A novel multistep mechanism for initial lymphangiogenesis in mouse embryos based on ultramicroscopy [PDF]
, 2013 Peer ...
Adams, Ralf H. +9 more
core +3 more sources
All TIEd up: mechanisms of Schlemm's canal maintenance. [PDF]
, 2017 Glaucoma is a leading cause of blindness, with an estimated world-wide prevalence of 3.5% in members of the population older than 40 years of age. Elevated intraocular pressure as the result of abnormal resistance to aqueous humor drainage is a major ...
Jeremiah Bernier-Latmani +2 more
core +1 more source
Intermediate progenitors support migration of neural stem cells into dentate gyrus outer neurogenic niches. [PDF]
, 2020 The hippocampal dentate gyrus (DG) is a unique brain region maintaining neural stem cells (NCSs) and neurogenesis into adulthood. We used multiphoton imaging to visualize genetically defined progenitor subpopulations in live slices across key stages of ...
Arnold, Sebastian J +6 more
core +2 more sources
Cdk5 controls lymphatic vessel development and function by phosphorylation of Foxc2. [PDF]
, 2015 The lymphatic system maintains tissue fluid balance, and dysfunction of lymphatic vessels and valves causes human lymphedema syndromes. Yet, our knowledge of the molecular mechanisms underlying lymphatic vessel development is still limited. Here, we show
Adams, R.H. +12 more
core +2 more sources
Identifying Behavioral Phenotypes and Heterogeneity in Heart Valve Surface Endothelium [PDF]
, 2016 Heart valvular endothelial cells (VECs) are distinct from vascular endothelial cells (ECs), but have an uncertain context within the spectrum of known endothelial phenotypes, including lymphatic ECs (LECs).
Acosta, Francisca M. +3 more
core +1 more source
Comprehensive Analysis of Porcine Prox1 Gene and Its Relationship with Meat Quality Traits
Animals, 2019 Prox1 is involved in muscle fiber conversion, adult-onset obesity, and type 2 diabetes. However, information regarding porcine Prox1 and its relationship with meat quality traits is still unknown.
Chao Dong +9 more
doaj +1 more source
BMC Gastroenterology, 2022 Background The relationship between PROX1 expression and clinicopathological characteristics and prognosis in patients with gastric cancer (GC) remain controversial.
Zirui Jia +3 more
doaj +1 more source
A transgenic Prox1-Cre-tdTomato reporter mouse for lymphatic vessel research. [PDF]
PLoS ONE, 2015 The lymphatic vascular system plays an active role in immune cell trafficking, inflammation and cancer spread. In order to provide an in vivo tool to improve our understanding of lymphatic vessel function in physiological and pathological conditions, we ...
Roberta Bianchi +9 more
doaj +1 more source
Heterogeneity in VEGFR3 levels drives lymphatic vessel hyperplasia through cell-autonomous and non-cell-autonomous mechanisms [PDF]
, 2018 Incomplete delivery to the target cells is an obstacle for successful gene therapy approaches. Here we show unexpected effects of incomplete targeting, by demonstrating how heterogeneous inhibition of a growth promoting signaling pathway promotes tissue ...
Alitalo, Kari +6 more
core +1 more source
Advanced Science, EarlyView.FBXO44 promotes colorectal cancer progression by targeting FOXP1 for ubiquitin‐mediated degradation. This study reveals a phosphorylation‐dependent mechanism involving AURKA and highlights the FBXO44/FOXP1/Cyclin E2 axis as a potential therapeutic target in colorectal cancer.
Hongxu Nie +10 more
wiley +1 more source