Results 31 to 40 of about 47,105 (312)

Ionizable Lipid‐Dependent Optimization of Steroid Lipid Nanoparticles With Tunable Immunomodulatory Properties

Advanced Materials, EarlyView.
A novel engineering strategy that establishes material design principles for incorporating anti‐inflammatory steroids into lipid nanoparticles to reduce LNP‐induced inflammation while retaining mRNA delivery. Results are validated in vitro and in three animal models of inflammation and autoimmunity in vivo.
Ajay S. Thatte, Benjamin E. Nachod, Julia Baena, Jenna Muscat‐Rivera, Lesley Chaboub, Hannah C. Safford, Hannah C. Geisler, Hannah M. Yamagata, Melgious J. Y. Ang, Michael Kegel, Alexandre Poirier, Elaine R. Tong, Zhe Zhong, Qiangqiang Shi, Jinjin Wang, Elisa Battistini, Ye Zeng, Alex G. Hamilton, Kelsey L. Swingle, Drew Weissman, Jilian R. Melamed, Michael J. Mitchell   +21 more
wiley   +1 more source

Safety of glucagon-like peptide-1 agonists: data from the Russian National pharmacovigilance system

Реальная клиническая практика: данные и доказательства
Background. Glucagon-like peptide-1 (GLP-1) receptor agonists are widely used as pharmacotherapy for type 2 diabetes mellitus and obesity.Objective. This study aimed to characterize adverse reactions (ARs) and assess the disproportionality of reporting ...
Yu. M. Gomon, E. A. Medvenskaya, A. S. Kolbin, K. V. Gorelov   +3 more
doaj   +1 more source

PORCINE REPRODUCTIVE RESPIRATORY SINDROME (PRRS) [PDF]

, 2012
Respiratory disease in pigs are major cause of morbidity, mortality, and major cause of economic losses. As results of this situation, it is necessary to carry out timely diagnoses, adequate therapy and on farms established prophylactic measures. Our intention was to show in this paper, production indicators, such as consequence presence of PRRS in pig
Bojkovski, Jovan, Doborasvljević, Ivan, Delić, Nikola, Savić, Božidar, Rogožarski, Dragan, Petrujkić, Tihomir   +5 more
openaire   +4 more sources

Alcohol formative audience assessment comprehensive report

, 2021
Title from PDF cover (viewed on September 22, 2022).This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program.

core  

Processing‐Induced Performance Limits of Platinum Resistance Temperature Detectors for Reliable Organ‐On‐A‐Chip Sensing

Advanced Materials Interfaces, EarlyView.
The thermal budget imposed during oxide passivation is revealed as a key design parameter for Pt resistance temperature detectors in Organ‐on‐a‐Chip platforms. By establishing a direct processing–microstructure–device performance relationship, this work transforms an unavoidable fabrication step into a strategy for reliable integrated temperature ...
Gabriel M. Ferreira, Paulo J. Sousa, Susana O. Catarino, Graça Minas, Patrícia C. Sousa   +4 more
wiley   +1 more source

Sustainable development goals in tourism research

Discover Sustainability
Tourism has a significant impact on the society’s development. This study aims to analyze the integration of the sustainable development goals (SDGs) in various tourism areas through a bibliometric analysis and a systematic review of the literature ...
Alexandra Lavaredas, Filipa Campos, Giovana Goretti Feijó Almeida, Francisco Dias, Paulo Almeida   +4 more
doaj   +1 more source

Activation of (pro)renin by (pro)renin receptor in extracellular vesicles from osteoclasts

Scientific Reports, 2021
The (pro)renin receptor (PRR) is a multifunctional integral membrane protein that serves as a component of the vacuolar H+-ATPase (V-ATPase) and also activates (pro)renin.
Jonathan B. Murray, Christy Mikhael, Guanghong Han, Lorraine Perciliano de Faria, Wellington J. Rody, L. Shannon Holliday   +5 more
doaj   +1 more source

Deciphering the immunological and prognostic features of bladder cancer through platinum-resistance-related genes analysis and identifying potential therapeutic target P4HB

Frontiers in Immunology, 2023
ObjectivesTo identify the molecular subtypes and develop a scoring system for the tumor immune microenvironment (TIME) and prognostic features of bladder cancer (BLCA) based on the platinum-resistance-related (PRR) genes analysis while identifying P4HB ...
Situ Xiong, Situ Xiong, Sheng Li, Sheng Li, Jin Zeng, Jin Zeng, Jianqiang Nie, Jianqiang Nie, Taobin Liu, Taobin Liu, Xiaoqiang Liu, Luyao Chen, Bin Fu, Bin Fu, Jun Deng, Songhui Xu, Songhui Xu   +16 more
doaj   +1 more source

Dual Role of Tamoxifen in Enhancing STING and CEACAM1 Expression to Prime a Favorable Tumor Microenvironment for Anti‐TIM3 Immunotherapy

Advanced Science, EarlyView.
Anti‐PD‐1/PD‐L1 blockade has revolutionized cancer immunotherapy, but is ineffective against endocrine‐treated (i.e., Tamoxifen), relapsed ER+ breast cancer (BC) patients. This study provides insight into the sub‐optimal response of ER+BCs to anti‐PD‐1/PD‐L1 blockade – highlighting the induction of STING and the CEACAM1/TIM3 axis after chronic ...
Marvin Angelo E Aberin, Saurabh Singh, Soumya Chatterjee, Guang‐Zhi Sui, Yi‐Fu Wang, Ya‐Ting Lu, Yu‐Ling Lee, Kun‐Yuan Lin, Joy Khag, Ta‐Yu Liu, Shao‐Han Chang, Wai‐Mui Cheung, Hsiao‐Chin Hong, Ren‐Jun Hsu, Chen‐Yang Shen, Chia‐Wei Li, Weng‐Lang Yang, Yao‐Ming Chang, Shih‐Yu Chen, Chandan Guha, Shu‐Ping Wang   +20 more
wiley   +1 more source

ATP6AP2 is Overexpressed in Breast Cancer and Promotes Breast Cancer Progression

Cancer Management and Research, 2020
Kankan Zhao,* Mengchuan Wang,* Aiguo Wu Department of General Surgery, Zhujiang Hospital, The Second School of Clinical Medicine, Southern Medical University, Guangzhou 510282, People’s Republic of China*These authors contributed equally to this ...
Zhao K, Wang M, Wu A
doaj