Results 21 to 30 of about 605,238 (303)
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance A single acute kidney injury event increases the risk of progression to chronic kidney disease (CKD). Combining single-nucleus RNA sequencing with genetic tracing of injured proximal tubule cells identified a spatially dynamic, evolving ...
Louisa M. S. Gerhardt +4 more
semanticscholar +1 more source
Prevalence of nephropathy and proximal tubule disorder in human immunodeficiency virus patients under tenofovir therapy [PDF]
Journal of Nephropharmacology, 2022 Introduction: Tenofovir is a common therapy in human immunodeficiency virus (HIV) patients. Objective: This study was carried out to determine the prevalence of nephropathy and proximal tubule disorder in HIV patients under tenofovir therapy.
Foroogh Sabzghabaei +5 more
doaj +1 more source
Comparative Analysis of Proximal Tubule Cell Sources for In Vitro Studies of Renal Proximal Tubule Toxicity. [PDF]
BiomedicinesBackground/Objectives: The kidneys are essential for eliminating drugs and chemicals from the human body and renal epithelial cells are particularly vulnerable to damage caused by xenobiotics and their metabolites. Drug-induced kidney toxicity is a major
Sakolish C +10 more
europepmc +2 more sources
PLoS ONE, 2022 Metallothionein 3 (MT-3) is a small, cysteine-rich protein that binds to essential metals required for homeostasis, as well as to heavy metals that have the potential to exert toxic effects on cells.
Gazal Kalyan +8 more
doaj +2 more sources
Communications Biology, 2023 Of late, numerous microphysiological systems have been employed to model the renal proximal tubule. Yet there is lack of research on refining the functions of the proximal tubule epithelial layer—selective filtration and reabsorption.
Ramin Banan Sadeghian +7 more
doaj +1 more source
Micromachines, 2021 Kidney microphysiological systems (MPS) serve as potentially valuable preclinical instruments in probing mechanisms of renal clearance and osmoregulation. Current kidney MPS models target regions of the nephron, such as the glomerulus and proximal tubule
Stephanie Y. Zhang, Gretchen J. Mahler
doaj +1 more source
Far infrared radiation promotes rabbit renal proximal tubule cell proliferation and functional characteristics, and protects against cisplatin-induced nephrotoxicity. [PDF]
PLoS ONE, 2017 Far infrared radiation, a subdivision of the electromagnetic spectrum, is beneficial for long-term tissue healing, anti-inflammatory effects, growth promotion, sleep modulation, acceleration of microcirculation, and pain relief.
I-Ni Chiang +3 more
doaj +1 more source
YAP Activation in Renal Proximal Tubule Cells Drives Diabetic Renal Interstitial Fibrogenesis
Diabetes, 2020 An increasing number of studies suggest that the renal proximal tubule is a site of injury in diabetic nephropathy (DN), and progressive renal tubulointerstitial fibrosis is an important mediator of progressive kidney dysfunction in DN. In this study, we
Jianchun Chen +6 more
semanticscholar +1 more source
Functional Evaluation and Nephrotoxicity Assessment of Human Renal Proximal Tubule Cells on a Chip
Biosensors, 2022 An in vitro human renal proximal tubule model that represents the proper transporter expression and pronounced epithelial polarization is necessary for the accurate prediction of nephrotoxicity. Here, we constructed a high-throughput human renal proximal
Bolin Jing +5 more
doaj +1 more source
Cells, 2022 Diabetic kidney disease (DKD) remains the leading cause of end-stage kidney disease despite decades of study. Alterations in the glomerulus and kidney tubules both contribute to the pathogenesis of DKD although the majority of investigative efforts have ...
Kimberly S. Collins +14 more
doaj +1 more source