Results 31 to 40 of about 5,869 (184)
Change in the characteristics of ferritin induces iron imbalance in prion disease affected brains
Neurobiology of Disease, 2012 Prion disease associated neurotoxicity is mainly attributed to PrP-scrapie (PrPSc), the disease associated isoform of a normal protein, the prion protein (PrPC).
Ajay Singh +3 more
doaj +1 more source
Prion acute synaptotoxicity is largely driven by protease-resistant PrPSc species. [PDF]
PLoS Pathogens, 2018 Although misfolding of normal prion protein (PrPC) into abnormal conformers (PrPSc) is critical for prion disease pathogenesis our current understanding of the underlying molecular pathophysiology is rudimentary. Exploiting an electrophysiology paradigm,
Simote Totauhelotu Foliaki +11 more
doaj +1 more source
Early Generation of New PrPSc on Blood Vessels after Brain Microinjection of Scrapie in Mice
mBio, 2015 Aggregation of misfolded host proteins in the central nervous system is believed to be important in the pathogenic process in several neurodegenerative diseases of humans, including prion diseases, Alzheimer's disease, and Parkinson's disease.
Bruce Chesebro +6 more
doaj +1 more source
Creutzfeldt-Jakob Disease, Prion Protein Gene Codon 129VV, and a Novel PrPSc Type in a Young British Woman [PDF]
Archives of Neurology, 2007 Variant Creutzfeldt-Jakob disease (vCJD) is an acquired prion disease causally related to bovine spongiform encephalopathy that has occurred predominantly in young adults. All clinical cases studied have been methionine homozygotes at codon 129 of the prion protein gene (PRNP) with distinctive neuropathological findings and molecular strain type (PrP ...
Simon, Mead +7 more
openaire +2 more sources
Pharmacological Agents Targeting the Cellular Prion Protein
Pathogens, 2018 Prion diseases are associated with the conversion of the cellular prion protein (PrPC), a glycoprotein expressed at the surface of a wide variety of cell types, into a misfolded conformer (the scrapie form of PrP, or PrPSc) that accumulates in brain ...
Maria Letizia Barreca +4 more
doaj +1 more source
Human Prion Protein (PrP) 219K Is Converted to PrPSc but Shows Heterozygous Inhibition in Variant Creutzfeldt-Jakob Disease Infection [PDF]
Journal of Biological Chemistry, 2009 Prion protein gene (PRNP) E219K is a human polymorphism commonly occurring in Asian populations but is rarely found in patients with sporadic Creutzfeldt-Jakob disease (CJD). Thus the polymorphism E219K has been considered protective against sporadic CJD. The corresponding mouse prion protein (PrP) polymorphism variant (mouse PrP 218K) is not converted
Masaki, Hizume +6 more
openaire +2 more sources
Detecting a psoriatic antigen analogous to infectious prion proteins
Инфекция и иммунитет, 2019 Until now, psoriatic antigen as a specific antigen derived from some infectious agent potentially related to origin of psoriasis has not been identified, thereby strongly arguing against infectious theory of psoriasis.
B. F. Sinitsyn
doaj +1 more source
Frontiers in Cellular Neuroscience, 2021 Amyloid-based neurodegenerative diseases such as prion, Alzheimer's, and Parkinson's diseases have distinct etiologies and clinical manifestations, but they share common pathological events.
Benoit Schneider +17 more
doaj +1 more source
INTERRELATION OF PRIONS WITH NON-CODING RNAS
Вавиловский журнал генетики и селекции, 2018 Prions are alternative infectious conformations for some cellular proteins. For the protein PrPC (PrP – prion protein, С – common), a prion conformation, called PrPSc (S – scrapie), is pathological.
R. N. Mustafin, E. K. Khusnutdinova
doaj +1 more source
Post-translational modifications in prion diseases
Frontiers in Molecular NeuroscienceMore than 650 reversible and irreversible post-translational modifications (PTMs) of proteins have been listed so far. Canonical PTMs of proteins consist of the covalent addition of functional or chemical groups on target backbone amino-acids or the ...
Chloé Bizingre +12 more
doaj +1 more source