Results 111 to 120 of about 9,785 (151)

JAK2 V617F MUTATION AND PRV-1 OVEREXPRESSION: RELEVANCE IN THE DIAGNOSIS OF POLYCYTHAEMIA VERA AND ESSENTIAL THROMBOCYTHAEMIA

Acta Clinica Belgica, 2009
In the diagnosis of polycythaemia vera and essential thrombocythaemia, two molecular markers were described in the last decade: the overexpression of the PRV-1 gene and the V617F mutation in the JAK2 gene. In this study we assess their usefulness by comparing our test results with the available clinical data.
S, Melis, S, Vellinga, P, Zachée, A C, Sierens, P J J C, De Schouwer   +4 more
openaire   +2 more sources

The Jak2V617F mutation, PRV-1 overexpression, and EEC formation define a similar cohort of MPD patients

Blood, 2005
AbstractRecently, a Jak2V617F mutation has been described in the vast majority of patients with polycythemia vera (PV) as well as in subsets of patients with essential thrombocythemia (ET) and idiopathic myelofibrosis (IMF). The question arises whether this mutation is observed in those patients with ET and IMF who have also displayed previously ...
Philipp S, Goerttler, Cordula, Steimle, Edith, März, Peter L, Johansson, Björn, Andreasson, Martin, Griesshammer, Heinz, Gisslinger, Hermann, Heimpel, Heike L, Pahl   +8 more
openaire   +3 more sources

PRV-1 Interacts with the Cytoplasmic Domain of Mpl and Interferes with TPO-Induced Signaling Cascades.

Blood, 2006
Abstract Polycythemia rubra vera-1 (PRV-1) is a member of the uPAR/CD59/Ly6 family of cell surface receptors. An increase in the expression level of PRV-1 mRNA has been shown in patients with polycythemia vera and essential thrombocythemia, however, the ligand and function of PRV-1 remains unclear.
Brian J. Lannutti, Jennifer N. Minear, Manish Ghandi, Jan Johnson   +3 more
openaire   +1 more source

Increased Expression of the PRV-1 Gene in Thalassemia Reflects the Rate of the Underlying Erythropoietic Activity.

Blood, 2005
Abstract Over the last years, PRV-1 expression has been considered to be closely connected with polycythemia vera (PV). However, the precise function of the PRV-1 protein has never been clarified while the search for the pathogenetic mechanism of PV has shifted to the association between the PRV-1 gene and the JAK2 V617F mutation rather ...
Dimitris Loukopoulos, Evangelos Terpos, Ersi Voskaridou, Christine Zoi, Katerina Zoi   +4 more
openaire   +1 more source

Clinical Utility of PRV-1 mRNA Expression Levels in Polycythemia Vera and Essential Thrombocythemia.

Blood, 2012
Abstract Abstract 2846 Background: PRV-1 mRNA is overexpressed in most patients with polycythemia vera (PV) and a part of patients with essential thrombocythemia (ET). It is well known that PRV-1 expression levels correlate with JAK2 V617F mutation. While it was reported that JAK2 V617F
Hung Chang, Yu-Shin Hung, Chia-Hui Chang, Yu-Hui Huang, Tung-Liang Lin, Tung-Huei Lin, Po Dunn, Jin-Hou Wu, Po-Nan Wang, Ming-Chung Kuo, Tzung-Chih Tang, Lee-Yung Shih   +11 more
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Cloning of PRV-1, a novel member of the uPAR receptor superfamily, which is overexpressed in polycythemia rubra vera

Blood, 2000
AbstractPolycythemia vera (PV) is a clonal stem cell disorder characterized by hyperproliferation of the erythroid, myeloid, and megakaryocytic lineages. Although it has been shown that progenitor cells of patients with PV are hypersensitive to several growth factors, the molecular pathogenesis of this disease remains unknown.
Temerinac, Snezana, Klippel, Steffen, Strunck, Elisabeth, Roder, S., Lübbert, Michael, Lange, Winand, Azémar, Marc, Meinhardt, Gerold, Schaefer, H. Martin, Pahl, Heike-L.   +9 more
openaire   +2 more sources

Usefulness of the quantitative assessment of PRV-1 gene expression for the diagnosis of polycythemia vera and essential thrombocythemia patients

Blood, 2004
In a recent article in this journal, Klippel et al[1][1] reported that overexpression of the polycythemia rubra vera 1 gene (PRV-1) in purified granulocytes can distinguish patients with polycythemia vera (PV) from those with secondary erythrocytosis (SE) and from healthy subjects.
Daniela, Cilloni, Sonia, Carturan, Enrico, Gottardi, Francesca, Messa, Milena, Fava, Ilaria, Defilippi, Francesca, Arruga, Giuseppe, Saglio   +7 more
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Clinical and Laboratory Correlative Studies of Neutrophil PRV-1 Expression: A Prospective Study in 141 Subjects.

Blood, 2004
Abstract Background : Controversy persists regarding diagnostic accuracy as well as added value for quantitative assessment of neutrophil PRV-1 expression in polycythemia vera (Klippel et al. Blood2003;102:3569; Tefferi et al. Blood2004;103:3547).
Shireen Sirhan, Terra L. Lasho, Ayalew Tefferi   +2 more
openaire   +1 more source

Neutrophil PRV-1 mRNA Overexpression in Chronic Idiopathic Myelofibrosis May Be Associated with Poor Prognosis.

Blood, 2004
Abstract Neutrophil PRV-1 mRNA is overexpressed in nearly all patients with polycythemia vera (PV) and discriminates PV from secondary polycythemia. In addition, 40– 50% of patients with essential thrombocythemia (ET) and chronic idiopathic myelofibrosis (cIMF) overexpress PRV-1.
Heike L. Pahl, Juergen Thiele, Alexandra Kaider, Mathias Kees, Hermann Heimpel, Steffen Klippel, Heinz Gisslinger   +6 more
openaire   +1 more source

Biomarker analysis in polycythemia vera under interferon-alpha treatment: clonality, EEC, PRV-1, and JAK2 V617F

Annals of Hematology, 2007
Three consecutive polycythemia vera (PV) patients were analyzed before and during pegylated-interferon (rIFNalpha) treatment for the following markers: (1) granulocyte and CD34(+) cell clonality, (2) Jak2V617F expression, (3) PRV-1 mRNA overexpression, and (4) Epo-independent colony (EEC) growth.
Steimle, Cordula, Lehmann, Ulrich, Temerinac, Snezana, Goerttler, Philipp, Kreipe, Hans, Meinhardt, Gerold, Heimpel, Hermann, Pahl, Heike-L.   +7 more
openaire   +3 more sources