lymphatic vascular system has an important role in the maintenance of tissue fluid pressure homeostasis, in the mediation of the afferent immune response via recruitment of antigen-presenting cells toward draining lymph nodes, and in the intestinal ...
Detmar, Michael, Jurisic, Giorgia
core
Endogenous expression of FAD-linked PS1 impairs proliferation, neuronal differentiation and survival of adult hippocampal progenitors [PDF]
, 2013 BACKGROUND: Alzheimer’s disease (AD) is characterized by progressive memory loss and impaired cognitive function. Early-onset familial forms of the disease (FAD) are caused by inheritance of mutant genes encoding presenilin 1 (PS1) variants.
Karthikeyan Veeraraghavalu +3 more
core +1 more source
Differentiation state-specific mitochondrial dynamic regulatory networks are revealed by global transcriptional analysis of the developing chicken lens. [PDF]
, 2014 The mature eye lens contains a surface layer of epithelial cells called the lens epithelium that requires a functional mitochondrial population to maintain the homeostasis and transparency of the entire lens.
Anastas, Sara +9 more
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Capicua Refines Mossy Fiber–CA3 Axon Targeting in the Late Postnatal Hippocampus
The FASEB Journal, Volume 39, Issue 18, 30 September 2025.Loss of the neurodevelopmental disorder‐associated protein capicua (CIC) disrupts axon targeting in the late postnatal mouse hippocampus. Single‐nucleus transcriptomics and trajectory analysis reveal the absence of a mature granule neuron subtype and aberrant expression of axon guidance genes that are typically downregulated during granule neuron ...
Rebekah van Bruggen +3 more
wiley +1 more source
PLoS Biology, 2010 The dentate gyrus has an important role in learning and memory, and adult neurogenesis in the subgranular zone of the dentate gyrus may play a role in the acquisition of new memories.
Alfonso Lavado +4 more
doaj +1 more source
A single-nucleus RNA-sequencing pipeline to decipher the molecular anatomy and pathophysiology of human kidneys [PDF]
, 2019 Defining cellular and molecular identities within the kidney is necessary to understand its organization and function in health and disease. Here we demonstrate a reproducible method with minimal artifacts for single-nucleus Droplet-based RNA sequencing (
Chen, Song +12 more
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Characterization of the AP-1 μ1A and μ1B adaptins in zebrafish (Danio rerio) [PDF]
, 2010 Protein transport between the trans-Golgi network and endosomes is mediated by transport vesicles formed by the adaptor-protein complex AP-1, consisting of the adaptins γ1, β1, μ1, σ1.
BORSANI, Giuseppe +9 more
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Antagonistic action of Six3 and Prox1 at the gamma-crystallin promoter [PDF]
, 2001 Johannes Lengler
openalex +1 more source