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Cell Volume Regulation in the Proximal Tubule of Rat Kidney [PDF]
Bulletin of Mathematical Biology, 2017 We developed a dynamic model of a rat proximal convoluted tubule cell in order to investigate cell volume regulation mechanisms in this nephron segment. We examined whether regulatory volume decrease (RVD), which follows exposure to a hyposmotic peritubular solution, can be achieved solely via stimulation of basolateral K[Formula: see text] and ...
Aurélie Edwards, Anita T. Layton
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The Proximal Tubule and Albuminuria [PDF]
Journal of the American Society of Nephrology, 2014 Recent data highlight the role of the proximal tubule (PT) in reabsorbing, processing, and transcytosing urinary albumin from the glomerular filtrate. Innovative techniques and approaches have provided exciting insights into these processes, and numerous investigators have shown that selective PT cell defects lead to significant albuminuria, even ...
Dickson, Landon E. +3 more
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VPS34 functions in the proximal tubule. [PDF]
Nat Rev Nephrol, 2023 Allison SJ.
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Regulation of phosphate transport in proximal tubules [PDF]
Pflügers Archiv - European Journal of Physiology, 2008 Homeostasis of inorganic phosphate (P(i)) is primarily an affair of the kidneys. Reabsorption of the bulk of filtered P(i) occurs along the renal proximal tubule and is initiated by apically localized Na(+)-dependent P(i) cotransporters. Tubular P(i) reabsorption and therefore renal excretion of P(i) is controlled by a number of hormones, including ...
Biber, J +3 more
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Ontogeny of proximal tubule acidification
Kidney International, 1995 The proximal tubule is responsible for the reabsorption of 80% of the filtered load of bicarbonate in adults. Proximal tubule bicarbonate reabsorption is affected by a number of hormones, acid-base balance, and the extracellular fluid volume status [1]. The adult proximal tubule thus plays a central role in acid-base homeostasis.
Michel Baum, Raymond Quigley
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Transcriptional profiling of the zebrafish proximal tubule [PDF]
American Journal of Physiology-Renal Physiology, 2019 The hepatocyte nuclear factor-1β (Hnf1b) transcription factor is a key regulator of kidney tubule formation and is associated with a syndrome of renal cysts and early onset diabetes. To further our understanding of Hnf1b in the developing zebrafish kidney, we performed RNA sequencing analysis of proximal tubules from hnf1b-deficient larvae.
Veronika Sander +6 more
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BMP-7 and the proximal tubule [PDF]
Kidney International, 2002 Bone morphogenetic protein-7 (BMP-7), also known as ostegenic protein-1, is a member of the transforming growth factor- (TGF-) superfamily that is expressed widely in embryonic life and plays a critical role in renal development (reviewed in1). BMP-7 is expressed particularly by the ureteric bud and also by the nephrogenic mesenchyme and the collecting
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Determinants of the effect of furosemide on the proximal tubule
Kidney International, 1972 Determinants of the effect of furosemide on the proximal tubule.The recollection renal micropuncture technique was used to assess fractional and, on occasion, absolute volume reabsorption in the dog late proximal tubule before and during a furosemide diuresis in which urine losses were or were not replaced.Similar observations were made before and ...
James R. Clapp +2 more
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The Proximal Tubule in Cystinosis [PDF]
Journal of the American Society of Nephrology, 2014 Although rare, nephropathic cystinosis is a devastating monogenic disorder leading to renal failure in the second decade of life. Fanconi syndrome, the initial renal manifestation of cystinosis in the young child, established the proximal tubule as a primary target of injury now recognized as ...
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Ontogeny of NHE8 in the rat proximal tubule [PDF]
American Journal of Physiology-Renal Physiology, 2007 Proximal tubule bicarbonate reabsorption is primarily mediated via the Na+/H+ exchanger, identified as NHE3 in adults. Previous studies have demonstrated a maturational increase in rat proximal tubule NHE3 expression, with a paucity of NHE3 expression in neonates, despite significant Na+-dependent proton secretion. Recently, a novel Na+/H+ antiporter (
Vangipuram Dwarakanath +6 more
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