Results 1 to 10 of about 2,176 (106)

Prosaposin/Saposin Expression in the Developing Rat Olfactory and Vomeronasal Epithelia [PDF]

Journal of Developmental Biology
Prosaposin is a glycoprotein widely conserved in vertebrates, and it acts as a precursor for saposins that accelerate hydrolysis in lysosomes or acts as a neurotrophic factor without being processed into saposins.
Kai Kitamura, Kyoko Saito, Takeshi Homma, Aimi Fuyuki, Sawa Onouchi, Shouichiro Saito   +5 more
doaj   +2 more sources

AZP2006 in Parkinson's disease models: A promising new neuroprotective treatment involving lysosomal homeostasis and the Progranulin/Prosaposin complex. [PDF]

PLoS ONE
The pathohistological hallmarks of Parkinson's disease are aggregated alpha-synuclein and other aggregation-prone proteins (Lewy bodies). Recent studies show mechanistic as well as genetic connections between lysosomal dysfunction and Parkinson's disease
Noelle Callizot, Georgia Culley, Grace Flower, Laura Rouvière, Véronique De Conto, Alexandre Wojcinski, Catherine Botto, Cecilia Estrella, Alexandre Henriques, Philippe Verwaerde   +9 more
doaj   +2 more sources

A guide to selecting high-performing antibodies for Prosaposin (UniProt ID: P07602) for use in western blot and immunoprecipitation [version 1; peer review: 2 approved] [PDF]

F1000Research
Prosaposin functions as a regulator of lysosomal enzymatic activity and as a neuroprotective player when secreted. Here we have characterized nine Prosaposin commercial antibodies for western blot and immunoprecipitation using a standardized experimental
Sara González Bolívar Bolívar, Carl Laflamme, Riham Ayoubi, Vera Ruíz Moleón, Vincent Francis, Peter S. McPherson   +5 more
doaj   +2 more sources

Prosaposin PS18 reduces dopaminergic neurodegeneration in a 6-hydroxydopamine rat model of Parkinson’s disease [PDF]

Scientific Reports, 2023
Saposin and its precursor prosaposin are endogenous proteins with neurotrophic and anti-apoptotic properties. Prosaposin or its analog prosaposin-derived 18-mer peptide (PS18) reduced neuronal damage in hippocampus and apoptosis in stroke brain. Its role
Kuo-Jen Wu, Tsai-Wei Hung, Yu-Syuan Wang, Yun-Hsiang Chen, Eun-Kyung Bae, Seong-Jin Yu   +5 more
doaj   +2 more sources

ACE‐mediated Glycosylation Stabilizes PSAP To Promote GPR37‐dependent Macrophage‐Nucleus Pulposus Cells Crosstalk and TGFβ Signaling in Alleviating Intervertebral Disc Degeneration [PDF]

Advanced Science
Intervertebral disc degeneration (IDD) represents a complex pathological process involving impaired cellular homeostasis and extracellular matrix dysregulation.
Youfeng Guo, Feng Wang, Bijun Wang, Yu Zhou, Chao Wang, Tao Hu, Desheng Wu   +6 more
doaj   +2 more sources

Secretory full-length human prosaposin (PSAP) inhibits SARS-CoV-2 infection through facilitating the release of S1 subunit of spike protein [PDF]

mBio
The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has profoundly impacted global public health and the economy.
Chongyang Zhang, Peiwen Ding, Xia Xiao, Bei Wang, He Huang, Qiao Zhang, Lili Ren, Zichun Xiang, Zhuo Zhou, Xiaobo Lei, Jianwei Wang   +10 more
doaj   +2 more sources

Bioinformatic analysis of brucellosis and construction of a diagnostic model based on key genes [PDF]

Scientific Reports
This study aims to identify and validate key genes associated with brucellosis. Due to diagnostic challenges, we focused on a bioinformatics-driven approach to construct a robust diagnostic model, providing a theoretical basis for clinical diagnosis.
Xia Wang, Qing-Cao Fei, Le Zhang, Xiao-Rong Mao, Zi-min Ma, Li-Na Ma, Xiang-Chun Ding   +6 more
doaj   +2 more sources

Oligodendrocyte prosaposin restores subarachnoid haemorrhage-induced consciousness impairment [PDF]

Experimental and Molecular Medicine
Subarachnoid haemorrhage (SAH) is a life-threatening cerebrovascular event frequently accompanied by consciousness disturbances, yet the underlying mechanisms remain poorly defined.
Haiying Li, Xiang Li, Zhongmou Xu, Chang Cao, Jinxin Lu, Haojie Ding, Lei Bai, Jin Tao, Lu Peng, Jiping Tang, Gang Chen   +10 more
doaj   +2 more sources

Prosaposin: A Multifaceted Protein Orchestrating Biological Processes and Diseases [PDF]

Cells
Prosaposin (PSAP), a multifunctional protein, plays a central role in various biological processes and diseases. It is the precursor of lysosomal activating protein, which is important for lipid metabolism and glucose metabolism.
Xin Li, Liang Guo
doaj   +2 more sources

Exploring biomarkers for diagnosing and predicting organ dysfunction in patients with perioperative sepsis: a preliminary investigation [PDF]

Perioperative Medicine
Objective Early diagnosis and prediction of organ dysfunction are critical for intervening and improving the outcomes of septic patients. The study aimed to find novel diagnostic and predictive biomarkers of organ dysfunction for perioperative septic ...
Linghui Jiang, Shiyu Chen, Shichao Li, Jiaxing Wang, Wannan Chen, Yuncen Shi, Wanxia Xiong, Changhong Miao   +7 more
doaj   +2 more sources