Results 141 to 150 of about 6,958 (184)

Prion protein (PrPc) promotes β-amyloid plaque formation

Neurobiology of Aging, 2005
Prion protein (PrP) has been localized to amyloid-beta (Abeta) senile plaques in aging and Alzheimer disease, but it is unknown whether PrP is directly involved in plaque formation or represents a reaction to amyloid deposition. To evaluate possible functional effects of PrP in Abeta plaque formation, we analyzed bigenic mice (TgCRND8/Tg7), carrying ...
Katja, Schwarze-Eicker, Kathy, Keyvani, Nicole, Görtz, David, Westaway, Norbert, Sachser, Werner, Paulus   +5 more
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Mitochondrial localization of cellular prion protein (PrPC) invokes neuronal apoptosis in aged transgenic mice overexpressing PrPC

Neuroscience Letters, 2005
Recent studies suggest that the disease isoform of prion protein (PrPSc) is non-neurotoxic in the absence of cellular isoform of prion protein (PrPC), indicating that PrPC may participate directly in the neurodegenerative damage by itself. Meanwhile, transgenic mice harboring a high-copy-number of wild-type mouse (Mo) PrPC develop a spontaneous ...
Naomi S, Hachiya, Makiko, Yamada, Kota, Watanabe, Akiko, Jozuka, Takuya, Ohkubo, Kenichi, Sano, Yoshio, Takeuchi, Yoshimichi, Kozuka, Yuji, Sakasegawa, Kiyotoshi, Kaneko   +9 more
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Isolation and characterization of full-length recombinant cattle PrPC protein

Bulletin of Experimental Biology and Medicine, 2006
Full-length Bos taurus PrPC protein was obtained in the eu- and prokaryotic expression systems. Immunoblotting and indirect enzyme immunoassay demonstrated high specificity and antigenic activity of full-length proteins in the reactions with monoclonal antibodies (anti-SAF-32 and VRQ-84).
S L, Kal'nov, V B, Grigor'ev, K P, Alekseev, A N, Vlasova, R A, Gibadulin, A N, Pokidyshev, M V, Balandina, V V, Tsibezov, O A, Verkhovskii   +8 more
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Ultrastructural localization of cellular prion protein (PrPc) at the neuromuscular junction

Journal of Neuroscience Research, 1999
We examined the localization of the normal cellular isoform of prion protein (PrPc) in mammalian skeletal muscle. Using two anti-PrP antibodies, the neuromuscular junction (NMJ) was preferentially stained after immunohistofluorescence. The mouse, hamster, and human NMJ displayed a fluorescent signal specific for PrPc.
Gohel, C., Grigoriev, V., Escaig-Haye, F., Lasmezas, C.I., Deslys, J.P., Langeveld, J., Akaaboune, M., Hantai, D., Fournier, J.G.   +8 more
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Platelet Cellular Prion Protein (PRPC) Is Associated with alpha Granules.

Blood, 2004
Abstract The cellular prion protein (PrPc) is a membrane glycoprotein expressed on many human cells including blood platelets. We have previously shown that human platelets rapidly up-regulate PrPc on their plasma membranes after activation (Holada et al., Br J Haematol.1998;103(1):276–82.).
Karel Holada, Adela Brouckova, Jan Simak, William A. Gahl, Jaroslav G. Vostal   +4 more
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Polymorphism In The PrPC Prion Protein Gene In Pigs

2023
Protein coding regions of the PrPC gene in 51 pigs belonging to 3 breeds namely Hampshire, Yorkshire, Blue Butt Cross (blue spotted cross from a Hampshire X Yorkshire), and a wild pig were studied. These breeds are used nationwide for commercial purposes. The PrPC gene of the pigs that code for prion proteins were sequenced and studied.
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Preliminary results of human PrPC protein studied by spectroscopic techniques

Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 2017
Abstract Neurodegenerative diseases are one of the malfunctions of human nervous system, being a class of complex and prominent pathologies. The human prion Protease Resistant Protein (PrP) is protein regulating copper metabolism in mammalian cells through binding of Cu(II) ions to specific fragments. Nowadays misfolding of this protein is associated
Michał Nowakowski, Joanna Czapla-Masztafiak, Maciej Kozak, Igor Zhukov, Lilia Zhukova, Jakub Szlachetko, Wojciech M. Kwiatek   +6 more
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[Functions of prion protein PrPc].

Medecine sciences : M/S, 2007
It is now well established that both normal and pathological (or scrapie) isoforms of prion protein, PrPc and PrPsc respectively, are involved in the development and progression of various forms of neurodegenerative diseases, including scrapie in sheep, bovine spongiform encephalopathy (or "mad cow disease") and Creutzfeldt-Jakob disease in human ...
Sylvie, Cazaubon, Pedro, Viegas, Pierre-Olivier, Couraud   +2 more
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Distribution and submicroscopic immunogold localization of cellular prion protein (PrPc) in extracerebral tissues

Cell and Tissue Research, 1998
In transmissible spongiform encephalopathies (TSE), such as scrapie in animals and Creutzfeldt-Jakob disease in humans, the central event is the conversion of a host-encoded amyloidogenic protein (PrPc) into an abnormal isoform (PrPsc) that accumulates as amyloid in TSE brain.
J G, Fournier, F, Escaig-Haye, T, Billette de Villemeur, O, Robain, C I, Lasmézas, J P, Deslys, D, Dormont, P, Brown   +7 more
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Expression of Cellular Prion Protein (PrPc) on Human Red Blood Cells.

Blood, 2005
Abstract Two recent UK cases of vCJD transmission by blood transfusion emphasize urgent need of donor screening test for prion diseases. Pathological form of prion protein, PrPsc, is currently the only specific marker of prion diseases, but its detection in blood poses significant challenge.
Martin Panigaj, Adela Brouckova, Hana Glierova, Karel Holada   +3 more
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