Results 41 to 50 of about 13,697 (197)

Identifying Behavioral Phenotypes and Heterogeneity in Heart Valve Surface Endothelium [PDF]

, 2016
Heart valvular endothelial cells (VECs) are distinct from vascular endothelial cells (ECs), but have an uncertain context within the spectrum of known endothelial phenotypes, including lymphatic ECs (LECs).
Acosta, Francisca M., Balaoing, Liezl R., Blancas, Alicia A., Grande-Allen, K. Jane   +3 more
core   +1 more source

Matrix stiffness controls lymphatic vessel formation through regulation of a GATA2-dependent transcriptional program. [PDF]

, 2018
Tissue and vessel wall stiffening alters endothelial cell properties and contributes to vascular dysfunction. However, whether extracellular matrix (ECM) stiffness impacts vascular development is not known.
Calado, DP, Dierkes, C, Fielden, M, Frye, M, Harvey, NL, He, L, Kazenwadel, J, Kiefer, F, Martinez-Corral, I, Mäkinen, T, Ortsäter, H, Ostergaard, P, Salminen, M, Taddei, A   +13 more
core   +4 more sources

Intermediate progenitors support migration of neural stem cells into dentate gyrus outer neurogenic niches. [PDF]

, 2020
The hippocampal dentate gyrus (DG) is a unique brain region maintaining neural stem cells (NCSs) and neurogenesis into adulthood. We used multiphoton imaging to visualize genetically defined progenitor subpopulations in live slices across key stages of ...
Arnold, Sebastian J, Daza, Ray Am, Hevner, Robert F, Hodge, Rebecca D, Millen, Kathleen J, Nelson, Branden R, Tripathi, Prem Prakash   +6 more
core   +2 more sources

Comprehensive Analysis of Porcine Prox1 Gene and Its Relationship with Meat Quality Traits

Animals, 2019
Prox1 is involved in muscle fiber conversion, adult-onset obesity, and type 2 diabetes. However, information regarding porcine Prox1 and its relationship with meat quality traits is still unknown.
Chao Dong, Xiying Zhang, Kaiqing Liu, Bojiang Li, Zhe Chao, Aiwen Jiang, Rongyang Li, Pinghua Li, Honglin Liu, Wangjun Wu   +9 more
doaj   +1 more source

Canal cristae growth and fiber extension to the outer hair cells of the mouse ear require Prox1 activity.

PLoS ONE, 2010
BackgroundThe homeobox gene Prox1 is required for lens, retina, pancreas, liver, and lymphatic vasculature development and is expressed in inner ear supporting cells and neurons.Methodology/principal findingsWe have investigated the role of Prox1 in the ...
Bernd Fritzsch, Miriam Dillard, Alfonso Lavado, Natasha L Harvey, Israt Jahan   +4 more
doaj   +1 more source

All TIEd up: mechanisms of Schlemm's canal maintenance. [PDF]

, 2017
Glaucoma is a leading cause of blindness, with an estimated world-wide prevalence of 3.5% in members of the population older than 40 years of age. Elevated intraocular pressure as the result of abnormal resistance to aqueous humor drainage is a major ...
Jeremiah Bernier-Latmani, Lewis, Tatiana V. Petrova   +2 more
core   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Prox1 Inhibits Proliferation and Is Required for Differentiation of the Oligodendrocyte Cell Lineage in the Mouse.

PLoS ONE, 2015
Central nervous system injury induces a regenerative response in ensheathing glial cells comprising cell proliferation, spontaneous axonal remyelination, and limited functional recovery, but the molecular mechanisms are not fully understood.
Kentaro Kato, Daijiro Konno, Martin Berry, Fumio Matsuzaki, Ann Logan, Alicia Hidalgo   +5 more
doaj   +1 more source

Lack of relationship between PROX1 expression and clinicopathological parameters and prognosis in gastric cancer patients: a meta-analysis and TCGA analysis

BMC Gastroenterology, 2022
Background The relationship between PROX1 expression and clinicopathological characteristics and prognosis in patients with gastric cancer (GC) remain controversial.
Zirui Jia, Yuhang Wang, Jiacheng Gao, Guo Zu   +3 more
doaj   +1 more source

Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder. [PDF]

, 2015
Bipolar disorder is a complex neuropsychiatric disorder that is characterized by intermittent episodes of mania and depression; without treatment, 15% of patients commit suicide.
, Alda, Martin, Boyer, Leah, Brennand, Kristen J., Calabrese, Joseph R., Diffenderfer, Kenneth E., Eames, Tameji, Gage, Fred H., Kelsoe, John R., Kim, Yongsung, Marchetto, Maria C., McCarthy, Michael J., Mertens, Jerome, Mi, Shuangli, Nievergelt, Caroline M., Nurnberger, John I., Oedegaard, Ketil J., Pham, Son, Schafer, Simon T., Soltani, Sheila, Wang, Qiu-Wen, Yang, Bo, Yao, Jun, Yu, Diana X., Zandi, Peter P., Zhang, Jian, Zheng, Yi   +26 more
core   +1 more source