Results 11 to 20 of about 93,932 (331)
Cell volume regulation in the proximal tubule of rat kidney proximal tubule cell volume regulation [PDF]
Bulletin of Mathematical Biology, 2017 We developed a dynamic model of a rat proximal convoluted tubule cell in order to investigate cell volume regulation mechanisms in this nephron segment.
Edwards, Aurelie, Layton, Anita T.
core +6 more sources
VPS34 functions in the proximal tubule. [PDF]
Nat Rev Nephrol, 2023 Allison SJ.
europepmc +3 more sources
PLoS ONE, 2022 Metallothionein 3 (MT-3) is a small, cysteine-rich protein that binds to essential metals required for homeostasis, as well as to heavy metals that have the potential to exert toxic effects on cells.
Gazal Kalyan +8 more
doaj +2 more sources
Communications Biology, 2023 Of late, numerous microphysiological systems have been employed to model the renal proximal tubule. Yet there is lack of research on refining the functions of the proximal tubule epithelial layer—selective filtration and reabsorption.
Ramin Banan Sadeghian +7 more
doaj +1 more source
Micromachines, 2021 Kidney microphysiological systems (MPS) serve as potentially valuable preclinical instruments in probing mechanisms of renal clearance and osmoregulation. Current kidney MPS models target regions of the nephron, such as the glomerulus and proximal tubule
Stephanie Y. Zhang, Gretchen J. Mahler
doaj +1 more source
The Proximal Tubule and Albuminuria [PDF]
Journal of the American Society of Nephrology, 2014 Recent data highlight the role of the proximal tubule (PT) in reabsorbing, processing, and transcytosing urinary albumin from the glomerular filtrate. Innovative techniques and approaches have provided exciting insights into these processes, and numerous investigators have shown that selective PT cell defects lead to significant albuminuria, even ...
Dickson, Landon E. +3 more
openaire +3 more sources
Far infrared radiation promotes rabbit renal proximal tubule cell proliferation and functional characteristics, and protects against cisplatin-induced nephrotoxicity. [PDF]
PLoS ONE, 2017 Far infrared radiation, a subdivision of the electromagnetic spectrum, is beneficial for long-term tissue healing, anti-inflammatory effects, growth promotion, sleep modulation, acceleration of microcirculation, and pain relief.
I-Ni Chiang +3 more
doaj +1 more source
Functional Evaluation and Nephrotoxicity Assessment of Human Renal Proximal Tubule Cells on a Chip
Biosensors, 2022 An in vitro human renal proximal tubule model that represents the proper transporter expression and pronounced epithelial polarization is necessary for the accurate prediction of nephrotoxicity. Here, we constructed a high-throughput human renal proximal
Bolin Jing +5 more
doaj +1 more source
Exosomal GAPDH from Proximal Tubule Cells Regulate ENaC Activity. [PDF]
PLoS ONE, 2016 Exosomes are nanometer-scale, cell-derived vesicles that contain various molecules including nucleic acids, proteins, and lipids. These vesicles can release their cargo into adjacent or distant cells and mediate intercellular communication and cellular ...
Kishore Kumar Jella +5 more
doaj +1 more source
Cells, 2022 Diabetic kidney disease (DKD) remains the leading cause of end-stage kidney disease despite decades of study. Alterations in the glomerulus and kidney tubules both contribute to the pathogenesis of DKD although the majority of investigative efforts have ...
Kimberly S. Collins +14 more
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