Results 71 to 80 of about 13,697 (197)

IMMUNOHISTOCHEMICAL STUDY OF PROTEINS PROX1, CD133 AND CD38 IN GLIOBLASTOMAS OF THE VENTRICULARSUBVENTRICULAR ZONE AND THEIR EFFECT ON THE LIFE EXPECTANCY OF PATIENTS

Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова, 2020
Introduction. Glioblastoma (GBM) is one of the most malignant tumors. Currently, treatment options for GBM are limited, and patient survival rates over the past decades have not changed significantly.The objective of the study was a comparative study of ...
B. E. Galkovsky, L. B. Mitrofanova, Iu. S. Lakhina, D. A. Gulyaev, V. Y. Chirkin, N. A. Mitrofanov, I. V. Chistova   +6 more
doaj   +1 more source

Unraveling the Morphological and Functional Maturation Mechanisms Underlying Human Neural Development Using iPSCs‐Derived Neuronal Model

Advanced Science, EarlyView.
Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian, Yi‐Chun Ou, Zi‐Xian Zhang, Jie Cai, Si‐Qing Cai, Guo‐Gang Xing   +5 more
wiley   +1 more source

Postmitotic Prox1 Expression Controls the Final Specification of Cortical VIP Interneuron Subtypes [PDF]

, 2021
Tevye Jason Stachniak, Rahel Kästli, Olivia Hanley, Ali Özgür Argunşah, Elianne Grietje Theodora van der Valk, George Kanatouris, Theofanis Karayannis   +6 more
openalex   +1 more source

Tumor Extracellular Vesicles lncOSLMT Drives Lung Inflammatory Premetastatic Niche Formation in Osteosarcoma via m6A‐Dependent hnRNPA2B1/COX‐2 Axis

Advanced Science, EarlyView.
Tumor‐derived extracellular vesicles program inflammatory lung premetastatic niches through selective delivery of long noncoding RNAs. This work reveals EVs‐associated lncOSLMT as a key driver of lung fibroblast activation via m6A‐dependent PTGS2 stabilization.
Hongbo Li, Zehao Guo, Yutong Zou, Jiongfeng Zhang, Jixiang Shi, Xihong Fu, Jian Tu, Hao Yao, Xuanxuan Lu, Lili Wen, Xianbiao Xie   +10 more
wiley   +1 more source

Prox1-Heterozygosis Sensitizes the Pancreas to Oncogenic Kras-Induced Neoplastic Transformation

Neoplasia: An International Journal for Oncology Research, 2016
The current paradigm of pancreatic neoplastic transformation proposes an initial step whereby acinar cells convert into acinar-to-ductal metaplasias, followed by progression of these lesions into neoplasias under sustained oncogenic activity and ...
Yiannis Drosos, Geoffrey Neale, Jianming Ye, Leena Paul, Emin Kuliyev, Anirban Maitra, Anna L Means, M Kay Washington, Jerold Rehg, David B Finkelstein, Beatriz Sosa-Pineda   +10 more
doaj   +1 more source

Endocrine secretory granule production is caused by a lack of REST and intragranular secretory content and accelerated by PROX1 [PDF]

, 2022
Jun Ishii, Hanako Sato‐Yazawa, Korehito Kashiwagi, Kazuhiko Nakadate, M. Iwamoto, Kakeru Kohno, Chie Miyata-Hiramatsu, Meitetsu Masawa, Masato Onozaki, Shuhei Noda, Tadasuke Miyazawa, Megumi Takagi, Takuya Yazawa   +12 more
openalex   +1 more source

Spatial Transcriptomics of TMJ Reveals a Remodeling Fibroblast‐Immune Microenvironment Driving Arthritis Pain

Advanced Science, EarlyView.
Spatial transcriptomics reveals a remodeled fibroblast‐immune microenvironment in the temporomandibular joint (TMJ) during arthritis. By combining seqFISH with genetic mouse models, this study uncovers TMJ spatial cell atalas, macrophage‐fibroblast crosstalk, and cytokine signaling pathways driving TMJ inflammation and pain.
Ziying Lin, Supawadee Jariyasakulroj, Yang Shu, Jingyi Chen, Qing Chang, Pao‐Fen Ko, Yuyueyang Qiu, Feixiang Chen, David Ahn, Zhen Zhao, Jian‐Fu Chen   +10 more
wiley   +1 more source

lncRNA PROX1-AS1负调控miR-206对鼻咽癌细胞SUNE1增殖、迁移侵袭的影响

Zhongguo shiyan zhenduanxue, 2021
目的探讨长链非编码RNA(lncRNA)PROX1反义RNA1(PROX1-AS1)是否靶向miR-206影响鼻咽癌细胞SUNE1的增殖、迁移和侵袭。方法采用实时定量PCR(RT-qPCR)检测鼻咽癌组织和癌旁组织中PROX1-AS1和miR-206表达。双荧光素酶报告实验和RT-qPCR分析PROX1-AS1和miR-206靶向关系。细胞计数试剂盒(CCK-8)法、克隆形成实验、Transwell实验检测PROX1-AS1和miR-206表达对SUNE1细胞增殖活力、克隆形成数、迁移和侵袭细胞数的影响。
袁小卫, 王彦君, 熊健, 何学祥
doaj  

Dynamic expression of lamin B1 during adult neurogenesis in the vertebrate brain

Developmental Dynamics, EarlyView.
Abstract Background In mammals, specific brain regions such as the dentate gyrus (DG) of the hippocampus and the subventricular zone (SVZ) of the lateral ventricles harbor adult neural stem/progenitor cells (ANSPCs) that give rise to new neurons and contribute to structural and functional brain plasticity.
Diana Zhilina, Lizbeth A. Bolaños Castro, Juan Sebastian Eguiguren, Sara Zocher, Anne Karasinsky, Dimitri Widmer, Alexandre Espinós, Victor Borrell, Michael Brand, Kyoko Miura, Oliver Zierau, Maximina H. Yun, Tomohisa Toda   +12 more
wiley   +1 more source

Two rare PROX1 variants in patients with lymphedema

Molecular Genetics & Genomic Medicine, 2020
Background The PROX1 gene is specifically expressed in a subpopulation of endothelial cells that, by budding and sprouting, give rise to the lymphatic system.
Maurizio Ricci, Bruno Amato, Shila Barati, Rita Compagna, Dominika Veselenyiova, Sercan Kenanoglu, Liborio Stuppia, Tommaso Beccari, Mirko Baglivo, Danjela Kurti, Juraj Krajcovic, Roberta Serrani, Munis Dundar, Syed H. Basha, Pietro Chiurazzi, Matteo Bertelli   +15 more
doaj   +1 more source