Results 11 to 20 of about 611,505 (395)
Cell volume regulation in the proximal tubule of rat kidney proximal tubule cell volume regulation [PDF]
Bulletin of Mathematical Biology, 2017 We developed a dynamic model of a rat proximal convoluted tubule cell in order to investigate cell volume regulation mechanisms in this nephron segment.
Edwards, Aurelie, Layton, Anita T.
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Proximal tubule cell maturation rate and function are controlled by PPARα signaling in kidney organoids [PDF]
Communications BiologyHuman pluripotent stem cell-derived kidney organoids are expected to be a useful tool for new drug discoveries, however, the immaturation of kidney organoids causes difficulties in recapitulating renal pharmacokinetics using organoids. Here, we performed
Yoshiki Sahara +3 more
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Generation of proximal tubule spheroids for nephrotoxicity assessment [PDF]
Organoid, 2022 Background To date, nephrotoxicity in new drug development has been evaluated through two-dimensional culture of representative cell lines, such as HK-2 and human proximal tubule epithelial cells (hPTECs). Approximately 20% of new drugs that were safe in
Dae Hun Kim +3 more
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Physiological Reviews, 2022 For nearly fifty years the proximal tubule has been known to reabsorb, process, and either catabolize or transcytose albumin from the glomerular filtrate.
B. Molitoris +3 more
semanticscholar +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance A single acute kidney injury event increases the risk of progression to chronic kidney disease (CKD). Combining single-nucleus RNA sequencing with genetic tracing of injured proximal tubule cells identified a spatially dynamic, evolving ...
Louisa M. S. Gerhardt +4 more
semanticscholar +1 more source
The proximal tubule and albuminuria: really! [PDF]
Journal of the American Society of Nephrology, 2014 Recent data highlight the role of the proximal tubule (PT) in reabsorbing, processing, and transcytosing urinary albumin from the glomerular filtrate. Innovative techniques and approaches have provided exciting insights into these processes, and numerous investigators have shown that selective PT cell defects lead to significant albuminuria, even ...
Landon E Dickson +3 more
semanticscholar +3 more sources
Prevalence of nephropathy and proximal tubule disorder in human immunodeficiency virus patients under tenofovir therapy [PDF]
Journal of Nephropharmacology, 2022 Introduction: Tenofovir is a common therapy in human immunodeficiency virus (HIV) patients. Objective: This study was carried out to determine the prevalence of nephropathy and proximal tubule disorder in HIV patients under tenofovir therapy.
Foroogh Sabzghabaei +5 more
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Generation and characterization of an inducible renal proximal tubule-specific CreERT2 mouse
Frontiers in Cell and Developmental Biology, 2023 Protein reabsorption in renal proximal tubules is essential for maintaining nutrient homeostasis. Renal proximal tubule-specific gene knockout is a powerful method to assess the function of genes involved in renal proximal tubule protein reabsorption ...
Shiting Liang +7 more
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PLoS ONE, 2022 Metallothionein 3 (MT-3) is a small, cysteine-rich protein that binds to essential metals required for homeostasis, as well as to heavy metals that have the potential to exert toxic effects on cells.
Gazal Kalyan +8 more
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Communications Biology, 2023 Of late, numerous microphysiological systems have been employed to model the renal proximal tubule. Yet there is lack of research on refining the functions of the proximal tubule epithelial layer—selective filtration and reabsorption.
Ramin Banan Sadeghian +7 more
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