Results 81 to 90 of about 13,697 (197)

High-resolution 3D analysis of mouse small-intestinal stroma. [PDF]

, 2016
Here we detail a protocol for whole-mount immunostaining of mouse small-intestinal villi that can be used to generate high-resolution 3D images of all gut cell types, including blood and lymphatic vessel cells, neurons, smooth muscle cells, fibroblasts ...
A Sabine, A Sabine, AK Benson, C Moolenbeek, C Norrmén, C Reinhardt, E Bazigou, F Tatin, G Gabella, G Zarkada, GJ Gage, H Gerhardt, H Nurmi, J Bernier-Latmani, Jeremiah Bernier-Latmani, K Choe, M Costa, M Potente, M Simons, ME Pitulescu, PL Appleton, R Shayan, S Claxton, T Kamba, Tatiana V Petrova, TS Stappenbeck, TV Petrova, W Zheng, WS Garrett, Y Yang, Y-Y Fu   +30 more
core   +1 more source

The segregation of Calb1, Calb2, and Prph neurons reveals distinct and mixed neuronal populations and projections to hair cells in the inner ear and central nuclei

Developmental Dynamics, EarlyView.
Three populations of hair cells have a distinct expression of Calb1 and Calb2. (A, A′D) The central is highly positive for Calb1 while surrounding HC are positive for Calb2. Later, a calyx forms primarily with Calb1. (B, B′, D′, D″) Saccule and utricle start out positive for Calb2 but will upregulate the Calb1 in the striola that is primarily forming ...
Jeong Han Lee, Ebenezer N. Yamoah, Jennifer Kersigo, Karen Elliott, Niya LaRoda, Gabriela Pavlinkova, Bernd Fritzsch   +6 more
wiley   +1 more source

Kaposi's sarcoma-associated herpesvirus promotes mesenchymal-to-endothelial transition by resolving the bivalent chromatin of PROX1 gene.

PLoS Pathogens, 2021
Increasing evidence suggests that Kaposi's sarcoma (KS) arises from Kaposi's sarcoma-associated herpesvirus (KSHV)-infected mesenchymal stem cells (MSCs) through mesenchymal-to-endothelial transition (MEndT).
Yao Ding, Weikang Chen, Zhengzhou Lu, Yan Wang, Yan Yuan   +4 more
doaj   +1 more source

Plasticity of differentiated cells in wound repair and tumorigenesis, Part II: Skin and intestine [PDF]

, 2018
Recent studies have identified and begun to characterize the roles of regenerative cellular plasticity in many organs. In Part I of our two-part Review, we discussed how cells reprogram following injury to the stomach and pancreas.
Burclaff, Joseph, Mills, Jason C
core   +2 more sources

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, EarlyView.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source

Prospero-related homeobox 1 (Prox1) at the crossroads of diverse pathways during adult neural fate specification

Frontiers in Cellular Neuroscience, 2015
Over the last decades, adult neurogenesis in the central nervous system (CNS) has emerged as a fundamental process underlying physiology and disease. Recent evidence indicates that the homeobox transcription factor Prox1 is a critical intrinsic regulator
Athanasios eStergiopoulos, Maximilianos eElkouris, Panagiotis K. Politis   +2 more
doaj   +1 more source

Trans-ethnic Meta-analysis and Functional Annotation Illuminates the Genetic Architecture of Fasting Glucose and Insulin [PDF]

, 2016
Knowledge of the genetic basis of the type 2 diabetes (T2D)-related quantitative traits fasting glucose (FG) and insulin (FI) in African ancestry (AA) individuals has been limited. In non-diabetic subjects of AA (n = 20,209) and European ancestry (EA; n =
Adeyemo, Adebowale, Agyemang, Charles, An, Ping, Armstrong, Loren L, Arnett, Donna K, Becker, Diane M, Bentley, Amy R, Bielak, Lawrence F, Biggs, Mary L, Boerwinkle, Eric, Bottinger, Erwin P, Bowden, Donald W, Cade, Brian E, Chen, Guanjie, Chen, Wei-Min, Chen, Yii-Der Ida, Consortium, AAAG, Consortium, CARe, Consortium, COGENT-BP, Consortium, eMERGE, Consortium, MAGIC, Consortium, MEDIA, Correa, Adolfo, Couper, David J, Crawford, Dana C, Cushman, Mary, Dauriz, Marco, Delaney, Joseph AC, Drolet, Anne M, Dupuis, Josee, Edwards, Todd L, Eicher, John D, Evans, Daniel S, Evans, Michele K, Ferrucci, Luigi, Florez, Jose C, Fornage, Myriam, Franceschini, Nora, Fu, Yi-Ping, Gaulton, Kyle J, Goodarzi, Mark O, Gottesman, Omri, Guo, Xiuqing, Hara, Kazuo, Harris, Tamara B, Hayes, M Geoffrey, Hivert, Marie-France, Hong, Jaeyoung, Irvin, Marguerite R, Jensen, Richard A, Jhun, Min A, Johnson, Andrew D, Jr, Lowe William L, Kabagambe, Edmond Kato, Kao, WH Linda, Kardia, Sharon LR, Karter, Andrew J, Keller, Margaux F, Kho, Abel N, Kizer, Jorge R, Krauss, Ronald M, Lange, Leslie A, Langefeld, Carl D, Leong, Aaron, Li, Man, Li, Xiaohui, Liang, Jingling, Lipovich, Leonard, Liu, Ching-Ti, Liu, Jingmin, Liu, Simin, Liu, Yongmei, Loos, Ruth JF, Lu, Yingchang, Maruthur, Nisa, Meigs, James B, Miljkovic, Iva, Morris, Andrew P, Mosley, Thomas H, Nalls, Michael A, Nayak, Uma, Ng, Maggie CY, North, Kari E, Pacheco, Jennifer A, Palmer, Nicholette D, Pankow, James S, Patel, Sanjay R, Patrick, Alan L, Peyser, Patricia A, Porneala, Bianca C, Province, Michael A, Psaty, Bruce M, Raghavan, Sridharan, Rasmussen-Torvik, Laura J, Rice, Kenneth M, Rich, Stephen S, Rotimi, Charles N, Rotter, Jerome I, Rybin, Denis V, Sale, Michele M, Selvin, Elizabeth, Sims, Mario, Siscovick, David S, Smith, Jennifer A, Snijder, Marieke B, Stallings, Sarah C, Tajuddin, Salman M, Tanaka, Toshiko, Taylor, Kent D, Vaidya, Dhananjay, Wagenknecht, Lynne E, Wilson, James G, Wren, Mary P, Yanek, Lisa R, Yao, Jie, Zhao, Wei, Zhu, Xiaofeng, Ziegler, Julie T, Zmuda, Joseph M, Zonderman, Alan B, Zwinderman, Aeilko H   +120 more
core   +2 more sources

Dysregulation of Rho‐Associated Coiled‐Coil Protein Kinase1 Depletes Neural Stem Cell Pool and Impairs Hippocampal Neurogenesis After Traumatic Brain Injury

Cell Proliferation, EarlyView.
Following TBI, hippocampal neurogenesis in mice is impaired and affects cognitive function. This impairment is associated with the upregulation of p‐AKT/AKT mediated by ROCK1. ABSTRACT Traumatic brain injury (TBI) represents a global health burden, often resulting in persistent neurological deficits due to impaired hippocampal neurogenesis ...
Chaoqun Yao, Long Jin, Jun Zhong, Qianying Huang, Zhongwei Bao, Shaolong Zhou, Chaohua Wang, Huanhuan Li, Xiaowei Yuan, Zhen Wang, Ning Du, Jingxuan Yu, Huanran Chen, Xuyang Zhang, Hongfei Ge, Jianheng Wu   +15 more
wiley   +1 more source

Empirical Investigation into the Limitations of the Normative Paired Sales Adjustment Method [PDF]

This study investigates the normative paired sales adjustment method employed by appraisers in the sales comparison approach. It finds that the method fails to account for the diminishing marginal price effects of property attributes.
Marvin L. Wolverton
core  

T Cell Exhaustion and Dendritic Cell‐Mediated Tertiary Lymphoid Structures (TLSs) Modulation Affect Response to Neoadjuvant Chemoradiotherapy in Microsatellite Stable Rectal Cancer

Advanced Science, Volume 13, Issue 4, 19 January 2026.
Using multi‐omics analysis, this study demonstrates that immune characteristics of the tumor microenvironment, rather than mutational profiles, are more strongly correlated with treatment response. Specifically, early exhausted T cells and tertiary lymphoid structures regulation by LAMP3⁺ dendritic cells emerge as key predictors of favorable outcomes ...
Miao Wang, Jiejun Shi, Kai Xu, Leyi Yu, Xiaomao Yin, Jiexuan Wang, Lin Zhu, Xin Yang, Jingjing Qian, Wenqiang Wang, Liangchen Zhu, Xuan Dai, Zekun Zhao, Jinran Wu, Dongsheng Li, Zhiqian Hu, Qi Huang, Xinxing Li   +17 more
wiley   +1 more source