Results 1 to 10 of about 611,505 (395)

miR-127 protects proximal tubule cells against ischemia/reperfusion: identification of kinesin family member 3B as miR-127 target. [PDF]

PLoS ONE, 2012
Ischemia/reperfusion (I/R) is at the basis of renal transplantation and acute kidney injury. Molecular mechanisms underlying proximal tubule response to I/R will allow the identification of new therapeutic targets for both clinical settings.
Elia Aguado-Fraile, Edurne Ramos, David Sáenz-Morales, Elisa Conde, Ignacio Blanco-Sánchez, Konstantinos Stamatakis, Luis del Peso, Edwin Cuppen, Bernhard Brüne, María Laura García Bermejo   +9 more
doaj   +27 more sources

3D proximal tubule-on-chip model derived from kidney organoids with improved drug uptake

Scientific Reports, 2022
Three-dimensional, organ-on-chip models that recapitulate kidney tissue are needed for drug screening and disease modeling. Here, we report a method for creating a perfusable 3D proximal tubule model composed of epithelial cells isolated from kidney ...
Jeffrey O. Aceves, Szilvia Heja, Kenichi Kobayashi, Sanlin S. Robinson, Tomoya Miyoshi, Takuya Matsumoto, Olivier J. M. Schäffers, Ryuji Morizane, Jennifer A. Lewis   +8 more
doaj   +2 more sources

Mitochondrial organization in the developing proximal tubule is controlled by LRRK2 [PDF]

Nature Communications
The proximal tubule of the nephron performs energy-demanding functions such as resorption of water, amino acids and glucose. Formation of the energy-producing machinery is an essential step in proximal tubule epithelial cell differentiation, and this ...
Mohsina Khan, Kyle Bond, Elyse Grilli, Daniel Cameron, Liyang Zhao, Sunder Sims-Lucas, Andrew P. McMahon, Thomas J. Carroll, Leif Oxburgh   +8 more
doaj   +2 more sources

Proximal Tubule-Derived Amphiregulin Amplifies and Integrates Profibrotic EGF Receptor Signals in Kidney Fibrosis. [PDF]

Journal of the American Society of Nephrology, 2019
BACKGROUND Sustained activation of EGF receptor (EGFR) in proximal tubule cells is a hallmark of progressive kidney fibrosis after AKI and in CKD. However, the molecular mechanisms and particular EGFR ligands involved are unknown.
Eirini Kefaloyianni, Manikanda Raja Keerthi Raja, Julian Schumacher, Muthu L. Muthu, Vaishali Krishnadoss, S. Waikar, Andreas Herrlich   +6 more
semanticscholar   +2 more sources

Exosomal GAPDH from Proximal Tubule Cells Regulate ENaC Activity. [PDF]

PLoS ONE, 2016
Exosomes are nanometer-scale, cell-derived vesicles that contain various molecules including nucleic acids, proteins, and lipids. These vesicles can release their cargo into adjacent or distant cells and mediate intercellular communication and cellular ...
Kishore Kumar Jella, Ling Yu, Qiang Yue, Daniel Friedman, Billie J Duke, Abdel A Alli   +5 more
doaj   +2 more sources

YAP Activation in Renal Proximal Tubule Cells Drives Diabetic Renal Interstitial Fibrogenesis

Diabetes, 2020
An increasing number of studies suggest that the renal proximal tubule is a site of injury in diabetic nephropathy (DN), and progressive renal tubulointerstitial fibrosis is an important mediator of progressive kidney dysfunction in DN. In this study, we
Jianchun Chen, Xiaoyong Wang, Qian He, N. Bulus, A. Fogo, Ming-Zhi Zhang, Raymond C. Harris   +6 more
semanticscholar   +2 more sources

Tubulointerstitial injury and proximal tubule albumin transport in early diabetic nephropathy induced by type 1 diabetes mellitus [PDF]

, 2017
A decrease in the tubular expression of albumin endocytic transporters megalin and cubilin has been associated with diabetic nephropathy (DN), but there are no comprehensive studies to date relating early tubulointerstitial injury and the effect of the ...
Bahamonde, Javiera, Ezquer, Fernando, Ezquer, Marcelo, Giraud Billoud, Maximiliano German   +3 more
core   +2 more sources

Comparative Analysis of Proximal Tubule Cell Sources for In Vitro Studies of Renal Proximal Tubule Toxicity [PDF]

Biomedicines
Background/Objectives: The kidneys are essential for eliminating drugs and chemicals from the human body and renal epithelial cells are particularly vulnerable to damage caused by xenobiotics and their metabolites. Drug-induced kidney toxicity is a major
Courtney Sakolish, Han-Hsuan D. Tsai, Hsing-Chieh Lin, Piyush Bajaj, Remi Villenave, Stephen S. Ferguson, Jason P. Stanko, Richard A. Becker, Philip Hewitt, Weihsueh A. Chiu, Ivan Rusyn   +10 more
doaj   +2 more sources

Sustained alterations in proximal tubule gene expression in primary culture associate with HNF4A loss [PDF]

Scientific Reports
Primary cultures of proximal tubule cells are widely used to model the behavior of kidney epithelial cells in vitro. However, de-differentiation of primary cells upon culture has been observed and appreciated for decades, yet the mechanisms driving this ...
Asha C. Telang, Jenna T. Ference-Salo, Madison C. McElliott, Mahboob Chowdhury, Jeffrey A. Beamish   +4 more
doaj   +2 more sources

Proximal tubule dysfunction is associated with podocyte damage biomarkers nephrin and vascular endothelial growth factor in type 2 diabetes mellitus patients: a cross-sectional study. [PDF]

PLoS ONE, 2014
There is an ongoing debate as to whether early diabetic nephropathy in Type 2 diabetes mellitus may be attributed to the glomerulus or to the proximal tubule.
Ligia Petrica, Adrian Vlad, Gheorghe Gluhovschi, Florica Gadalean, Victor Dumitrascu, Cristina Gluhovschi, Silvia Velciov, Flaviu Bob, Daliborca Vlad, Roxana Popescu, Oana Milas, Sorin Ursoniu   +11 more
doaj   +2 more sources