Results 121 to 130 of about 9,785 (151)

A new real-time RT-PCR for the detection of piscine orthoreoviruses PRV-1 and PRV-3

Journal of Virological Methods
Piscine orthoreoviruses (PRV) are often associated with pathologies affecting various salmonid species, especially farmed species. Both surveillance and research purposes require diagnostic molecular-based tools able to detect the most frequent genotypes, namely PRV-1 and PRV-3.
Laurane, Pallandre, Marine, Baud, Emma, Rolland, Alexiane, Talbodec, Laurent, Bigarré   +4 more
openaire   +2 more sources

Biochemical characterization of PRV-1, a novel hematopoietic cell surface receptor, which is overexpressed in polycythemia rubra vera

Blood, 2002
The cDNA for polycythemia rubra vera 1 (PRV-1), a novel hematopoietic receptor, was recently cloned by virtue of its overexpression in patients with polycythemia vera. PRV-1 is a member of the uPAR/CD59/Ly6 family of cell surface receptors, which share a common cysteine-rich domain and are tethered to the cell surface via a glycosylphosphatidylinositol
Steffen, Klippel, Elisabeth, Strunck, Christian E, Busse, Dirk, Behringer, Heike L, Pahl   +4 more
openaire   +3 more sources

Detection of abnormalities of PRV-1, TPO, and c-MPL genes detected by fluorescence in situ hybridization in essential thrombocythemia

Cancer Genetics and Cytogenetics, 2006
No specific diagnostic markers have been described in essential thrombocythemia (ET). PRV-1 (polycythemia rubra vera-1), TPO (thrombopoietin), and c-MPL (myeloproliferative leukemia virus oncogene) genes are candidate ET molecular markers because of their implication in the pathogenesis of ET.
Eulàlia, Puigdecanet, Blanca, Espinet, Olaya, Villa, Lourdes, Florensa, Carles, Besses, Sergi, Serrano, Francesc, Solé   +6 more
openaire   +2 more sources

The Clinical and PRV-1 Expression Phenotype of Wild-Type, Heterozygous, and Homozygous JAK2 V617F in Polycythemia Vera.

Blood, 2005
Abstract BACKGROUND. Several studies have recently reported on the occurrence of a JAK2 V617F mutation in myeloid cells from the majority of patients with polycythemia vera (PV). The clinical relevance of this novel observation is currently under study.
D. Gary Gilliland, Stephanie J. Lee, Martha Wadleigh, Chin Yang Li, David P. Steensma, Alexandra P. Wolanskyj, Ruben A. Mesa, Michelle A. Elliott, Jacob S. Strand, Susan M. Schwager, Terra L. Lasho, Shireen Sirhan, Ayalew Tefferi   +12 more
openaire   +1 more source

Quantification of intrahost genetic diversity of Piscine Orthoreovirus (PRV-1) infecting Atlantic and Chinook salmon

2022
The decline in populations of wild Pacific salmon is of great concern given their importance to Indigenous Peoples of Canada, Pacific Northwest ecosystems, and commercial fisheries. Contagious diseases may contribute to these losses. Piscine orthoreovirus 1 (PRV-1) is a pathogen recently linked to Heart and Skeletal Muscle Inflammation (HSMI) in farmed
openaire   +1 more source

Inconsistencies in the association between the JAK2^V617F mutation and PRV‐1 over‐expression among the chronic myeloproliferative diseases

British Journal of Haematology, 2006
Inconsistencies in the association between the JAK2(V617F) mutation and PRV-1 over-expression among the chronic myeloproliferative diseases.
VANNUCCHI, ALESSANDRO MARIA, GUGLIELMELLI, PAOLA, ANTONIOLI, ELISABETTA, MAPPA, SILVIA, PANCRAZZI, ALESSANDRO, BOGANI, COSTANZA, PONZIANI, VANESSA, BOSI, ALBERTO   +7 more
openaire   +2 more sources

The presence of a significant association between elevated PRV‐1 mRNA expression and low plasma erythropoietin concentration in essential thrombocythaemia

European Journal of Haematology, 2003
Abstract:Approximately 45% of newly diagnosed patients with essential thrombocythaemia (ET) demonstrate subnormal plasma erythropoietin (EPO) concentrations, which constitutes a risk factor for occlusive vascular events. In 58 ET patients, a possible association between polycythaemia rubra vera‐1 (PRV‐1) overexpression and subnormal plasma EPO was ...
Peter, Johansson, Björn, Andréasson, Soodabeh, Safai-Kutti, Lovisa, Wennström, Lars, Palmqvist, Anne, Ricksten, Göran, Lindstedt, Jack, Kutti   +7 more
openaire   +2 more sources

Expression of the GPI-anchored receptor Prv-1 enhances thrombopoietin and IL-3-induced proliferation in hematopoietic cell lines

Leukemia Research, 2008
Prv-1 is a hematopoietic cell surface receptor that has been shown to be overexpressed in patients diagnosed with polycythemia vera (PV) and essential thrombocythemia (ET), yet its cellular function remains unclear. In this study, we assessed the role of Prv-1 in thrombopoietin (Tpo)/Mpl signaling with the goal of identifying molecular mechanisms which
Megan, Dillon, Jennifer, Minear, Jan, Johnson, Brian J, Lannutti   +3 more
openaire   +2 more sources

[New molecular markers within the chronic myeloproliferative disorders. I: the PRV-1 gene].

Ugeskrift for laeger, 2006
PRV-1 is a new molecular marker within the Ph-negative chronic myeloproliferative disorders. PRV-1 is a useful, highly sensitive and specific marker in the differentiation between polycythaemia vera (PV) and secondary erythrocytosis (ET), and seems to identify those PV patients presenting in the early phase of the disease with dominating thrombocytosis
Thomas Stauffer, Larsen, Niels, Pallisgaard, Jacob Haaber, Christensen, Paul, Gram-Hansen, Gitte B, Kerndrup, Michael Boe, Møller, Hans Carl, Hasselbalch   +6 more
openaire   +1 more source

PRV-1 mRNA expression and other molecular markers in polycythemia rubra vera.

Current hematology reports, 2003
During the past 4 years, the first molecular markers for polycythemia vera (PV) have been described. These markers include decreased expression of the thrombopoietin receptor c-Mpl, increased expression of the surface receptor polycythemia rubra vera-I, and insulin-like growth factor-I hypersensitivity.
openaire   +1 more source