Results 21 to 30 of about 2,195 (122)

Role of sphingolipids in the transport of prosaposin to the lysosomes

Journal of Lipid Research, 1999
Prosaposin is the precursor of four lysosomal saposins that promote the degradation of glycosphingolipids (GSLs) by acidic hydrolases. GSLs contain a hydrophobic ceramide moiety, which acts as a membrane anchor, and a hydrophilic oligosaccharide chain ...
Stephane Lefrancois, Lorraine Michaud, Michel Potier, Suleiman Igdoura, Carlos R. Morales   +4 more
doaj   +1 more source

Saposin C promotes survival and prevents apoptosis via PI3K/Akt-dependent pathway in prostate cancer cells

Molecular Cancer, 2004
Background In addition to androgens, growth factors are also implicated in the development and neoplastic growth of the prostate gland. Prosaposin is a potent neurotrophic molecule. Homozygous inactivation of prosaposin in mice has led to the development
Lee Tae-Jin, Sartor Oliver, Luftig Ronald B, Koochekpour Shahriar   +3 more
doaj   +1 more source

Saposins: structure, function, distribution, and molecular genetics.

Journal of Lipid Research, 1992
Saposins A, B, C, and D are small heat-stable glycoproteins derived from a common precursor protein, prosaposin. These mature saposins, as well as prosaposin, activate several lysosomal hydrolases involved in the metabolism of various sphingolipids.
Y Kishimoto, M Hiraiwa, JS O'Brien
doaj   +1 more source

Seminolipid and its precursor/degradative product, galactosylalkylacylglycerol, in the testis of saposin A- and prosaposin-deficient mice

Journal of Lipid Research, 2003
Sphingolipid activator proteins (saposins A, B, C, and D) are derived from a common precursor protein (prosaposin) and specifically activate in vivo degradation of glycolipids with short carbohydrate chains.
Keiko Tadano-Aritomi, Junko Matsuda, Hirokazu Fujimoto, Kunihiko Suzuki, Ineo Ishizuka   +4 more
doaj   +1 more source

Temporal gene expression profiling reveals CEBPD as a candidate regulator of brain disease in prosaposin deficient mice

BMC Neuroscience, 2008
Background Prosaposin encodes, in tandem, four small acidic activator proteins (saposins) with specificities for glycosphingolipid (GSL) hydrolases in lysosomes.
Ran Huimin, Zamzow Matt, Williams Michael T, Jia Li, Sun Ying, Quinn Brian, Aronow Bruce J, Vorhees Charles V, Witte David P, Grabowski Gregory A   +9 more
doaj   +1 more source

Prosaposin hyperglycosylation: a novel tumor immune escape mechanism and implications for cancer immunotherapy [PDF]

Signal Transduction and Targeted Therapy
Matthias Peipp, Diana Dudziak, Christian Kellner   +2 more
doaj   +2 more sources

Impaired prosaposin lysosomal trafficking in frontotemporal lobar degeneration due to progranulin mutations

Nature Communications, 2017
Mutations in the granulin gene are associated with frontotemporal lobe dementia (FTLD) and a lysosomal storage disease. The authors show that reduced progranulin levels leads to impaired neuronal uptake and lysosomal delivery of prosaposin, and that ...
Xiaolai Zhou, Lirong Sun, Oliver Bracko, Ji Whae Choi, Yan Jia, Alissa L. Nana, Owen Adam Brady, Jean C. Cruz Hernandez, Nozomi Nishimura, William W. Seeley, Fenghua Hu   +10 more
doaj   +1 more source

Castration causes an increase in lysosomal size and upregulation of cathepsin D expression in principal cells along with increased secretion of procathepsin D and prosaposin oligomers in adult rat epididymis.

PLoS ONE, 2021
In the epididymis, lysosomal proteins of the epithelial cells are normally targeted from the Golgi apparatus to lysosomes for degradation, although their secretion into the epididymal lumen has been documented and associated with sperm maturation.
Lorena Carvelli, Andrea Carolina Aguilera, Leila Zyla, Laura Lucía Pereyra, Carlos R Morales, Louis Hermo, Miguel A Sosa   +6 more
doaj   +1 more source

Gaucher disease mouse models: point mutations at the acid β-glucosidase locus combined with low-level prosaposin expression lead to disease variants

Journal of Lipid Research, 2005
Gaucher disease is a common lysosomal storage disease caused by a defect of acid β-glucosidase (GCase). The optimal in vitro hydrolase activity of GCase requires saposin C, an activator protein that derives from a precursor, prosaposin.
Ying Sun, Brian Quinn, David P. Witte, Gregory A. Grabowski   +3 more
doaj   +1 more source

Characterization of Drosophila Saposin-related mutants as a model for lysosomal sphingolipid storage diseases

Disease Models & Mechanisms, 2017
Sphingolipidoses are inherited diseases belonging to the class of lysosomal storage diseases (LSDs), which are characterized by the accumulation of indigestible material in the lysosome caused by specific defects in the lysosomal degradation machinery ...
Julia Sellin, Heike Schulze, Marie Paradis, Dominic Gosejacob, Cyrus Papan, Andrej Shevchenko, Olympia Ekaterina Psathaki, Achim Paululat, Melanie Thielisch, Konrad Sandhoff, Michael Hoch   +10 more
doaj   +1 more source