Results 71 to 80 of about 13,248 (198)

Dynamic expression of lamin B1 during adult neurogenesis in the vertebrate brain

Developmental Dynamics, EarlyView.
Abstract Background In mammals, specific brain regions such as the dentate gyrus (DG) of the hippocampus and the subventricular zone (SVZ) of the lateral ventricles harbor adult neural stem/progenitor cells (ANSPCs) that give rise to new neurons and contribute to structural and functional brain plasticity.
Diana Zhilina, Lizbeth A. Bolaños Castro, Juan Sebastian Eguiguren, Sara Zocher, Anne Karasinsky, Dimitri Widmer, Alexandre Espinós, Victor Borrell, Michael Brand, Kyoko Miura, Oliver Zierau, Maximina H. Yun, Tomohisa Toda   +12 more
wiley   +1 more source

Prox1-Heterozygosis Sensitizes the Pancreas to Oncogenic Kras-Induced Neoplastic Transformation

Neoplasia: An International Journal for Oncology Research, 2016
The current paradigm of pancreatic neoplastic transformation proposes an initial step whereby acinar cells convert into acinar-to-ductal metaplasias, followed by progression of these lesions into neoplasias under sustained oncogenic activity and ...
Yiannis Drosos, Geoffrey Neale, Jianming Ye, Leena Paul, Emin Kuliyev, Anirban Maitra, Anna L Means, M Kay Washington, Jerold Rehg, David B Finkelstein, Beatriz Sosa-Pineda   +10 more
doaj   +1 more source

Four Pharmacogenomic Variants Strongly Linked to Corticosteroid‐Induced Avascular Necrosis in Children with Cancer

The Journal of Clinical Pharmacology, EarlyView.
Abstract Corticosteroids are effective anti‐cancer agents for treating hematologic malignancies in children. However, avascular necrosis (AVN) is a common and debilitating adverse effect, leading to bone death and impacting long‐term quality of life. This study aimed to uncover the genetic factors contributing to corticosteroid‐induced AVN in a well ...
Miguel Cordova‐Delgado, Erika N. Scott, Shahrad R. Rassekh, Catrina M. Loucks, Wan‐Chun Chang, Edward J. Raack, Jessica N. Trueman, Colin J. D. Ross, Bruce C. Carleton, the Canadian Pharmacogenomics Network for Drug Safety Consortium   +9 more
wiley   +1 more source

High-resolution 3D analysis of mouse small-intestinal stroma. [PDF]

, 2016
Here we detail a protocol for whole-mount immunostaining of mouse small-intestinal villi that can be used to generate high-resolution 3D images of all gut cell types, including blood and lymphatic vessel cells, neurons, smooth muscle cells, fibroblasts ...
A Sabine, A Sabine, AK Benson, C Moolenbeek, C Norrmén, C Reinhardt, E Bazigou, F Tatin, G Gabella, G Zarkada, GJ Gage, H Gerhardt, H Nurmi, J Bernier-Latmani, Jeremiah Bernier-Latmani, K Choe, M Costa, M Potente, M Simons, ME Pitulescu, PL Appleton, R Shayan, S Claxton, T Kamba, Tatiana V Petrova, TS Stappenbeck, TV Petrova, W Zheng, WS Garrett, Y Yang, Y-Y Fu   +30 more
core   +1 more source

Organoid‐based novel technology for antitumor drug screening

VIEW, EarlyView.
Organoids represent a cutting‐edge research model that closely mimics in vivo organ physiology, making them highly valuable for tumor immunotherapy drug screening. This review explores the integration of organoids with advanced technologies, such as gene editing, 3D bioprinting, and AI, highlighting novel fusion platforms and their applications.
Yu Su, Yuan Chen, Guanning Wei, Yihai Shi   +3 more
wiley   +1 more source

Two rare PROX1 variants in patients with lymphedema

Molecular Genetics & Genomic Medicine, 2020
Background The PROX1 gene is specifically expressed in a subpopulation of endothelial cells that, by budding and sprouting, give rise to the lymphatic system.
Maurizio Ricci, Bruno Amato, Shila Barati, Rita Compagna, Dominika Veselenyiova, Sercan Kenanoglu, Liborio Stuppia, Tommaso Beccari, Mirko Baglivo, Danjela Kurti, Juraj Krajcovic, Roberta Serrani, Munis Dundar, Syed H. Basha, Pietro Chiurazzi, Matteo Bertelli   +15 more
doaj   +1 more source

Specific glial populations regulate hippocampal morphogenesis [PDF]

, 2008
The hippocampus plays an integral role in spatial navigation, learning and memory, and is a major site for adult neurogenesis. Critical to these functions is the proper organization of the hippocampus during development. Radial glia are known to regulate
Barry, Guy, Gronostajski, Richard M., Lindwall, Charlotta, Little, Erica, Mason, Sharon, Michael Piper, Moldrich, Randal, Richards, Linda J., Sarkar, Anindita, Tole, Shubha   +9 more
core   +2 more sources

Age‐Associated Transcriptomic and Epigenetic Alterations in Mouse Hippocampus

Aging Cell, EarlyView.
Single‐nucleus multiome sequencing of hippocampus reveals aging‐dependent changes in gene expression and chromatin accessibility. Chromatin alterations in synaptic genes often occur without corresponding expression changes, suggesting a “susceptible” chromatin state.
Merve Bilgic, Rinka Obata, Vlada‐Iuliana Panfil, Ziying Zhu, Mai Saeki, Yukiko Gotoh, Yusuke Kishi   +6 more
wiley   +1 more source

Trans-ethnic Meta-analysis and Functional Annotation Illuminates the Genetic Architecture of Fasting Glucose and Insulin [PDF]

, 2016
Knowledge of the genetic basis of the type 2 diabetes (T2D)-related quantitative traits fasting glucose (FG) and insulin (FI) in African ancestry (AA) individuals has been limited. In non-diabetic subjects of AA (n = 20,209) and European ancestry (EA; n =
Adeyemo, Adebowale, Agyemang, Charles, An, Ping, Armstrong, Loren L, Arnett, Donna K, Becker, Diane M, Bentley, Amy R, Bielak, Lawrence F, Biggs, Mary L, Boerwinkle, Eric, Bottinger, Erwin P, Bowden, Donald W, Cade, Brian E, Chen, Guanjie, Chen, Wei-Min, Chen, Yii-Der Ida, Consortium, AAAG, Consortium, CARe, Consortium, COGENT-BP, Consortium, eMERGE, Consortium, MAGIC, Consortium, MEDIA, Correa, Adolfo, Couper, David J, Crawford, Dana C, Cushman, Mary, Dauriz, Marco, Delaney, Joseph AC, Drolet, Anne M, Dupuis, Josee, Edwards, Todd L, Eicher, John D, Evans, Daniel S, Evans, Michele K, Ferrucci, Luigi, Florez, Jose C, Fornage, Myriam, Franceschini, Nora, Fu, Yi-Ping, Gaulton, Kyle J, Goodarzi, Mark O, Gottesman, Omri, Guo, Xiuqing, Hara, Kazuo, Harris, Tamara B, Hayes, M Geoffrey, Hivert, Marie-France, Hong, Jaeyoung, Irvin, Marguerite R, Jensen, Richard A, Jhun, Min A, Johnson, Andrew D, Jr, Lowe William L, Kabagambe, Edmond Kato, Kao, WH Linda, Kardia, Sharon LR, Karter, Andrew J, Keller, Margaux F, Kho, Abel N, Kizer, Jorge R, Krauss, Ronald M, Lange, Leslie A, Langefeld, Carl D, Leong, Aaron, Li, Man, Li, Xiaohui, Liang, Jingling, Lipovich, Leonard, Liu, Ching-Ti, Liu, Jingmin, Liu, Simin, Liu, Yongmei, Loos, Ruth JF, Lu, Yingchang, Maruthur, Nisa, Meigs, James B, Miljkovic, Iva, Morris, Andrew P, Mosley, Thomas H, Nalls, Michael A, Nayak, Uma, Ng, Maggie CY, North, Kari E, Pacheco, Jennifer A, Palmer, Nicholette D, Pankow, James S, Patel, Sanjay R, Patrick, Alan L, Peyser, Patricia A, Porneala, Bianca C, Province, Michael A, Psaty, Bruce M, Raghavan, Sridharan, Rasmussen-Torvik, Laura J, Rice, Kenneth M, Rich, Stephen S, Rotimi, Charles N, Rotter, Jerome I, Rybin, Denis V, Sale, Michele M, Selvin, Elizabeth, Sims, Mario, Siscovick, David S, Smith, Jennifer A, Snijder, Marieke B, Stallings, Sarah C, Tajuddin, Salman M, Tanaka, Toshiko, Taylor, Kent D, Vaidya, Dhananjay, Wagenknecht, Lynne E, Wilson, James G, Wren, Mary P, Yanek, Lisa R, Yao, Jie, Zhao, Wei, Zhu, Xiaofeng, Ziegler, Julie T, Zmuda, Joseph M, Zonderman, Alan B, Zwinderman, Aeilko H   +120 more
core   +2 more sources

Organ‐Specific Dedifferentiation and Epigenetic Remodeling in In Vivo Reprogramming

Aging Cell, EarlyView.
Transient in vivo expression of Yamanaka factors (OSKM) enhances regenerative competence and rejuvenation across multiple tissues. We highlight mechanistic links between injury‐induced dedifferentiation and OSKM reprogramming, while emphasizing safety challenges and the need for precise spatiotemporal control to enable clinical translation.
Beom‐Ki Jo, Seung‐Yeon Lee, Hee‐Ji Eom, Jumee Kim, Hyuk‐Jin Cha   +4 more
wiley   +1 more source