Results 91 to 100 of about 2,565,077 (232)

Antigen‐Detected NMR for Minimal Epitope Engineering and Structure‐Guided Selection of a NaV1.7‐Selective Nanobody

Advanced Science, EarlyView.
A minimal extracellular epitope from voltage‐gated sodium channel NaV1.7 was engineered into an isotope‐labelled antigen for antigen‐detected nuclear magnetic resonance (NMR). Together with AlphaFold2 (AF2), this enabled structure‐guided selection of R4C8, a human NaV1.7‐selective nanobody that labels fixed NaV1.7‐expressing cells and produces staining
Junyu Liu, Wanlin Chen, Ben Cristofori‐Armstrong, Theo Crawford, Kai‐En Chen, Peng Xie, Rainbow Wing Bo Chan, Yifei Zhu, Mimi Golder, Anneka Pereira Schmidt, Jennifer D. Naughton, Nicholas D. Condon, Åsa Andersson, Farhad Dehkhoda, Kirsten L. McMahon, Tabea Klasfauseweh, Ashvriya Thapa, Hue Tran, Poanna Tran, Sina Jami, Lotten Ragnarsson, Sebastian G. B. Furness, Jennifer R. Deuis, Brett M. Collins, Wai‐Hong Tham, Indira Prasadam, Irina Vetter, Mehdi Mobli   +27 more
wiley   +1 more source

Bottlebrush Polyolefin Sulfones as Triggerable and Degradable Pressure‐Sensitive Adhesives

Angewandte Chemie, EarlyView.
A grafting‐through alternating copolymerization strategy yields poly(norbornene sulfone) bottlebrush polymers with high molar mass. These materials function as additive‐free pressure‐sensitive adhesives. The incorporation of cleavable sulfone units enables rapid breakdown under mild alkaline conditions, providing a pathway toward sustainable, high ...
Clark Vu, Isaac D. Addo, Woojung Ham, Udita Choudhury, Joshua C. Worch, John B. Matson   +5 more
wiley   +2 more sources

Serum lipid metabolism in psoriasis and psoriatic arthritis – an update

Archives of Medical Science, 2019
Introduction Psoriasis and psoriatic arthritis (PSA) are chronic, inflammatory, systemic diseases characterized by metabolic abnormalities, including an increased cardiovascular risk and an oxidative imbalance.
Aldona Pietrzak, Paweł Chabros, Ewelina Grywalska, Paweł Kiciński, Kinga Franciszkiewicz-Pietrzak, Dorota Krasowska, Grzegorz Kandzierski   +6 more
doaj   +1 more source

Significance of PSA-density: analysis in PSA gray zone cases [PDF]

, 2001
1998～2000年に前立腺特異抗原(PSA)の高値(4以上)を指摘された為に精査目的で受診, もしくは排尿障害などを理由に受診した症例を対象とした.生検後の病理診断結果は116例で前立腺癌を認めず, 88例に前立腺癌を認めた.又, 生検を行った204例のうち81例がPSAが4以上10未満のgray zoneに属していた.生検での癌の検出率はPSA 4未満では11例中1例, 4以上10未満では81例中11例, 10以上20未満では49例中16例, 20以上30未満では20例中15例 ...
井川, 靖彦, 石塚, 修, 西沢, 理, 岩田, 研司   +3 more
core  

Adaptive Network Stabilization Despite Profound Structural Reorganization in Human Organotypic Cultures

Advanced Science, EarlyView.
Adult human organotypic cortical slices undergo marked neuronal loss, laminar disruption, and glial activation, yet their network activity progressively stabilizes after a variable period. Electrophysiology, longitudinal calcium imaging, and quantitative histology show that structurally remodeled human circuits show adaptive capacity resulting in ...
Estilla Zsófia Tóth, Rebeka Stelcz, Réka Bod, Ábel Petik, Eszter Juhász, Kinga Tóth, Liza Szalai, Nour Essam, Fanni Somogyi, Beatrix Kovács, Amirmahdi Mojtahedzadeh, Attila György Bagó, Loránd Erőss, Péter Orbay, Johanna Petra Szabó, Dániel Fabó, Boglárka Hajnal, Bence Rácz, Daniel Hillier, István Ulbert, Lucia Wittner   +20 more
wiley   +1 more source

Efficacy of Prostatic Specific Antigen as a Diagnostic Marker in Polycystic Ovary Syndrome and its Correlation with Lipid Profile [PDF]

Al-Anbar Medical Journal
Background: Polycystic ovary syndrome (PCOS) is a complex endocrine disorder affecting a significant proportion of women and can lead to amenorrhea and infertility.
Aseel Rifat
doaj   +1 more source

Calculation of PSA Density with transabdominal ultrasound, transrectal ultrasound and computed tomography and its correlation with the PSA Density of the radical prostatectomy specimen in prostate cancer patients

, 2016
Objective: The aim of the present study was to examine the accuracy of PSA density calculated with three different imaging modalities and compared to the PSA density of the radical prostatectomy specimen.Patients and methods: The PSA density of 60 men ...
Ζαρκαδούλιας, Αδάμ, Zarkadoulias, Adam   +1 more
core   +1 more source

Beyond Charge: Field‐Effect Transistors in Multimodal Biosensing Platforms for Biomolecular Interaction Studies

Advanced Electronic Materials, EarlyView.
This review summarizes the developments in field‐effect transistor (FET)‐based dual‐mode sensor platforms and what can be learned from them. It identifies charge as a crucial factor in biomolecular interactions at interfaces, outlines the challenges of hybrid systems, and highlights their benefits.
Roger Hasler, Ciril Reiner‐Rozman, Christoph Kleber, Jakub Dostalek, Wolfgang Knoll   +4 more
wiley   +1 more source

Correlation of Serum Gamma Glutamyl Transferase and Prostate Specific Antigen Level in Patients with Prostate Disorders

Pakistan Armed Forces Medical Journal
Objective: To correlate gamma-glutamyl transferase, prostate-specific antigen, and prostate-specific antigen density with ultrasound findings, including prostate-specific antigen volume and density, in patients with prostate disorders and to compare ...
Mehreen Aftab Khan, Ayesha Hafeez, Muhammad Younas, Syeda Binte Zahra Rizvi, Waqas Hanif, Syed Hurr   +5 more
doaj   +1 more source

PSA and Beyond: The Past, Present, and Future of Investigative Biomarkers for Prostate Cancer

The Scientific World Journal, 2010
The discovery of prostate-specific antigen (PSA) as a biomarker represented a major discovery in the early diagnosis and monitoring of prostate cancer.
Jeffrey Tosoian, Stacy Loeb
doaj   +1 more source