Results 21 to 30 of about 54,422 (163)
Adefovir-induced Fanconi syndrome associated with osteomalacia [PDF]
Clinical and Molecular Hepatology, 2018 Fanconi syndrome is a dysfunction of the proximal renal tubules that results in impaired reabsorption and increased urinary loss of phosphate and other solutes. The pathophysiology of drug-induced Fanconi syndrome is unclear. Here we report the case of a
Samel Park +10 more
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Bioengineered Cystinotic Kidney Tubules Recapitulate a Nephropathic Phenotype
Cells, 2022 Nephropathic cystinosis is a rare and severe disease caused by disruptions in the CTNS gene. Cystinosis is characterized by lysosomal cystine accumulation, vesicle trafficking impairment, oxidative stress, and apoptosis. Additionally, cystinotic patients
Elena Sendino Garví +2 more
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Ontogeny of proximal tubule acidification
Kidney International, 1995 The proximal tubule is responsible for the reabsorption of 80% of the filtered load of bicarbonate in adults. Proximal tubule bicarbonate reabsorption is affected by a number of hormones, acid-base balance, and the extracellular fluid volume status [1]. The adult proximal tubule thus plays a central role in acid-base homeostasis.
Baum, Michel, Quigley, Raymond
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Frontiers in Physiology, 2022 The sodium (Na+)/hydrogen (H+) exchanger 3 (NHE3) is one of the most important Na+/H+ antiporters in the small intestines of the gastrointestinal tract and the proximal tubules of the kidney.
Sarah M. Nwia +9 more
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The Proximal Tubule in Cystinosis [PDF]
Journal of the American Society of Nephrology, 2014 Although rare, nephropathic cystinosis is a devastating monogenic disorder leading to renal failure in the second decade of life. Fanconi syndrome, the initial renal manifestation of cystinosis in the young child, established the proximal tubule as a primary target of injury now recognized as ...
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Receptor-Mediated Endocytosis in the Proximal Tubule [PDF]
Annual Review of Physiology, 2017 Cells lining the proximal tubule (PT) of the kidney are highly specialized for apical endocytosis of filtered proteins and small bioactive molecules from the glomerular ultrafiltrate to maintain essentially protein-free urine. Compromise of this pathway results in low molecular weight (LMW) proteinuria that can progress to end-stage kidney disease ...
Megan L, Eshbach, Ora A, Weisz
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Journal of Diabetes Research, 2018 The kidney is an insulin-sensitive organ involved in glucose homeostasis. One major effect of insulin is to induce glycogen storage in the liver and muscle.
Romina Bertinat +7 more
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Ontogeny of NHE8 in the rat proximal tubule [PDF]
American Journal of Physiology-Renal Physiology, 2007 Proximal tubule bicarbonate reabsorption is primarily mediated via the Na+/H+ exchanger, identified as NHE3 in adults. Previous studies have demonstrated a maturational increase in rat proximal tubule NHE3 expression, with a paucity of NHE3 expression in neonates, despite significant Na+-dependent proton secretion. Recently, a novel Na+/H+ antiporter (
Amy M, Becker +6 more
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Renal Impairment of Proximal Tubular Injury Caused by Red Yeast Rice Supplement: Report of 2 Cases
Case Reports in Nephrology and DialysisIntroduction: Drug-induced tubulointerstitial injury is a common cause of renal impairment. Since the mechanisms of drug-induced tubular injury are diverse, various treatment approaches are needed according to the pathogenesis.
Kazuhiro Takeuchi +12 more
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Journal of Islamic International Medical College, 2021 Objective: To determine the potential adverse renal histopathological effects on the proximal convoluted tubules in male, Wistar rats due to ingestion of subchronic dose of triazophos. Study Design: Randomized controlled trial.
Lubna Shahper , Shagufta Nasreen , Muhammad Qasim Muneer , Nazia Ayyub , Sadia Hassan
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