miR-127 protects proximal tubule cells against ischemia/reperfusion: identification of kinesin family member 3B as miR-127 target. [PDF]
PLoS ONE, 2012 Ischemia/reperfusion (I/R) is at the basis of renal transplantation and acute kidney injury. Molecular mechanisms underlying proximal tubule response to I/R will allow the identification of new therapeutic targets for both clinical settings.
Elia Aguado-Fraile +9 more
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Sustained alterations in proximal tubule gene expression in primary culture associate with HNF4A loss [PDF]
Scientific ReportsPrimary cultures of proximal tubule cells are widely used to model the behavior of kidney epithelial cells in vitro. However, de-differentiation of primary cells upon culture has been observed and appreciated for decades, yet the mechanisms driving this ...
Asha C. Telang +4 more
doaj +2 more sources
Comparative Analysis of Proximal Tubule Cell Sources for In Vitro Studies of Renal Proximal Tubule Toxicity [PDF]
BiomedicinesBackground/Objectives: The kidneys are essential for eliminating drugs and chemicals from the human body and renal epithelial cells are particularly vulnerable to damage caused by xenobiotics and their metabolites. Drug-induced kidney toxicity is a major
Courtney Sakolish +10 more
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Proximal tubule cell maturation rate and function are controlled by PPARα signaling in kidney organoids [PDF]
Communications BiologyHuman pluripotent stem cell-derived kidney organoids are expected to be a useful tool for new drug discoveries, however, the immaturation of kidney organoids causes difficulties in recapitulating renal pharmacokinetics using organoids. Here, we performed
Yoshiki Sahara +3 more
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Stem cells derived from neonatal mouse kidney generate functional proximal tubule-like cells and integrate into developing nephrons in vitro. [PDF]
PLoS ONE, 2013 We have recently shown that kidney-derived stem cells (KSCs) isolated from the mouse newborn kidney differentiate into a range of kidney-specific cell types.
Egon Ranghini +5 more
doaj +6 more sources
Renal proximal tubule cells: power and finesse [PDF]
The Journal of Clinical Investigation, 2023 The proximal tubule is the high-capacity reabsorptive powerhouse of the kidney. Two papers in recent issues of the JCI highlight mechanisms of more delicate effects of the proximal tubule. Yoon et al.
Michaela A.A. Fuchs, Myles Wolf
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Crosstalk with renal proximal tubule cells drives acidosis-induced inflammatory response and dedifferentiation of fibroblasts via p38-singaling [PDF]
Cell Communication and SignalingBackground Tubulointerstitial kidney disease associated microenvironmental dysregulation, like acidification, inflammation and fibrosis, affects tubule cells and fibroblasts.
Marie-Christin Schulz +2 more
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Generation of proximal tubule spheroids for nephrotoxicity assessment [PDF]
Organoid, 2022 Background To date, nephrotoxicity in new drug development has been evaluated through two-dimensional culture of representative cell lines, such as HK-2 and human proximal tubule epithelial cells (hPTECs). Approximately 20% of new drugs that were safe in
Dae Hun Kim +3 more
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Prevalence of nephropathy and proximal tubule disorder in human immunodeficiency virus patients under tenofovir therapy [PDF]
Journal of Nephropharmacology, 2022 Introduction: Tenofovir is a common therapy in human immunodeficiency virus (HIV) patients. Objective: This study was carried out to determine the prevalence of nephropathy and proximal tubule disorder in HIV patients under tenofovir therapy.
Foroogh Sabzghabaei +5 more
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Generation and characterization of an inducible renal proximal tubule-specific CreERT2 mouse
Frontiers in Cell and Developmental Biology, 2023 Protein reabsorption in renal proximal tubules is essential for maintaining nutrient homeostasis. Renal proximal tubule-specific gene knockout is a powerful method to assess the function of genes involved in renal proximal tubule protein reabsorption ...
Shiting Liang +7 more
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