Results 61 to 70 of about 1,549,882 (213)

Proteins

, 2004
Solvation energy calculation is one of the main difficulties for the estimation of protein-ligand binding free energy and the correct scoring in docking studies.
Zhou, JJ, Wang, Q, Pei, JF, Lai, LH
core   +1 more source

The 37kDa/67kDa laminin receptor as a therapeutic target in prion diseases: potency of antisense LRP RNA, siRNAs specific for LRP mRNA and a LRP decoy mutant [PDF]

, 2006
Prion diseases are a group of rare, fatal neurodegenerative diseases, also known as transmissible spongiform encephalopathies (TSEs), that affect both animals and humans and include bovine spongiform encephalopathy (BSE) in cattle, scrapie in sheep ...
Vana, Karen
core   +1 more source

Soluble polymorphic bank vole prion proteins induced by co-expression of quiescin sulfhydryl oxidase in E. coli and their aggregation behaviors

Microbial Cell Factories, 2017
Background The infectious prion protein (PrPSc or prion) is derived from its cellular form (PrPC) through a conformational transition in animal and human prion diseases.
Romany Abskharon, Johnny Dang, Ameer Elfarash, Zerui Wang, Pingping Shen, Lewis S. Zou, Sedky Hassan, Fei Wang, Hisashi Fujioka, Jan Steyaert, Mentor Mulaj, Witold K. Surewicz, Joaquín Castilla, Alexandre Wohlkonig, Wen-Quan Zou   +14 more
doaj   +1 more source

HaloTag Fusion Enables Dynamic Analysis of Prion Protein Biosynthesis, Turnover, and Misfolding

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
Prion protein (PrP) misfolding underlies fatal neurodegenerative diseases. We developed a HaloTag‐based PrP fusion enabling spatiotemporal labeling of distinct PrP populations in living cells. This system recapitulates native PrP biology, reveals early misfolding events in disease‐associated mutants, and allows mechanistic interrogation of PrP‐lowering
Antonio Masone, Eleonora Busani, Roberto Chiesa   +2 more
wiley   +1 more source

NUAK2 Inhibition Enhances Macromolecular Drug Delivery in a 3D Fibrotic Model of the Pancreatic Tumor Microenvironment

Advanced NanoBiomed Research, Volume 6, Issue 6, June 2026.
Using a 3D cell culture model of the fibrotic barrier in pancreatic cancer, this work shows that inhibiting NUAK2 kinase in pancreatic stellate cells enhances macromolecular drug delivery. Mechanistically, NUAK2 inhibition disrupted actin stress fiber assembly to downregulate collagen I expression, thus enhancing macromolecular permeability.
Misaki Nakamura, Hiroyoshi Y. Tanaka, Mayu Ohira, Haruko Ohta‐Okano, Reika Nakamura, Yu Seno, Saaya Yara, Sakura Fujita, Daichi Shibata, Masaya Yamamoto, Shinichi Toyooka, Kensuke Osada, Horacio Cabral, Atsushi Masamune, Mitsunobu R. Kano   +14 more
wiley   +1 more source

Exploring the mechanisms involved in prion degradation and spreading from cell-to-cell in neuronal cell models [PDF]

, 2011
Transmissible spongiform encephalopathies (TSE), also known as prion diseases, are fatal neurodegenerative disorders present both in human and animals with different aetiology as they can occur genetically, spontaneously or by infection (Prusiner 1998 ...
Marzo, Ludovica
core   +1 more source

Proteins as markers of TSE infection in sheep blood

, 2008
Transmissible spongiform encephalopathies (TSEs) are a group of fatal infectious neurodegenerative diseases affecting both humans and agricultural animals. TSE transmission via blood transfusion has been demonstrated experimentally in rodent, primate and
Martin, Joanne
core   +1 more source

DL‐3‐n‐Butylphthalide Protects Against PrP106−126‐Induced Neurotoxicity Through NRF2 Signaling and OPA1/DRP1‐Mediated Mitochondrial Dynamics

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
NBP counteracts PrP106‐126‐induced neurotoxicity by activating NRF2 and restoring OPA1/DRP1‐mediated mitochondrial dynamics. It suppresses oxidative stress and preserves mitochondrial function and bioenergetics. These actions support NBP as a promising therapeutic candidate for prion‐related neurodegeneration.
Wei Wu, Xixi Zhang, Mingyue Jiang, Ning Ma   +3 more
wiley   +1 more source

Discrimination of Classical and Atypical BSE by a Distinct Immunohistochemical PrPSc Profile

, 2023
<p>Bovine spongiform encephalopathy (BSE) is a fatal neurodegenerative disease in cattle belonging to the group of transmissible spongiform encephalopathies.
Graham, Catherine, Fast, Christine, Groschup, Martin H., Czub, Stefanie, Kaatz, Tammy, MacPherson, Kendra, Ziegler, Ute, Santiago-Mateo, Kristina, Balkema-Buschmann, Anne, Kaatz, Martin   +9 more
core   +1 more source

Tracking and clarifying differential traits of classical- and atypical L-type bovine spongiform encephalopathy prions after transmission from cattle to cynomolgus monkeys.

PLoS ONE, 2019
Classical- (C-) and atypical L-type bovine spongiform encephalopathy (BSE) prions cause different pathological phenotypes in cattle brains, and the disease-associated forms of each prion protein (PrPSc) has a dissimilar biochemical signature.
Ken'ichi Hagiwara, Yuko Sato, Yoshio Yamakawa, Hideyuki Hara, Minoru Tobiume, Yuko Okemoto-Nakamura, Tetsutaro Sata, Motohiro Horiuchi, Hiroaki Shibata, Fumiko Ono   +9 more
doaj   +1 more source