The Proteomic Profiling of Circulating Extracellular Vesicles of Western Diet and Chemical‐Induced Murine MASH Model [PDF]
Kaohsiung Journal of Medical SciencesMetabolic dysfunction‐associated steatotic liver disease (MASLD) is an increasingly prevalent chronic liver condition that can progress to severe complications such as metabolic dysfunction‐associated steatohepatitis (MASH).
Szu‐Jen Wang +9 more
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Role and regulatory mechanism of GPR37 in neurological diseases [PDF]
Frontiers in Cellular NeuroscienceG protein-coupled receptor 37 is an orphan Class A GPCR predominantly expressed in the central nervous system (CNS), implicated in diverse physiological and pathological processes.
Shuo Liu +7 more
doaj +2 more sources
Accumulation of prosaposin and progranulin around the subfornical organ induces polydipsia in SAP-D-deficient mice [PDF]
Biochemistry and Biophysics ReportsProsaposin (PSAP), a precursor of saposins, is essential for lysosomal hydrolysis of sphingolipids. It binds with progranulin (PGRN) and transports from the Golgi to lysosomes, where it is processed into saposins.
Harumi Hisaki +9 more
doaj +2 more sources
A Hypertrophic Stimulus Drives Age-Dependent Transcript Isoform Switching With and Without Differential Gene Expression in Skeletal Muscle. [PDF]
Aging CellA combined analysis of short‐read and long‐read RNA‐seq demonstrates reduced isoform switching after an acute hypertrophic stimulus in aged muscle and identifies age‐dependent isoforms that may not be detected with total gene‐level analyses. ABSTRACT Aged skeletal muscle has a reduced ability to adapt to hypertrophic stimuli concomitant with ...
Koopmans PJ +5 more
europepmc +2 more sources
Prosaposin Is Cleaved Into Saposins by Multiple Cathepsins in a Progranulin-Regulated Fashion. [PDF]
J NeurochemProsaposin (PSAP) is a lysosomal protein cleaved into four bioactive saposins (SapA‐D) that regulate sphingolipid breakdown. Here, we identify nine cathepsins, including seven newly implicated enzymes, that process PSAP in a pH‐dependent manner to generate distinct cleavage products.
Hodul M +7 more
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Biomedicines, 2022 Malignant pleural mesothelioma is an aggressive malignancy with poor prognosis. Unilateral pleural effusion is frequently the initial clinical sign requiring therapeutic thoracentesis, which also offers a diagnostic opportunity.
Lorenzo Zallocco +8 more
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Temporal changes in prosaposin expression in the rat dentate gyrus after birth. [PDF]
PLoS ONE, 2014 Neurogenesis in the hippocampal dentate gyrus occurs constitutively throughout postnatal life. Adult neurogenesis includes a multistep process that ends with the formation of a postmitotic and functionally integrated new neuron. During adult neurogenesis,
Midori Morishita +7 more
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Prosaposin in seminal plasma on the day of oocyte retrieval is associated with normal fertilization and embryo development in in vitro fertilization cycles [PDF]
PeerJ, 2019 The prospective study including 166 participants aims to evaluate the association between seminal prosaposin and the outcomes of in vitro fertilization (IVF) cycles in humans.
Chun Xu +3 more
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JIMD Reports, 2023 Metachromatic leukodystrophy (MLD) due to Sap‐B deficiency is a rare autosomal recessive disorder caused due to biallelic variants in the PSAP gene. The PSAP gene encodes a precursor protein prosaposin, which is subsequently cleaved to form four active ...
Jayesh Sheth +7 more
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Cell Reports, 2023 Summary: Macrophages release soluble mediators following efferocytic clearance of apoptotic cells to facilitate intercellular communication and promote the resolution of inflammation. However, whether inflammation resolution is modulated by extracellular
Purbasha Bhattacharya +8 more
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