miR-127 protects proximal tubule cells against ischemia/reperfusion : identification of Kinesin family member 3B as miR-127 target [PDF]
PLoS ONE, 2012 Ischemia/reperfusion (I/R) is at the basis of renal transplantation and acute kidney injury. Molecular mechanisms underlying proximal tubule response to I/R will allow the identification of new therapeutic targets for both clinical settings.
Aguado-Fraile, Elia +9 more
core +23 more sources
Exosomal GAPDH from Proximal Tubule Cells Regulate ENaC Activity. [PDF]
PLoS ONE, 2016 Exosomes are nanometer-scale, cell-derived vesicles that contain various molecules including nucleic acids, proteins, and lipids. These vesicles can release their cargo into adjacent or distant cells and mediate intercellular communication and cellular ...
Kishore Kumar Jella +5 more
doaj +2 more sources
Proximal tubule dysfunction is associated with podocyte damage biomarkers nephrin and vascular endothelial growth factor in type 2 diabetes mellitus patients: a cross-sectional study. [PDF]
PLoS ONE, 2014 There is an ongoing debate as to whether early diabetic nephropathy in Type 2 diabetes mellitus may be attributed to the glomerulus or to the proximal tubule.
Ligia Petrica +11 more
doaj +2 more sources
Flow stimulated endocytosis in the proximal tubule [PDF]
Current Opinion in Nephrology and Hypertension, 2015 The proximal tubule plays a critical role in the reabsorption of ions, solutes and low molecular weight proteins from the glomerular filtrate. Although the proximal tubule has long been known to acutely modulate ion reabsorption in response to changes in flow rates of the glomerular filtrate, it has only recently been discovered that proximal tubule ...
Ora A. Weisz, Venkatesan Raghavan
openaire +4 more sources
Stem Cells Derived from Neonatal Mouse Kidney Generate Functional Proximal Tubule-Like Cells and Integrate into Developing Nephrons In Vitro [PDF]
PLoS ONE, 2013 We have recently shown that kidney-derived stem cells (KSCs) isolated from the mouse newborn kidney differentiate into a range of kidney-specific cell types.
Edgar, David +5 more
core +7 more sources
Sustained alterations in proximal tubule gene expression in primary culture associate with HNF4A loss. [PDF]
Sci RepPrimary cultures of proximal tubule cells are widely used to model the behavior of kidney epithelial cells in vitro. However, de-differentiation of primary cells upon culture has been observed and appreciated for decades, yet the mechanisms driving this ...
Telang AC +4 more
europepmc +2 more sources
Generation and characterization of an inducible renal proximal tubule-specific CreERT2 mouse. [PDF]
Front Cell Dev Biol, 2023 Protein reabsorption in renal proximal tubules is essential for maintaining nutrient homeostasis. Renal proximal tubule-specific gene knockout is a powerful method to assess the function of genes involved in renal proximal tubule protein reabsorption ...
Liang S +7 more
europepmc +2 more sources
Proximal tubule cell maturation rate and function are controlled by PPARα signaling in kidney organoids. [PDF]
Commun BiolHuman pluripotent stem cell-derived kidney organoids are expected to be a useful tool for new drug discoveries, however, the immaturation of kidney organoids causes difficulties in recapitulating renal pharmacokinetics using organoids. Here, we performed
Sahara Y +3 more
europepmc +2 more sources
Generation of proximal tubule spheroids for nephrotoxicity assessment [PDF]
Organoid, 2022 Background To date, nephrotoxicity in new drug development has been evaluated through two-dimensional culture of representative cell lines, such as HK-2 and human proximal tubule epithelial cells (hPTECs). Approximately 20% of new drugs that were safe in
Dae Hun Kim +3 more
doaj +1 more source
Physiological Reviews, 2022 For nearly fifty years the proximal tubule has been known to reabsorb, process, and either catabolize or transcytose albumin from the glomerular filtrate.
B. Molitoris +3 more
semanticscholar +1 more source