Results 31 to 40 of about 6,818 (208)

Late infantile and adult‐onset metachromatic leukodystrophy due to novel missense variants in the PSAP gene: Case report from India

JIMD Reports, 2023
Metachromatic leukodystrophy (MLD) due to Sap‐B deficiency is a rare autosomal recessive disorder caused due to biallelic variants in the PSAP gene. The PSAP gene encodes a precursor protein prosaposin, which is subsequently cleaved to form four active ...
Jayesh Sheth, Aadhira Nair, Riddhi Bhavsar, Heli Shah, Naresh Tayade, C. Ratna Prabha, Frenny Sheth, Harsh Sheth   +7 more
doaj   +1 more source

Deficiency of Glucocerebrosidase Activity beyond Gaucher Disease: PSAP and LIMP-2 Dysfunctions [PDF]

Glucocerebrosidase (GCase) is a lysosomal enzyme that catalyzes the breakdown of glucosylceramide in the presence of its activator saposin C (SapC). SapC arises from the proteolytical cleavage of prosaposin (encoded by PSAP gene), which gives rise to ...
Andrea Dardis, Jessica Biasizzo, Andrea Bordugo, Eleonora Pavan, Silvia Cattarossi, Paolo Peruzzo, Natascha Bergamin, Annalisa Sechi, Maurizio Scarpa, Fabiana Colucci, Scarpa, Maurizio, Pavan E., Biasizzo, J., Sechi A., Peruzzo P., Bergamin N., Bordugo, Andrea, Pavan, E., Colucci, Fabiana, Biasizzo J., Bordugo A., Colucci F., Cattarossi S., Cattarossi, S., Biasizzo, Jessica, Dardis, Andrea, Cattarossi, Silvia, Scarpa M., Bergamin, Natascha, Dardis A., Peruzzo, Paolo, Pavan, Eleonora, Sechi, Annalisa   +32 more
core   +2 more sources

Opposing roles of acid phosphatase 1 (ACP1) and ACP3 in prostate cancer progression

BJU International, EarlyView.
Objectives To evaluate the roles of intracellular acid phosphatase 1 (ACP1) and ACP3 expression as biomarkers of prostate cancer progression through a systematic review and meta‐analysis assessing associations with disease presence, tumour aggressiveness, and patient prognosis.
Alessandra V. de S. Faria, Carmen V. Ferreira‐Halder, Maikel P. Peppelenbosch, Gwenny M. Fuhler   +3 more
wiley   +1 more source

Prosaposin promotes the proliferation and tumorigenesis of glioma through toll-like receptor 4 (TLR4)-mediated NF-κB signaling pathwayResearch in context

EBioMedicine, 2018
Background: As a neurotrophic factor, prosaposin (PSAP) can exert neuroprotective and neurotrophic effects. It is involved in the occurrence and development of prostate and breast cancer.
Yang Jiang, Jinpeng Zhou, Peng Luo, Huiling Gao, Yanju Ma, Yin-Sheng Chen, Long Li, Dan Zou, Ye Zhang, Zhitao Jing   +9 more
doaj   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, Volume 16, Issue 10, Page 1911-1924, October 2026.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Lipids and Neurotransmitters Mass Spectrometry Imaging Data from Dopaminergic PSAP Deficient (cPSAP^DAT) and Serotonergic PSAP deficient (cPSAP^SERT) Mice Brain Tissue sections

, 2023
The files above are MALDI-MSI (Matrix Assisted Laser Desorption Ionization - Mass Spectrometry Imaging) experiments. The dataset contains both imzML, which is the common MSI open file type containing x, y positions in tissue as well as m/z and intensity,
Per E. Andren (1527964), Anna Nilsson (15367138), Ibrahim Kaya (16754610), Reza Shariatgorji (15451053)   +3 more
core   +1 more source

Characterization of lysosomal proteins Progranulin and Prosaposin and their interactions in Alzheimer’s disease and aged brains: increased levels correlate with neuropathology

Acta Neuropathologica Communications, 2019
Progranulin (PGRN) is a protein encoded by the GRN gene with multiple identified functions including as a neurotrophic factor, tumorigenic growth factor, anti-inflammatory cytokine and regulator of lysosomal function.
Anarmaa Mendsaikhan, Ikuo Tooyama, Jean-Pierre Bellier, Geidy E. Serrano, Lucia I. Sue, Lih-Fen Lue, Thomas G. Beach, Douglas G. Walker   +7 more
doaj   +1 more source

Single‐Cell Dissection of Therapy‐Induced Remodeling Uncovers a Fibroblast‐Driven Immunosuppressive Niche and Targetable Vulnerabilities in Lethal Prostate Cancer

Advanced Science, Volume 13, Issue 56, 9 October 2026.
Single‐cell longitudinal profiling reveals that androgen‐deprivation therapy induces a DPT+ fibroblast‐complement axis that suppresses macrophage inflammation and drives CD8+ T cell exhaustion in prostate cancer. Concurrently, resistant epithelial subpopulations persist and engage TSPAN1‐ and NRXN1‐mediated programs promoting CRPC and neuroendocrine ...
Yang Chen, Dandan Dong, Jinling Liao, Naikai Liao, Mengqi Liu, Qin Zhang, Siting Chen, Qi Liu, Ying Lu, Tianyu Li, Chunlin Zou, Qiong Song, Qiuyan Wang, Jian Liang, Qiji Xie, Chengyang Li, Mengyun Wang, Jiwen Cheng, Zengnan Mo, Gong‐Hong Wei   +19 more
wiley   +1 more source

Prosaposin down-modulation decreases metastatic prostate cancer cell adhesion, migration, and invasion

Molecular Cancer, 2010
Background Factors responsible for invasive and metastatic progression of prostate cancer (PCa) remain largely unknown. Previously, we reported cloning of prosaposin (PSAP) and its genomic amplification and/or overexpression in several androgen ...
Pullikuth Ashok, Garai Jone, Velasco-Gonzalez Cruz, Liu Tao, Liu Zhenzhen, Delorme Nathalie, Hu Siyi, Koochekpour Shahriar   +7 more
doaj   +1 more source

Targeting Microglial Transcriptional Reprogramming as a Therapy Strategy for Alzheimer's Disease

BioEssays, Volume 48, Issue 10, October 2026.
Recent human genetic studies highlight the critical role of microglial pathways in Alzheimer's disease, with risk loci enriched in microglia‐specific genes such as SPI1 and MEF2C. Dysregulation of these transcription factors contributes to disease pathogenesis.
Byungwook Kim, Selena S. Wang, Justin R. Kim, Jungsu Kim   +3 more
wiley   +1 more source