Results 81 to 90 of about 13,248 (198)

Dysregulation of Rho‐Associated Coiled‐Coil Protein Kinase1 Depletes Neural Stem Cell Pool and Impairs Hippocampal Neurogenesis After Traumatic Brain Injury

Cell Proliferation, EarlyView.
Following TBI, hippocampal neurogenesis in mice is impaired and affects cognitive function. This impairment is associated with the upregulation of p‐AKT/AKT mediated by ROCK1. ABSTRACT Traumatic brain injury (TBI) represents a global health burden, often resulting in persistent neurological deficits due to impaired hippocampal neurogenesis ...
Chaoqun Yao, Long Jin, Jun Zhong, Qianying Huang, Zhongwei Bao, Shaolong Zhou, Chaohua Wang, Huanhuan Li, Xiaowei Yuan, Zhen Wang, Ning Du, Jingxuan Yu, Huanran Chen, Xuyang Zhang, Hongfei Ge, Jianheng Wu   +15 more
wiley   +1 more source

Neocortical neurogenesis: a proneural gene perspective

The FEBS Journal, EarlyView.
The neocortex is a mammalian‐specific brain region responsible for higher‐order cognitive functioning that shares fundamental similarities across species, but which is larger and more complex in humans. Proneural genes, encoding basic helix–loop–helix transcription factors (TFs), are evolutionarily conserved drivers of neurogenesis from fly to human ...
Lakshmy Vasan, Alexandra Moffat, Pierre Mattar, Carol Schuurmans   +3 more
wiley   +1 more source

The mysterious middlemen making your vision pop: understanding the function of amacrine cells

The Journal of Physiology, EarlyView.
Abstract figure legend This review aims to illustrate the diversity and function of amacrine cells in the retina. The diversity of amacrine cell subtypes is depicted based on morphology, stratification and neurotransmitter expression, along with their synaptic connectivity with bipolar and ganglion cells, emphasizing inhibitory and modulatory roles ...
Victor Calbiague‐Garcia, Deborah Varro, Thomas Buffet, Olivier Marre   +3 more
wiley   +1 more source

Empirical Investigation into the Limitations of the Normative Paired Sales Adjustment Method [PDF]

This study investigates the normative paired sales adjustment method employed by appraisers in the sales comparison approach. It finds that the method fails to account for the diminishing marginal price effects of property attributes.
Marvin L. Wolverton
core  

Blood flow-induced Notch activation and endothelial migration enable vascular remodeling in zebrafish embryos. [PDF]

, 2018
Arteries and veins are formed independently by different types of endothelial cells (ECs). In vascular remodeling, arteries and veins become connected and some arteries become veins. It is unclear how ECs in transforming vessels change their type and how
Ablooglu, Ararat J, Groisman, Alex, Gutierrez, Edgar, Saikin, Semion K, Tkachenko, Eugene, Traver, David, Weijts, Bart   +6 more
core   +3 more sources

Human Lymphatic Endothelial Cells Expressing NRASQ61R Model Characteristics of Kaposiform Lymphangiomatosis

Pediatric Blood &Cancer, Volume 72, Issue 11, November 2025.
ABSTRACT Kaposiform lymphangiomatosis (KLA) is a complex lymphatic anomaly characterized by lymphatic overgrowth and dysfunction. The goal of this study was to determine how the NRASQ61R variant found in the tissue of KLA patients impacts key characteristics of lymphatic endothelial cells (LEC).
Dermot A. Fox, C. Griffin McDaniel, Patricia Pastura, Timothy D. Le Cras   +3 more
wiley   +1 more source

Prox1 regulates the notch1-mediated inhibition of neurogenesis.

PLoS Biology, 2010
Activation of Notch1 signaling in neural progenitor cells (NPCs) induces self-renewal and inhibits neurogenesis. Upon neuronal differentiation, NPCs overcome this inhibition, express proneural genes to induce Notch ligands, and activate Notch1 in ...
Valeria Kaltezioti, Georgia Kouroupi, Maria Oikonomaki, Evangelia Mantouvalou, Athanasios Stergiopoulos, Aristidis Charonis, Hermann Rohrer, Rebecca Matsas, Panagiotis K Politis   +8 more
doaj   +1 more source

Plasticity of differentiated cells in wound repair and tumorigenesis, Part II: Skin and intestine [PDF]

, 2018
Recent studies have identified and begun to characterize the roles of regenerative cellular plasticity in many organs. In Part I of our two-part Review, we discussed how cells reprogram following injury to the stomach and pancreas.
Burclaff, Joseph, Mills, Jason C
core   +2 more sources

Expansion of the Phenotype of Lymphatic Anomalies Caused by Somatic Activating BRAF Variant

Pediatric Blood &Cancer, Volume 72, Issue 11, November 2025.
ABSTRACT Background The somatic activating variant in BRAF (p.V600E) was recently described as a novel cause of macrocystic head and neck lymphatic malformations in three individuals. Other recent studies profiling the genetic causes of more complex lymphatic anomalies identified this same pathogenic BRAF variant.
Michael D. Fox, Sumukh Kumar, Allison D. Britt, Abhay S. Srinivasan, Lea F. Surrey, Seth E. Vatsky, Alexandra J. Borst, Hakon Hakonarson, Dong Li, Sarah E. Sheppard, Kristen M. Snyder, Denise M. Adams   +11 more
wiley   +1 more source

Roles of miR‐181 Family Members in OSCC: Implications for Therapy and Diagnostics

Cancer Medicine, Volume 14, Issue 19, October 2025.
ABSTRACT Oral squamous cell carcinoma (OSCC) is a common and aggressive form of head and neck cancer, frequently associated with smoking, alcohol consumption, and HPV infection. MicroRNAs (miRNAs) are small, non‐coding RNA transcripts that play significant roles in cancer initiation and progression.
Alexandra Iulia Aghiorghiesei, Andreea Nutu, Nikolay Mehterov, Christos K. Kontos, Boyan Vladimirov, Rares Buduru, Cornelia Braicu, Ioana Berindan‐Neagoe   +7 more
wiley   +1 more source